Cinnarizine is a Medicine belongs to Antihistamine (H1 blocker) group whose information about Brand can be referenced from   Book : Martindale    Page : 622   Edition : 38, Martindale    Page : 622   Edition : 38,    Page :   Edition : ,

  ►   Brandname : Avidazine,Cintigo,Diziron,Stugeron,Vertiron,Bo Rui Te,Vertizac

  ►  Strength : Tablet with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 622   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 622   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Vertigo Oral 30 mg t.i.d.
2 Vestibular disorders Oral 30 mg t.i.d.
3 Motion sickness Oral 30 mg 2 hours before the start of the journey.
4 Motion sickness Oral 15 mg t.i.d. During the journey if necessary.
5 Cerebrovascular disorders Oral 75 mg o.d.
6 Peripheral vascular disease Oral 75 mg b.d/t.i.d

Ref :-  Book : Martindale    Page : 623   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Vestibular disorders 5 Year 12 Year Oral 15 mg t.i.d.
2 Motion sickness Oral 15 mg

Ref :- Book : Martindale    Page : 623   Edition : 38,
►  Side Effect : CNS depression, slight drowsiness to deep sleep, lassitude, Dizziness, incoordination, extrapyramidal symptoms, depressive feelings, headache, psychomotor impairment, thickened respiratory-tract secretions, Blurred Vision, urinary difficulty, urinary retention, constipation, diarrhoea, epigastric pain, hypersensitivity reactions, bronchospasm, blood disorder, agranulocytosis, leucopenia, convulsion, sweating, myalgia, tremor, Sleep disturbances, Confusion, hypotension, hair loss,
Ref :-   Book : Martindale    Page : 622,613   Edition : 38, Martindale    Page : 611, 623   Edition : 37,

►  Drug Interaction : Drug interaction of Cinnarizine is with Barbiturates , Hypnotic , opioid analgesics, Anxiolytic sedatives, Antipsychotic , Alcohol, Tricyclic antidepressant , Monoamine Oxidase Inhibitor,  Atropine ,
Ref :-   Book : Martindale    Page : 622,614   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Cinnarizine may enhance the sedative effects of CNS depressants including alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives, and antipsychotics. Sedative interactions apply to a lesser extent with the non-sedating antihistamines; they do not appear to potentiate the effects of alcohol, but it should be avoided in excess. Sedating antihistamines have an additive antimuscarinic action with other antimuscarinic drugs, such as atropine and some antidepressants (both tricyclics and MAOIs). ,
Ref :-   Book : Martindale    Page : 622,614   Edition : 38,


►  Contraindication : hepatic impairment, Cardiac disease, Hypokalaemia, electrolyte imbalance, prolonged QT interval, hypertension,
Ref :-   Book : Martindale    Page : 622,613   Edition : 38, Martindale    Page : 622   Edition : 38,
  ►  Mechanism of Action :   Cinnarizine is a piperazine derivative with antihistamine, sedative, and calcium-channel blocking activity.,
Ref :-   Book : Martindale    Page : 622   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Onion with Another pathway,

  ►  Pathway with its reference as follows :-
  • Onion having active constituent quercetin which act as antihistamine effect . --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 622   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   3 hours,    Max value :-   6 hours,
    Ref :-   Book : Martindale    Page : 622   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 622   Edition : 38,