Ciprofloxacin is a Medicine belongs to Antibacterial/ Fluoroquinolones group whose information about Brand can be referenced from   Book : Martindale    Page : 265,266   Edition : 38,    Page :   Edition : ,

  ►   Brandname : Ciproxin,C-Lox; Cipr-saar; Ciprobay; Abact; Adcip; Bicipro; C-Flox; C-Pro; Biocip; Cbic; Celox; Cip; Flocin,Ciloxan,Cetraxal,Cipran,Ciplox-TZ,Cifran

  ►  Strength : Tablet with 100  mg, Tablet with 250  mg, Tablet with 500  mg, Tablet with 750  mg, Tablet (Extended Release Tablets) with 500  mg, Tablet (Extended Release Tablets) with 1000  mg, Suspension with 50  mg/ml, Suspension with 100  mg/ml, Injection with 10  mg/ml, Ophthalmic Solution with 3  mg/ml, Ointment with 3.3  mg/gm, Eye Drop with   , Ear Drop with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 837   Edition : 12, Martindale    Page : 261   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, Topical,
Reference :-   Book : Basic & Clinical pharmacology    Page : 837   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Chronic bacterial prostatitis Oral 500 mg Tablet b.d.
2 Chronic bacterial prostatitis IV 400 mg Injection b.d.
3 Anthrax IV 400 mg Injection b.d.
4 Anthrax Oral 500 mg Tablet b.d.
5 Cutaneous anthrax Oral 500 750 mg Tablet b.d.
6 Gonorrhoea Oral 500 mg Tablet Single dose.
7 Surgical infection prophylaxis Oral 750 mg Tablet Single dose.
8 Meningococcal infections Oral 500 mg Tablet Single dose.

Ref :-  Book : Martindale    Page : 261   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Serious infections 1Year More than 1Year Oral 20 mg/kg Tablet b.d.
2 Serious infections 1 Year More than 1 Year IV 10 mg/kg Injection t.i.d.
3 Serious infections Oral 15 mg/kg Tablet b.d.
4 Serious infections IV 10 mg/kg Injection b.d.
5 Serious infections 1 Month 18 Year Oral 20 mg/kg Tablet b.d.
6 Serious infections 1 Month 18 Year Oral 10 mg/kg Tablet t.i.d.
7 Anthrax IV 10 mg/kg Injection b.d.
8 Anthrax Oral 15 mg/kg Tablet b.d.
9 Cystic fibrosis 1 Year More than 1 Year Oral 20 mg/kg Tablet b.d.
10 Cystic fibrosis 1 Year More than 1 Year IV 10 mg/kg Injection t.i.d.
11 Urinary-tract infections 1 Year More than 1 Year Oral 10 20 mg/kg Tablet b.d.
12 Urinary-tract infections 1 Year More than 1 Year IV 6 10 mg/kg Injection t.i.d.
13 Urinary-tract infections Oral 10 mg/kg Tablet b.d.
14 Urinary-tract infections IV 6 mg/kg Injection b.d.
15 Urinary-tract infections 1 Month 18 Year Oral 10 20 mg/kg Tablet b.d.
16 Urinary-tract infections 1 Month 18 Year IV 6 10 mg/kg Injection t.i.d.
17 Pyelonephritis 1 Year More than 1 Year Oral 10 20 mg/kg Tablet b.d.
18 Pyelonephritis 1 Year More than 1 Year IV 6 10 mg/kg Injection t.i.d.
19 Pyelonephritis Oral 10 mg/kg Tablet b.d.
20 Pyelonephritis IV 6 mg/kg Injection b.d.
21 Pyelonephritis 1 Month 18 Year Oral 10 20 mg/kg Tablet b.d.
22 Pyelonephritis 1 Month 18 Year IV 6 10 mg/kg Injection t.i.d.
23 Meningococcal meningitis 1 Month 5 Year Oral 125 mg Tablet
24 Meningococcal meningitis 5 Year 12 Year Oral 250 mg Tablet
25 Meningococcal meningitis More than 12 Year Oral 500 mg Tablet
26 Gonorrhoea More than 12 Year Oral 500 mg Tablet

Ref :- Book : Martindale    Page : 262   Edition : 38,
Precaution :- If a Patient is using 'Ciprofloxacin' drug in  Generalized, Tonic-Clonic Seizures  disease, then Please Not to be given .

Precaution :- If a Patient is using 'Ciprofloxacin' drug in  MYASTHENIA GRAVIS  disease, then Please Use with caution .

Precaution :- If a Patient is using 'Ciprofloxacin' drug in  thallasemia  disease, then Please Avoid .

Precaution :- If a Patient is using 'Ciprofloxacin' drug in acute kidney injury disease, then Please use with caution   if he ever suffered from urinary tract infection disease.
►  Side Effect : Rashes, pruritus, arthralgia, photosensitivity, anaphylaxis, diarrhea, Dizziness, headache, Confusion, reversible arthropathy, corneal precipitates, Gastrointestinal upset, nausea, vomiting, abdominal pain, dyspepsia, Pseudomembranous colitis, Pancreatitis, dysphagia, convulsion, Depression, intracranial hypertension, Paresthesia of the extremities, peripheral neuropathies, vasculitis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, myalgia, muscle weakness, Crystalluria, Acute renal failure, Elevated liver enzyme values, jaundice, hepatitis, Pain, Irritation, phlebitis, thrombophlebitis, local burning, keratopathy, corneal staining, photophobia,
Ref :-   Book : Clinical Pharmacology    Page : 193   Edition : 9, Martindale    Page : 262   Edition : 38,

►  Drug Interaction : Drug interaction of Ciprofloxacin is with Histamine H2-receptor antagonist, , , ,  Theophylline , Tizanidine , Clozapine , Glibenclamide , Phenytoin , Probenecid , Iron , Warfarin , Methotrexate, Cyclosporine ,
Ref :-   Book : Martindale    Page : 264   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Ciprofloxacin, inhibit the cytochrome P450 isoenzyme CYP1A2 and may increase plasma concentrations of drugs, such as theophylline and tizanidine, that are metabolised by this isoenzyme. Use of ciprofloxacin with tizanidine is contra-indicated, although theophylline may be used providing its dose is reduced and concentrations monitored. Ciprofloxacin is reported to enhance the effect of oral anticoagulants such as warfarin and the oral antidiabetic glibenclamide. Severe hypoglycaemia, sometimes fatal, has occurred in patients also taking glibenclamide. Renal tubular secretion of methotrexate may be inhibited by ciprofloxacin, potentially increasing its toxicity. The excretion of ciprofloxacin or related drugs is reduced and plasma concentrations may be increased by probenecid. Cations such as aluminium, calcium, magnesium, or iron reduce the absorption of oral ciprofloxacin or related drugs when given together. Changes in the pharmacokinetics of fluoroquinolones have been reported when given with histamine H2 antagonists, possibly due to changes in gastric pH, but do not seem to be of much clinical significance. Transient increases in serum creatinine have occurred when ciprofloxacin is given with ciclosporin; monitoring of serum creatinine concentrations is recommended. Altered serum concentrations of phenytoin have been reported in patients also receiving ciprofloxacin. ,
Ref :-   Book : Martindale    Page : 264   Edition : 38,


►  Contraindication : Epilepsy, History of CNS disorder, renal impairment, G6PD deficiency, Risk of crystalluria, Tendon pain, Inflammation, History of myasthenia gravis, Sunlight, Sunlamps, electrolyte imbalance, Bradycardia , Cardiac disease, MRSA infection,
Ref :-   Book : Martindale    Page : 264   Edition : 38,
  ►  Mechanism of Action :   The quinolone antibiotics target bacterial DNA gyrase and topoisomerase IV. For many gram-positive bacteria (such as S. aureus), topoisomerase IV is the primary activity inhibited by the quinolones.,
Ref :-   Book : Goodman    Page : 1470   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Eyebright with Another pathwayAnother pathway, Eyebright with Another pathwayAnother pathway, Red algae with Another pathway,

  ►  Pathway with its reference as follows :-
  • Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan --- ( Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press )
  • Lobelin It acts as a strong and protective barrier over the affected mucous membranes of the eyes and enables a quick recovery --- ( kokate, D. & Purohit, A. (2013). pharmacognosy. Abhyudaya pragati: Nirali prakashan. )
  • Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan --- ( Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press )
  • Lobelin It acts as a strong and protective barrier over the affected mucous membranes of the eyes and enables a quick recovery --- ( kokate, D. & Purohit, A. (2013). pharmacognosy. Abhyudaya pragati: Nirali prakashan. )
  • Antibiotic effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf, https://www.sapnaonline.com/books/pharmacognosy-ck-kokate-8196396155-9788196396152, http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- MAGNESIUM with Dietary Substance is Drug Inhibitor, CALCIUM with Dietary Substance is Drug Inhibitor, VITAMIN K with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Renal, Biliary, Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 265   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   3 hours,    Max value :-   5 hours,
    Ref :-   Book : Martindale    Page : 265   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 265   Edition : 38,