Cisapride is a Medicine belongs to Gastrointestinal drug/ Prokinetic group whose information about Brand can be referenced from   Book : Martindale    Page : 1832   Edition : 38,

  ►   Brandname : Alipride,Cisalone,Gastro

  ►  Strength :

A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1832   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Gastro-oesophageal reflux disease Oral 5 10 mg t.i.d/q.i.d

Ref :-  Book : Martindale    Page : 1832   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Oral 200 micrograms/kg t.i.d/q.i.d

Ref :- Book : Martindale    Page : 1832   Edition : 38,
►  Side Effect : gastrointestinal disturbance, abdominal cramp, borborygmi, diarrhea, headache, lightheadedness, torsade de pointes, disturbances of liver function, hypersensitivity reactions, pruritus, bronchospasm, convulsion, extrapyramidal disorders, urinary frequency,
Ref :-   Book : Martindale    Page : 1832   Edition : 38,

►  Drug Interaction : Drug interaction of Cisapride is with selective serotonin reuptake inhibitors,  Atazanavir, Clarithromycin , Cyclosporine , Erythromycin , Nefazodone, Ritonavir, Selegiline ,
Ref :-   Book : Basic & Clinical pharmacology    Page : 1156   Edition : 12,


  ►    Mechanism of Drug Drug Interaction :  Atazanavir: [NE] Decreased metabolism of cisapride; possible ventricular arrhythmia. Clarithromycin: [NP] Decreased metabolism of cisapride; possible ventricular arrhythmia. Cyclosporine: [NE] Decreased metabolism of cisapride; possible ventricular arrhythmia. Erythromycin: [NP] Decreased metabolism of cisapride; possible ventricular arrhythmia. Nefazodone: [NP] Possibly decreased metabolism of cisapride by CYP3A4; possible ventricular arrhythmia. Ritonavir: [NE] Decreased metabolism of cisapride; possible ventricular arrhythmia. Selective serotonin reuptake inhibitors (SSRIs): [NP] Fluvoxamine inhibits CYP3A4 and probably decreases cisapride metabolism; possible ventricular arrhythmia.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 1156   Edition : 12,


►  Contraindication : Gastrointestinal haemorrhage, obstruction, perforation, Immediately after surgery, Clinically significant heart disease, electrolyte imbalance, renal failure, respiratory failure, hepatic impairment, renal impairment, those taking other drugs that predispose to electrolyte disturbances or that prolong the QT interval, those with a personal or family history of QT interval prolongation, those with a history of ventricular arrhythmia or torsade de pointes, Arrhythmia, premature infants for up to 3 months after birth., those receiving potent inhibitors of the cytochrome P450 isoenzyme CYP3A4 such as macrolide antibacterials, azole antifungals, HIV-protease inhibitors, or nefazodone,
Ref :-   Book : Martindale    Page : 1832   Edition : 38,
  ►  Mechanism of Action :   Cisapride is a substituted benzamide used for its prokinetic properties. It stimulates gastrointestinal motility, probably by increasing the release of acetylcholine in the gut wall at the level of the myenteric plexus, increases the resting tone of the lower oesophageal sphincter, and increases the amplitude of lower oesophageal contractions. Gastric emptying is accelerated and the mouth-to-caecum transit time is reduced. Colonic peristalsis is also increased which decreases colonic transit time,
Ref :-   Book : Martindale    Page : 1832   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Peppermint oil with Another pathway,

  ►  Pathway with its reference as follows :-
  • Peppermint oil having active constituent menthol which is effective in the treatment of gastroesophageal reflux disease . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1832   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   10 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1832   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 1832   Edition : 38,