Cisplatin is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 768   Edition : 38,

  ►   Brandname : Cisplat,Cytoplatin,Kemoplat,Platinex,Platinol

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 769   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 766   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Testicular cancer IV infusion 20 mg/m2 Injection daily for 5 days every 3 to 4 weeks.
2 Monotherapy IV infusion 50 120 mg/m2 Injection Single dose every 3 to 4 weeks.
3 Combination chemotherapy IV infusion 20 mg/m2 Injection Given once every 3 to 4 weeks.

Ref :-  Book : Martindale    Page : 766   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : nephrotoxicity, ototoxicity, hypersenstivity, nausea, vomiting, electrolyte disturbances, hypomagnesaemia, hypocalcaemia, hyperuricaemia, bone marrow depression, loss of hearing, Deafness, peripheral neuropathies, loss of taste, seizure, optic neuritis, papilloedema, papilloedema, Cerebral blindness, Anaphylactoid reactions, injection-site reactions,
Ref :-   Book : Martindale    Page : 767   Edition : 38,

►  Drug Interaction : Drug interaction of Cisplatin is with Myelosuppressive drugs, Nephrotoxic drugs, Ototoxic Drugs,  NA

  ►    Mechanism of Drug Drug Interaction :  Use with other myelosuppressive, nephrotoxic or ototoxic drugs may exacerbate the adverse effects of cisplatin. ,
Ref :-   Book : Martindale    Page : 768   Edition : 38,


►  Contraindication : bone marrow depression, hearing impairment, renal impairment,
Ref :-   Book : Martindale    Page : 764   Edition : 37,
  ►  Mechanism of Action :   Forms intrastrand and interstand DNA cross links binding to nuclear and cytoplasmic protein,
Ref :-   Book : Basic & Clinical pharmacology    Page : 956   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- with Another pathway, Ginseng i.e Ashwagandha with same compound,

  ►  Pathway with its reference as follows :-
  • Ginseng inhibits growth of cancer by interfering with the DNA synthesis --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Ginsenosides, Panaxosides have anticancer effect --- (Chen, Yan et al. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html, https://cancerci.biomedcentral.com/articles/10.1186/1475-2867-13-24,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- CALCIUM with Decrease in Nutrient Level, MAGNESIUM with Decrease in Nutrient Level, VITAMIN E with Dietary Substance is Drug Enhancer, SODIUM with Decrease in Nutrient Level, SODIUM with Decrease in Nutrient Level, ZINC with Dietary Substance is Drug Enhancer,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- GLUTAMINE with It reduced chemotherapy induced mouth sore ., GLUTATHIONE with High - dose cisplatin therapy is associated with kidney toxicity and damage , which may be reduced by glutathione administration ., N-ACETYLCYSTEINE with It decrease the kidney and bladder toxicity of the chemotherapy drug ., SELENIUM with It reduced the kidney damage and white blood cell- lowering effects of cisplatin ., MILK THRISTYL with Having flavonoids silymarin , have shown synergistic actions with the chemotherapy drug cisplatin .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 766   Edition : 38,


    ►    Plasma Half-life :   Min value :-   25 minutes,    Max value :-   49 minutes,
    Ref :-   Book : Martindale    Page : 768   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA