Citalopram is a Medicine belongs to Antidepressant group whose information about Brand can be referenced from   Book : Martindale    Page : 412   Edition : 38  

  ►   Brandname : Celexa, Cipramil, Citadep, Citopam; C-Pam; C-Talo
  ►  Strength : Tablet with 10 mg.  Tablet with 20 mg.  Tablet with 40 mg.  Solution with 10/5 mg/ml. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 539   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 411   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Depression Oral 20 mg Tablet Daily, After at least one week the dose may be increased to 40 mg daily.
2 Obsessive-compulsive disorder Oral 20 mg Tablet Daily, After at least one week the dose may be increased to 40 mg daily.,
3 Panic disorder with or without agoraphobia Oral 10 mg Tablet Daily increasing to 20 mg daily after one week.

Ref :-  Book : Martindale    Page : 411   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Premenstrual dysphoric disorder 10- 20 (Starting Dose) 20-30 (Therapeuitic Dose) mg
2 Depression 10 40 mg
3 Depression 40 mg
4 Anxiety 10 40 mg
5 Anxiety 40 mg

Ref :- Book : Nelson's textbook of Pediatrics    Page : 692   Edition : 19   Nelson's textbook of Pediatrics    Page : 63   Edition : 19  
►  Side Effect : Increased appetite, Weight gain, Prolong QT interval , Prolongation of torsade de points
Ref :-   Book : Martindale    Page : 411   Edition : 38.  

►  Drug Interaction : Drug interaction of Citalopram is with Theophylline
Ref :-   Book : Martindale    Page : 411,426   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  Citalopram can greatly increase plasma concentrations of theophylline.
Ref :-   Book : Martindale    Page : 411,426   Edition : 38.  


►  Contraindication : Arrhythmia including those with congenital QT prolongation, Congestive heart failure, Bradycardia , Predisposition to hypokalaemia, Hypomagnesaemia
Ref :-   Book : Martindale    Page : 411   Edition : 38.  
  ►  Mechanism of Action :   Citalopram, a phthalane derivative, is an Selective serotonin reuptake inhibitor. Prevention of the reuptake of monoamine transmitters such as serotonin, which potentiates their action in the brain, appears to be associated with antidepressant activity
Ref :-   Book : Martindale    Page : 411,417   Edition : 38.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Belladonna with Another pathway.   Belladonna with Another pathway.   Poppy seed with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Increasing anticholinergic activity of tricyclic antidepressants . --- ( Duke, J. (2002). Handbook of Medicinal Herbs (2nd ed.). Boca Raton London New York Washington ,D.C. )
  • Increasing anticholinergic activity of tricyclic antidepressants . --- ( Duke, J. (2002). Handbook of Medicinal Herbs (2nd ed.). Boca Raton London New York Washington ,D.C. )
  • Act as antidepressant . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL --
  • http://www.crcnetbase.com/doi/pdf/10.1201/9781420040463.fmatt .
  • http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- BELLABONNA with .   BELLABONNA with .   LITHIUM with Dietary Substance is Drug Enhancer.  

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL --
    http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf


    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- BELLADONNA with Increasing anticholinergic activity of tricyclic antidepressants ..   GINKGO BILOBA with Ginkgo Biloba extract may reduce .  

      ►  Reference :-
  • Duke, J. (2002). Handbook of Medicinal Herbs (2nd ed.). Boca Raton London New York Washington ,D.C.
  • Duke, J. (2002). Handbook of Medicinal Herbs (2nd ed.). Boca Raton London New York Washington ,D.C.
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.crcnetbase.com/doi/pdf/10.1201/9781420040463.fmatt
    http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf

    ►   Route of Elimination :   Renal
    Ref :-   Book : Martindale    Page : 411   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   36 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 411   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   4 hours.  
    Ref :-   Book : Martindale    Page : 411   Edition : 38.