Clarithromycin is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 268   Edition : 38  

  ►   Brandname : Acem; Acgel; Acnesol-CL; Bioclar; Synclar; Clarosip; Biaxin; Clarithrobeta
  ►  Strength : Tablet with 250 mg.  Tablet with 500 mg.  Tablet (Extended Release Tablets) with 500 mg.  Tablet (Extended Release Tablets) with 1000 mg.  Suspension with 125/5 mg/ml.  Suspension with 250/5 mg/ml.  Injection with

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 819   Edition : 12   Martindale    Page : 268   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV infusion
Reference :-   Book : Martindale    Page : 266   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Severe infections Oral 250 mg Tablet b.d. Increased to 500 mg twice daily if necessary.
2 Leprosy Oral 500 mg Tablet Daily.
3 Peptic ulcer disease Oral 500 mg Tablet b.d. Is given with another antibacterial and either a proton pump inhibitor or a histamine H2- receptor antagonist, for 7 to 14 days.
4 Severe infections IV 500 mg Injection b.d. Given as an infusion over 60 minutes using a solution containing about 0.2% of clarithromycin.
5 Prophylaxis of disseminated infection Oral 500 mg Tablet b.d. For treatment, it should be given with other antimycobacterials.

Ref :-  Book : Martindale    Page : 266   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Antibacterial Oral 7.5 mg/kg Tablet b.d.
2 Severe infections 1 Month 12 Year IV 7.5 mg/kg Injection b.d.
3 Severe infections IV 500 mg Injection b.d.
4 Prophylaxis of disseminated infection Oral 7.5 mg/kg Tablet b.d.
5 For the eradication of Helicobacter pylori associated with peptic ulcer 1 Year over 1 Year Oral 7.5 mg/kg Tablet b.d.
6 Prevention of secondary cases of Pertussis Oral 7.5 mg/kg Tablet b.d.
7 Prevention of secondary cases of Pertussis 1 Month 12 Year under 8 kg Oral 7.5 mg/kg Tablet b.d.
8 Prevention of secondary cases of Pertussis 1 Month 12 Year 8 to 11 kg Oral 62.5 mg Tablet b.d.
9 Prevention of secondary cases of Pertussis 1 Month 12 Year 12 to 19 kg Oral 125 mg Tablet b.d.
10 Prevention of secondary cases of Pertussis 1 Month 12 Year 20 to 29 kg Oral 187.5 mg Tablet b.d.
11 Prevention of secondary cases of Pertussis 1 Month 12 Year 30 to 40 kg Oral 250 mg Tablet b.d.
12 Prevention of secondary cases of Pertussis from 12 Year Oral 500 mg Tablet b.d.

Ref :- Book : Martindale    Page : 266   Edition : 38  
►  Side Effect : Gastrointestinal disturbance, Taste disturbances, Stomatitis, Glossitis, Headache, Arthralgia, Myalgia, Hypoglycemia, leucopenia, Thrombocytopenia, Muscle weakness, Phlebitis, Smell disturbances, Tongue discoloration, Tooth discoloration, Transient CNS effects, Pain at the injection site
Ref :-   Book : Martindale    Page : 267   Edition : 38.  

►  Drug Interaction : Drug interaction of Clarithromycin is with Hmg-Coa Reductase Inhibitors,  Carbamazapine , Cisapride , Colchicine , Cyclosporine , Digitalis, Pimozide , Quinidine , Theophylline
Ref :-   Book : Basic & Clinical pharmacology    Page : 1155   Edition : 12.   Basic & Clinical pharmacology    Page : 1156   Edition : 12.   Basic & Clinical pharmacology    Page : 1157   Edition : 12.   Basic & Clinical pharmacology    Page : 1159   Edition : 12.  


  ►    Mechanism of Drug Drug Interaction :  The macrolides clarithromycin inhibit CYP3A4 and P-glycoprotein, clarithromycin Increased pimozide concentrations, clarithromycin Increased serum quinidine concentrations, clarithromycin Decreased metabolism of theophylline, Clarithromycin, Decreased metabolism of calcium channel blockers, clarithromycin Decreased carbamazepine metabolism, Clarithromycin Decreased metabolism of cisapride; possible ventricular arrhythmia, Clarithromycin Decreased colchicine metabolism and transport, Clarithromycin Decreased cyclosporine metabolism, Clarithromycin Increased plasma concentration of digoxin, Clarithromycin Decreased statin metabolism.
Ref :-   Book : Basic & Clinical pharmacology    Page : 1154-1159   Edition : 12.  


►  Contraindication : Renal impairment, Hepatic impairment, Pregnancy
Ref :-   Book : Martindale    Page : 267   Edition : 38.  
  ►  Mechanism of Action :   It is a bacteriostatic agent that inhibit protein synthesis by binding reversibly to 50S ribosomal subunits of sensitive microorganisms.
Ref :-   Book : Goodman    Page : 1530   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Red algae with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Cycloeudesmol have Antibiotic effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL --
  • http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- VITAMIN K with Decrease in Nutrient Level.  

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf


    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- PROBIOTICS with It prevent antibiotic-induced diarrhea ..  

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf

    ►   Route of Elimination :   Fecal, Hepatic (Metabolism), Renal, Biliary
    Ref :-   Book : Martindale    Page : 268   Edition : 38.   Martindale    Page : 68   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   3 hours,    Max value :-   4 hours.  
    Ref :-   Book : Martindale    Page : 268   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   3 hours.  
    Ref :-   Book : Martindale    Page : 268   Edition : 38.