Clindamycin is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 272   Edition : 38,

  ►   Brandname : Climycin,Clincin,Dalacin C,Cleocin; Basocin

  ►  Strength : Capsule with 75  mg, Capsule with 150  mg, Capsule with 300  mg, Oral solution with 75/5  mg/ml, Injection with 150  mg/ml, Gel with   , Topical solution with   , Topical Suspension with   , Vaginal cream with   , Ovules with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 819   Edition : 12, Martindale    Page : 273   Edition : 38, Harrison's principles of internal medicine    Page : 1102   Edition : 18,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, Topical, IM,
Reference :-   Book : Martindale    Page : 270   Edition : 38, Nelson's textbook of Pediatrics    Page : 645   Edition : 19,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Bacterial vaginosis Intravaginally 2 % Cream Each night for 7 nights.
2 Bacterial vaginosis Oral 300 mg b.d. Daily for 7 days.
3 Malaria Oral 10 mg Capsule b.d. For 7 days.
4 Endocarditis Oral 600 mg Capsule Patient with Penicillin allergy; 1 h before procedure.
5 Endocarditis IM or IV 600 mg Injection In patient with Penicillin allergy, inability to take oral medication. 1 h before procedure.
6 Necrotizing fasciitis (group A streptococcalb) IV 600 900 mg Intravenous infusion t.i.d/q.i.d Plus Penicillin G, 4 million units IV q4h. For Primary Treatment
7 Necrotizing fasciitis (group A streptococcalb) IV 600 900 mg Injection t.i.d/q.i.d Plus Cephalosporin (first- or second-generation), For Alternative Treatment.
8 Animal bites IV 600 900 mg Injection t.i.d. With Ciprofloxacin.
9 Cellulitis IV 600 900 mg Injection t.i.d.
10 Gas gangrene IV 600 900 mg Injection t.i.d/q.i.d Plus Penicillin G, 4 million units IV q4–6h. Primary Treatment.
11 Gas gangrene IV 600 900 mg Injection t.i.d/q.i.d Plus Cefoxitin, 2 g IV q6h. For Alternative Treatment
12 Clostridial Infection IV 600 900 mg Injection t.i.d/q.i.d Plus Ciprofloxacin (400 mg IV q6–8 h). Condition: Polymicrobial anaerobic infections involving clostridia (e.g., abdominal wall, gynecologic).
13 Clostridial Infection IV 600 900 mg Injection t.i.d/q.i.d Plus Penicillin, 3–4 mU IV q4–6h. Condition: Clostridial sepsis
14 Bacterial vaginosis Oral 300 mg b.d. Daily for 7 days.
15 Skin and soft-tissue infections Oral 300 450 mg/kg t.i.d. Patient Resistant to methicillin.
16 Babesiosis 600 mg t.i.d. plus Quinine (650 mg tid).
17 Pneumocystosis IV 600 mg Injection t.i.d/q.i.d Plus primaquine, 15–30 mg qd PO.
18 Sepsis with Soft Tissue Findings 600 mg t.i.d. plus Gentamicin (5 mg/kg per day). .
19 Pneumocystosis Oral 300 450 mg q.i.d. Plus primaquine, 15–30 mg qd PO.
20 Actinomycosis IV 900 mg Injection t.i.d.
21 Actinomycosis Oral 300 450 mg Capsule q.i.d.
22 Necrotizing fasciitis (mixed aerobes and anaerobes) IV 600 900 mg Injection t.i.d/q.i.d Plus Ciprofloxacin, 400 mg IV q6–8h. For Primary Treatment.
23 Gas gangrene IV 600 900 mg Injection t.i.d/q.i.d Plus Cefoxitin, 2 g IV q6h. For Alternative Treatment
24 Human Babesiosis IV 300 600 mg Injection q.i.d. Plus Quinine (650 mg q6–8h PO). Plus Consider RBC exchange transfusion. If caused by B. microti.
25 Human Babesiosis Oral 600 mg t.i.d. Plus Quinine (650 mg q6–8h PO). Plus Consider RBC exchange transfusion. If caused by B. microti.
26 Human Babesiosis IV 7 10 mg/kg Injection t.i.d/q.i.d Maximum, 600 mg/dose) Plus Quinine (8 mg/kg q8h PO; maximum, 650 mg/dose). If caused by B. divergens.
27 Human Babesiosis IV 7 10 mg/kg Injection t.i.d/q.i.d Maximum, 600 mg/dose) Plus Quinine (8 mg/kg q8h PO; maximum, 650 mg/dose). If caused by B. divergens.
28 Babesial Infections IV 600 mg Injection t.i.d/q.i.d Plus oral quinine (600–650 mg tid) for 7–10 days.
29 Babesial Infections IV 1200 mg Injection b.d. Plus oral quinine (600–650 mg tid) for 7–10 days.
30 Bacterial vaginosis Intravaginally 100 gm Ovules Once at bedtime for 3 days.
31 Pelvic Inflammatory Disease IV 900 mg Injection t.i.d. Plus Gentamicin (loading dose of 2 mg/kg IV or IM, then maintenance dose of 1.5 mg/kg q8h).
32 Acute sinusitis Oral 300 mg q.i.d. Plus Amoxicillin, 1500 mg bid.
33 Acute Otitis Media Oral 30 40 mg/kg q.i.d. In divided doses (tid). Mild to moderate Condition.
34 Acute Otitis Media Oral 30 40 mg/kg q.i.d. In divided doses (tid). In Severe condition.

Ref :-  Book : Harrison's principles of internal medicine    Page : 1102   Edition : 18, Harrison's principles of internal medicine    Page : 1699   Edition : 18, Harrison's principles of internal medicine    Page : 1063   Edition : 18, Martindale    Page : 1063   Edition : 18, Harrison's principles of internal medicine    Page : 1070   Edition : 18, Harrison's principles of internal medicine    Page : 1205   Edition : 18, Harrison's principles of internal medicine    Page : 1169   Edition : 18, Martindale    Page : 1026   Edition : 18, Harrison's principles of internal medicine    Page : 1673   Edition : 18, Harrison's principles of internal medicine    Page : 1025   Edition : 18, Harrison's principles of internal medicine    Page : 1330   Edition : 18, Harrison's principles of internal medicine    Page : 1707   Edition : 18, Harrison's principles of internal medicine    Page : 1708   Edition : 18, Harrison's principles of internal medicine    Page : 1106   Edition : 18, Harrison's principles of internal medicine    Page : 258   Edition : 18, Harrison's principles of internal medicine    Page : 261   Edition : 18,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Pelvic Inflammatory Disease IV 900 mg Injection t.i.d.
2 Antibiotic Therapy 0 Week 4 Week Less than 1200 gm PO, IM, IV 5 mg/kg b.d.
3 Streptococcal pharyngitis Oral 20 mg/kg/day Capsule
4 Cystic fibrosis lung infection Oral 10 30 mg/kg/day Capsules
5 Uncomplicated falciparum malaria Oral 20 mg/kg/day Capsules
6 Severe malaria IV 10 mg/kg Injection
7 Antibiotic Therapy IV 40 mg/kg/day Injection
8 Antibiotic Therapy IV 30 40 mg/kg/day Injection t.i.d.
9 Antibiotic Therapy 0 Day 7 Day 1200-2000 gm PO, IM, IV 5 mg/kg b.d.
10 Antibiotic Therapy more than 7 Day 1200-2000 gm PO, IM, IV 5 mg/kg t.i.d.
11 Antibiotic Therapy 0 Day 7 Day more than 2000 gm PO, IM, IV 5 mg/kg t.i.d.
12 Antibiotic more than 7 Day more than 2000 gm PO, IM, IV 5 mg/kg q.i.d.

Ref :- Book : Nelson's textbook of Pediatrics    Page : 939   Edition : 19, Nelson's textbook of Pediatrics    Page : 645   Edition : 19, Nelson's textbook of Pediatrics    Page : 1440   Edition : 19, Nelson's textbook of Pediatrics    Page : 1492   Edition : 19, Nelson's textbook of Pediatrics    Page : 1203   Edition : 19, Nelson's textbook of Pediatrics    Page : 1205   Edition : 19, Nelson's textbook of Pediatrics    Page : 2397   Edition : 19,
►  Side Effect : diarrhea, nausea, Skin rashes, neutropenia, colitis, Impaired liver function (with or without jaundice),
Ref :-   Book : Basic & Clinical pharmacology    Page : 815   Edition : 12, Martindale    Page : 815   Edition : 12,

►  Drug Interaction : Drug interaction of Clindamycin is with Macrolide, Parasympathomimetic, STREPTOGRAMINS ,  ketolides, Linezolid , Chloramphenicol ,
Ref :-   Book : Martindale    Page : 272   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Clindamycin may antagonise the effects of parasympathomimetics. Clindamycin may competitively inhibit the effects of macrolides, ketolides, streptogramins, linezolid, and chloramphenicol because they all bind to the same subunit of the ribosome.,
Ref :-   Book : Martindale    Page : 272   Edition : 38,


►  Contraindication : Hypersensitive to Clindamycin or closely related drug lincomycin, gastrointestinal disease, diarrhoea, colitis, Atopic patients , parenteral use in neonates,
Ref :-   Book : Martindale    Page : 271   Edition : 38,
  ►  Mechanism of Action :   Clindamycin, like erythromycin, inhibits protein synthesis by interfering with the formation of initiation complexes and with aminoacyl translocation reactions. The binding site for clindamycin on the 50S subunit of the bacterial ribosome is identical with that for erythromycin. ,
Ref :-   Book : Basic & Clinical pharmacology    Page : 815   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Red algae with Another pathway,

  ►  Pathway with its reference as follows :-
  • Cycloeudesmol Aerropysinl have Antibiotic effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- VITAMIN A with Increase in Nutrient Level, IRON with Dietary Substance is Drug Inhibitor, VITAMIN K with Decrease in Nutrient Level,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- PROBIOTICS with It helps prevent antibiotic induced diarrhea .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,

    ►   Route of Elimination :   Fecal, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 272   Edition : 38,


    ►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   3 hours,
    Ref :-   Book : Martindale    Page : 272   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 272   Edition : 38,