Clofazimine is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 274   Edition : 38,

  ►   Brandname : Clofozine,Hansepran,Lamprene

  ►  Strength : Capsule with 50  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 848   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 848   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Multibacillary leprosy Oral Capsule Rifampicin 600 mg and clofazimine 300 mg are both given once a month, together with daily doses of clofazimine 50 mg and dapsone 100 mg; this treatment continues for 12 months.
2 Chronic Type 2 lepra reactions Oral Up to 300 mg Capsule Daily but it should not be given for longer than 3 months.

Ref :-  Book : Martindale    Page : 273   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Red to brown discoloration of the skin, Discoloration of hair, tears, sweat, Discoloration of sputum, breast milk, urine, and faeces, diarrhea, weight loss, gastrointestinal bleeding, Bowel obstruction, dryness of the skin, ichthyosis, Rashes, pruritus, acneform eruption, photosensitivity reactions, decreased sweat production, Decreased tear production, eyes irritation,
Ref :-   Book : Martindale    Page : 273, 274   Edition : 38, Martindale    Page : 274   Edition : 38,

►  Drug Interaction : Drug interaction of Clofazimine is with Isoniazid , Dapsone ,
Ref :-   Book : Martindale    Page : 274   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Elevated plasma and urine concentrations of clofazimine have been detected in patients receiving high doses of clofazimine with isoniazid, although skin concentrations were found to be lower. Anti-inflammatory effects may be inhibited by dapsone,
Ref :-   Book : Martindale    Page : 274   Edition : 38,


►  Contraindication : Gastrointestinal symptoms such as abdominal pain and diarrhoea., Daily doses of more than 100 mg should not be used for more than 3 months, Reddish-brown discoloration of breast milk, hair, skin, conjunctiva, tears, sputum, sweat, urine, and faeces.,
Ref :-   Book : Martindale    Page : 274   Edition : 38,
  ►  Mechanism of Action :   The biochemical basis for the antimicrobial action of clofazimine remain to be establish. Possible mechanism of action include: • Membrane disruption • Inhibition of mycobacterial phospholipase A2 • Inhibition of microbial K+ transport • Generation of H peroxide • Interference with the bacterial electron transport chain. It has both antibacterial activity as well as anti-inflammatory effects via inhibition of macrophages, T cells, neutrophils, and complement. ,
Ref :-   Book : Goodman    Page : 1559   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- chaulmoogea oil with Another pathway,

  ►  Pathway with its reference as follows :-
  • Anti leprotic effect . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary, Fecal, Renal, Sebaceous gland, sputum, Sweat,
    Ref :-   Book : Martindale    Page : 277   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   10 Days,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 274   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   5.3 hours,    Max value :-   7.8 hours,
    Ref :-   Book : Goodman    Page : 1560   Edition : 12,