Clomiphene citrate is a Medicine belongs to Sex harmones and their modulators group whose information about Brand can be referenced from   Book : Martindale    Page : 2260   Edition : 38  

  ►   Brandname : Clofert, Clopreg, Clomid, Serophene
  ►  Strength : Tablet with 50 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 740   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 2259   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Infertility Oral 50 mg Tablet Daily for 5 days, starting on or about the 5th day of the menstrual cycle or at any time if there is amenorrhoea.

Ref :-  Book : Martindale    Page : 2259   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1

Ref :- Book :    Page :    Edition :   
►  Side Effect : Reversible ovarian enlargement and cyst formation, Vasomotor flushes resembling menopausal symptoms, Abdominal or pelvic discomfort or pain, sometimes with nausea or vomiting., Ovarian hyperstimulation, Breast tenderness, Abnormal uterine bleeding, Weight gain, Headache, Endometriosis, Visual disturbances, Blurred Vision, Cataract, Optic neuritis, Skin reactions, Allergic rashes, Urticaria, , CNS disturbances, Convulsion, Dizziness, Lightheadedness, Nervous tension, Fatigue, Vertigo, Insomnia, Depression, Abnormalities in liver function, Jaundice, Increased risk of multiple births , Increased risk of ectopic pregnancy
Ref :-   Book : Martindale    Page : 2259   Edition : 38.  

►  Drug Interaction : Drug interaction of Clomiphene citrate is with NA

  ►    Mechanism of Drug Drug Interaction :  N.F.R.B
Ref :-   Book :    Page :    Edition : .  


►  Contraindication : Liver disease, Liver dysfunction, Pregnancy, Uterine bleeding, Women with ovarian cysts, except those with polycystic ovary syndrome,, Uterine fibroids
Ref :-   Book : Martindale    Page : 2259   Edition : 38.  
  ►  Mechanism of Action :   Estrogen antagonist in some tissues and estrogen agonist in other tissues. The basis for tissue selectivity may be related to tissue-specific expression of estrogen receptor subtypes and the differential ability of the ligand-receptor complex to recruit transcriptional coactivators and corepressors.
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 521   Edition : 3.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Shatavari with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Estrogen receptor modulator --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL --
  • http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Biliary, Faecal, Hepatic (Metabolism)
    Ref :-   Book : Basic & Clinical pharmacology    Page : 733   Edition : 12.   Martindale    Page : 2259   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   5 days,    Max value :-   7 days.  
    Ref :-   Book : Basic & Clinical pharmacology    Page : 733   Edition : 12.  

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA