Clomipramine is a Medicine belongs to Antidepressant group whose information about Brand can be referenced from   Book : Martindale    Page : 413   Edition : 38,

  ►   Brandname : Anafranil; Clofranil; Clom; Clomine;

  ►  Strength : Capsule with 25  mg, Capsule with 50  mg, Capsule with 75  mg, Tablet with   , Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 539   Edition : 12, Martindale    Page : 413   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM, IV,
Reference :-   Book : Martindale    Page : 412   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Obsessive-compulsive disorder Oral 25 mg Tablet/Capsule Daily (or 10 mg daily for elderly patients or those sensitive to tricyclics) increased gradually over two weeks to 100 to 150 mg daily.
2 Obsessive-compulsive disorder IM 25 50 mg Injection Daily, increasing to a maximum of 100 to 150 mg daily;
3 Obsessive-compulsive disorder IV infusion 50 75 mg Injection Daily diluted in 250 to 500 mL of sodium chloride 0.9% or glucose 5% and infused over 1.5 to 3 hours.
4 Depression Oral 10 mg Tablet/Capsule Daily initially, increasing gradually to 30 to 150 mg daily if required; up to 250 mg daily or higher may be given in severe cases.
5 Cataplexy associated with narcolepsy. Oral 10 mg Tablet/Capsule Daily and gradually increased until a satisfactory response occurs, usually within the range of 10 to 75 mg daily.

Ref :-  Book : Martindale    Page : 412   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Obsessive-compulsive disorder 10 Year More than 10 Year Oral 25 mg Tablet/Capsule

Ref :- Book : Martindale    Page : 412   Edition : 38,
►  Side Effect : weight gain, dry mouth, urinary retention, Blurred Vision, increased intraocular pressure, Sedation, sexual dysfunction, hypothermia, drowsiness, insomnia, headache, peripheral neuropathy, tremor, ataxia, epileptiform seizures, tinnitus, extrapyramidal symptoms, Confusion, hallucinations, delirium, sour taste, metallic taste, stomatitis, gastric irritation, nausea, vomiting, hypersensitivity reactions, testicular enlargement, Gynaecomastia, breast enlargement, galactorrhoea, Increased appetite, Speech Difficulties, Urticaria, photosensitisation,
Ref :-   Book : Martindale    Page : 412,401   Edition : 38,

►  Drug Interaction : Drug interaction of Clomipramine is with Barbiturates , Antiepileptics , Antipsychotic , Calcium Channel Blockers , ,  Cimetidine , Methylphenidate , Rifampicin ,
Ref :-   Book : Martindale    Page : 412, 406   Edition : 38, Martindale    Page : 412,406   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Drugs that inhibit or induce the cytochrome P450 isoenzyme CYP2D6 may affect tricyclic metabolism and produce marked alterations in plasma concentrations. Barbiturates and other enzyme inducers such as rifampicin and some antiepileptics can increase the metabolism of tricyclic antidepressants and may lower plasma concentrations and reduce antidepressant response. Cimetidine, methylphenidate, antipsychotics, and calcium channel blockers can reduce the metabolism of the tricyclics, leading to the possibility of increased plasma concentrations and accompanying toxicity.,
Ref :-   Book : Martindale    Page : 412,406   Edition : 38,


►  Contraindication : Untreated angle-closure glaucoma, phaeochromocytoma, cardiovascular disease, heart block , Cardiac arrhythmias, myocardial infarction , hyperthyroidism, hepatic impairment, severe liver disease,
Ref :-   Book : Martindale    Page : 412,404   Edition : 38,
  ►  Mechanism of Action :   Clomipramine inhibit the neuronal reuptake of noradrenaline in the CNS; some, in addition, inhibit the reuptake of serotonin (5-HT). Prevention of the reuptake of these monoamine neurotransmitters, which potentiates their action in the brain, appears to be associated with antidepressant activity.,
Ref :-   Book : Martindale    Page : 401   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Ashwagandha with Another pathway,

  ►  Pathway with its reference as follows :-
  • antidepressant effect . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 413   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   21 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 413   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA