Clonazepam is a Medicine belongs to Antiseizure drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 520   Edition : 38      Page :   Edition :   

  ►   Brandname : Epitril, epizam, Klonopin; Clon; Rivotril, Petril Beta, Petril Plus, Clonafit, Clonafit MD, Clonafit Plus, Cloze MD
  ►  Strength : Tablet with 0.5 mg.  Tablet with 1 mg.  Tablet with 2 mg.  Oral Suspension with .  Injection with

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 427   Edition : 12   Martindale    Page : 520   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV infusion
Reference :-   Book : Martindale    Page : 519   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Panic disorder Oral 250 micrograms Tablet b.d.
2 Status epilepticus IV injection or infusion 1 mg Injection Given by slow intravenous injection over at least 2 minutes or by intravenous infusion, repeated if necessary to a maximum total dose of 20 mg.
3 Epilepsy Oral 1 mg (500 micrograms in the elderly) Tablet h.s. At night for 4 nights gradually increased over 2 to 4 weeks to a usual maintenance dose of 4 to 8 mg daily.
4 Myoclonus Oral 1mg (500 micrograms in the elderly) Tablet h.s. At night for 4 nights gradually increased over 2 to 4 weeks to a usual maintenance dose of 4 to 8 mg daily.

Ref :-  Book : Martindale    Page : 519   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Epilepsy Oral up to 250 micrograms Tablet
2 Epilepsy Oral 0.5 1 mg Tablet
3 Epilepsy 1 Year 5 Year Oral 1 3 mg Tablet
4 Epilepsy 5 Year 12 Year Oral 3 6 mg Tablet
5 Epilepsy Oral up to 500 micrograms Tablet
6 Myoclonus Oral Up to 250 micrograms Tablet
7 Myoclonus Oral 500 micrograms Tablet

Ref :- Book : Martindale    Page : 519   Edition : 38  
►  Side Effect : Drowsiness, Thrombophlebitis, Hypotension, Sedation, Muscle weakness, Ataxia, Vertigo, Headache, Confusion, Depression, Slurred speech, Changes in libido, Tremor, Visual disturbances, Urinary incontinence, Urinary retention, Amnesia
Ref :-   Book : Martindale    Page : 520, 1065   Edition : 38.  

►  Drug Interaction : Drug interaction of Clonazepam is with Alcohol, Antidepressant , sedating antihistamine , Antipsychotic , General anaesthetics , Sedatives- hypnotics , opioid analgesics,  NA

  ►    Mechanism of Drug Drug Interaction :  Enhanced sedation or respiratory and cardiovascular depression may occur if Clonazepam given with other drugs that have CNS depressant properties; these include alcohol, antidepressants, sedative antihistamines, antipsychotics, general anaesthetics, other hypnotics or sedatives, and opioid analgesics.
Ref :-   Book : Martindale    Page : 520,1068   Edition : 38.  


►  Contraindication : CNS depression, Coma, Respiratory depression, Acute pulmonary insufficiency, Myasthenia gravis, Acute apnea, Severe hepatic impairment
Ref :-   Book : Martindale    Page : 520,1066   Edition : 38.  
  ►  Mechanism of Action :   Potentiates GABA A responses
Ref :-   Book : Basic & Clinical pharmacology    Page : 425   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Ginkgo biloba with same pathway.  

  ►  Pathway with its reference as follows :-
  • binding GABA receptors . --- (Johnston, G. & Chebib, ,. (2009). Herbal Products and GABA Receptors. Encyclopedia Of Neuroscience, 4, 1095-1101. )

  •   ►  URL --
  • https://pdfs.semanticscholar.org/29c9/cd318614fd90fc9dda0ece219069af3d7dfc.pdf .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- FOLIC ACID with Reduces blood levels of folic acid dramatically increases homocysteine levels ..   VITAMIN E with Lower blood vitamin E levels ..   VITAMIN D with Long -term anti-convulsant treatment appears to interfere with vitamin D activity , which might lead to softening of bones . .   VITAMIN D with Long -term anticonvulsant treatment decrease blood levels of biotin ..   VITAMIN A with Long-term lowered blood level of vitamin A ..  

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf


    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal
    Ref :-   Book : Martindale    Page : 520   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   20 hours,    Max value :-   40 hours.  
    Ref :-   Book : Martindale    Page : 520   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   4 hours.  
    Ref :-   Book : Martindale    Page : 520   Edition : 38.