Clonazepam is a Medicine belongs to Antiseizure drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 520   Edition : 38,    Page :   Edition : ,

  ►   Brandname : Epitril,epizam,Klonopin; Clon; Rivotril,Petril Beta,Petril Plus,Clonafit,Clonafit MD,Clonafit Plus,Cloze MD

  ►  Strength : Tablet with 0.5  mg, Tablet with 1  mg, Tablet with 2  mg, Oral Suspension with   , Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 427   Edition : 12, Martindale    Page : 520   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV infusion,
Reference :-   Book : Martindale    Page : 519   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Panic disorder Oral 250 micrograms Tablet b.d.
2 Status epilepticus IV injection or infusion 1 mg Injection Given by slow intravenous injection over at least 2 minutes or by intravenous infusion, repeated if necessary to a maximum total dose of 20 mg.
3 Epilepsy Oral 1 mg (500 micrograms in the elderly) Tablet h.s. At night for 4 nights gradually increased over 2 to 4 weeks to a usual maintenance dose of 4 to 8 mg daily.
4 Myoclonus Oral 1mg (500 micrograms in the elderly) Tablet h.s. At night for 4 nights gradually increased over 2 to 4 weeks to a usual maintenance dose of 4 to 8 mg daily.

Ref :-  Book : Martindale    Page : 519   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Epilepsy Oral up to 250 micrograms Tablet
2 Epilepsy Oral 0.5 1 mg Tablet
3 Epilepsy 1 Year 5 Year Oral 1 3 mg Tablet
4 Epilepsy 5 Year 12 Year Oral 3 6 mg Tablet
5 Epilepsy Oral up to 500 micrograms Tablet
6 Myoclonus Oral Up to 250 micrograms Tablet
7 Myoclonus Oral 500 micrograms Tablet

Ref :- Book : Martindale    Page : 519   Edition : 38,
►  Side Effect : drowsiness, thrombophlebitis, hypotension, Sedation, muscle weakness, ataxia, vertigo, headache, Confusion, Depression, slurred speech, changes in libido, tremor, visual disturbances, urinary incontinence, urinary retention, amnesia, ,
Ref :-   Book : Martindale    Page : 520, 1065   Edition : 38,

►  Drug Interaction : Drug interaction of Clonazepam is with Alcohol, Antidepressant , sedating antihistamine , Antipsychotic , General anaesthetics , Sedatives- hypnotics , opioid analgesics,  NA

  ►    Mechanism of Drug Drug Interaction :  Enhanced sedation or respiratory and cardiovascular depression may occur if Clonazepam given with other drugs that have CNS depressant properties; these include alcohol, antidepressants, sedative antihistamines, antipsychotics, general anaesthetics, other hypnotics or sedatives, and opioid analgesics. ,
Ref :-   Book : Martindale    Page : 520,1068   Edition : 38,


►  Contraindication : CNS depression, coma, respiratory depression, acute pulmonary insufficiency, Myasthenia gravis, acute apnea, Severe hepatic impairment,
Ref :-   Book : Martindale    Page : 520,1066   Edition : 38,
  ►  Mechanism of Action :   Potentiates GABA A responses,
Ref :-   Book : Basic & Clinical pharmacology    Page : 425   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Ginkgo biloba with same pathway,

  ►  Pathway with its reference as follows :-
  • binding GABA receptors . --- (Johnston, G. & Chebib, ,. (2009). Herbal Products and GABA Receptors. Encyclopedia Of Neuroscience, 4, 1095-1101. )

  •   ►  URL -- https://pdfs.semanticscholar.org/29c9/cd318614fd90fc9dda0ece219069af3d7dfc.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- FOLIC ACID with Reduces blood levels of folic acid dramatically increases homocysteine levels ., VITAMIN E with Lower blood vitamin E levels ., VITAMIN D with Long -term anti-convulsant treatment appears to interfere with vitamin D activity , which might lead to softening of bones . , VITAMIN D with Long -term anticonvulsant treatment decrease blood levels of biotin ., VITAMIN A with Long-term lowered blood level of vitamin A .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- with Puerarin reduce the effect of clonazepam,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 520   Edition : 38,


    ►    Plasma Half-life :   Min value :-   20 hours,    Max value :-   40 hours,
    Ref :-   Book : Martindale    Page : 520   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 520   Edition : 38,