Clonidine is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1376   Edition : 37, Martindale    Page : 1342   Edition : 38,

  ►   Brandname : Arkamin,Catapres,Dixarit,Duraclon,cloneon

  ►  Strength : Tablet with 0.1  mg, Tablet with 0.2  mg, Tablet with 0.3  mg, Transdermal Patch with 0.1  mg/day, Transdermal Patch with 0.2  mg/day, Transdermal Patch with 0.3  mg/day,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 189   Edition : 12, Clinical Pharmacology    Page : 189   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, Transdermal,
Reference :-   Book : Martindale    Page : 1339   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 hypertension Oral 50 100 micrograms Tablet t.i.d.
2 hypertension Oral 100 micrograms Tablet b.d.
3 hypertension Transdermal 100 300 micrograms Transdermal Patch Daily at a constant rate.
4 hypertension IV 750 micrograms Injection Dose: over 24 hours.
5 Severe hypertension Oral 100 200 micrograms Tablet
6 Migraine Oral 50 micrograms Tablet b.d. It is also used for Recurrent vascular Headaches, menopausal flushing.
7 Cancer pain epidural infusion 30 micrograms/hour
8 Hypertensive crises IV 150 300 micrograms Injection over 10 to 15 min

Ref :-  Book : Martindale    Page : 1339   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Severe hypertension 2 Year more than 2 Year Oral 1.5 3 micrograms/kg Tablet
2 Severe hypertension IV 2 6 micrograms/kg Injection

Ref :- Book : Martindale    Page : 1339   Edition : 38,
Precaution :- If a Patient is using 'Clonidine' drug in  hypertension  disease, then Please be used with caution .

►  Side Effect : drowsiness, dry mouth, Dizziness, headache, constipation, Depression, anxiety, fatigue, nausea, anorexia, parotid pain, Sleep disturbances, vivid dreams, impotence, loss of libido, urinary retention, incontinence, Orthostatic hypotension, fluid retention, pruritus, bradycardia, Sinus bradycardia, heart failure, hallucinations, Raynaud’s syndrome, Gynaecomastia, dry sensations in the eye, itching sensations in the eye, burning sensations in the eye, transient rashes, ECG abnormalities, cramp,
Ref :-   Book : Martindale    Page : 1372   Edition : 37,

►  Drug Interaction : Drug interaction of Clonidine is with Diuretic Agents , Antihypertensive Agents , Tricyclic antidepressant , CNS depressant,  NA

  ►    Mechanism of Drug Drug Interaction :  The hypotensive effect of clonidine may be enhanced by diuretics, other antihypertensives, and drugs that cause hypotension and tricyclic antidepressants may antagonise the hypotensive effect. The sedative effect of clonidine may be enhanced by CNS depressants,
Ref :-   Book : Martindale    Page : 1342   Edition : 38,


►  Contraindication : Cerebrovascular disease, ischaemic heart disease, myocardial infarction , renal impairment, Raynaud’s disease,
Ref :-   Book : Martindale    Page : 1341   Edition : 38,
  ►  Mechanism of Action :   Clonidine is an imidazoline antihypertensive that appears to act centrally to reduce sympathetic tone, resulting in a fall in diastolic and systolic blood pressure and a reduction in heart rate. The exact mechanism is unclear; clonidine stimulates alpha2 adrenoceptors and central imidazoline receptors, but it is not known which receptors mediate which effects. It also acts peripherally, and this peripheral activity may be responsible for the transient increase in blood pressure,
Ref :-   Book : Martindale    Page : 1339   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Thuja with Another pathway,

  ►  Pathway with its reference as follows :-
  • Anti nococeptive property --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 1374   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   6 hours,    Max value :-   24 hours,
    Ref :-   Book : Martindale    Page : 1342   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   3 hours,    Max value :-   5 hours,
    Ref :-   Book : Martindale    Page : 1342   Edition : 38,