Clozapine is a Medicine belongs to Antipsychotic group whose information about Brand can be referenced from   Book : Martindale    Page : 1062   Edition : 38,

  ►   Brandname : Clozaril,FazaClo; Elcrit; Chrozap; Versacloz,Lozapin

  ►  Strength : Tablet with 12.5  mg, Tablet with 25  mg, Tablet with 50  mg, Tablet with 100  mg, Tablet with 200  mg, Oral Suspension with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 519   Edition : 12, Martindale    Page : 1062   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1062   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Schizophrenia Oral 12.5 mg Tablet o.d/b.d Followed by 25 mg once or twice on the second day.
2 Psychoses in Parkinson’s disease Oral 12.5 mg Tablet o.d. In the evening.

Ref :-  Book : Martindale    Page : 1057   Edition : 38, Martindale    Page : 1057   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
Precaution :- If a Patient is using 'Clozapine' drug in  Generalized, Tonic-Clonic Seizures  disease, then Please Not to be given .

►  Side Effect : Sedation, weight gain, Reversible neutropenia, fatal agranulocytosis, eosinophilia, agranulocytosis, , tachycardia, Orthostatic hypotension, Dizziness, hypersalivation, headache, nausea, vomiting, constipation, urinary incontinence, urinary retention, fatigue, transient fever, ,
Ref :-   Book : Martindale    Page : 1058   Edition : 38,

►  Drug Interaction : Drug interaction of Clozapine is with Alcohol, antihistamines, Benzodiazepine , opioid analgesics, Antineoplastic , , , Long-acting depot antipsychotics, , alpha-adrenoceptor agonists, Monoamine Oxidase Inhibitor, CNS depressant,  Carbamazapine , Chloramphenicol , Penicillamine , Sulfonamide, Azapropazone, Noradrenaline/Norepinephrine , Phenytoin ,
Ref :-   Book : Martindale    Page : 1061   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Clozapine may enhance the central effects of MAOIs and CNS depressants including alcohol, antihistamines, benzodiazepines, and opioid analgesics. Clozapine should not be used with drugs that carry a high risk of bone-marrow suppression including carbamazepine, co-trimoxazole, chloramphenicol, penicillamine, sulfonamides, antineoplastics, or pyrazolone analgesics such as azapropazone. Long-acting depot antipsychotics have myelosuppressive potential and should not be used with clozapine as they cannot be withdrawn rapidly should neutropenia occur. Additive effects may occur when clozapine is given with drugs that possess antimuscarinic, hypotensive, or respiratory depressant effects. Clozapine may reduce the effects of alpha-adrenoceptor agonists such as noradrenaline. The metabolism of clozapine is mediated mainly by the cytochrome P450 isoenzyme CYP1A2. Use with drugs that inhibit or act as a substrate to this isoenzyme may affect plasma concentrations of clozapine. Use with phenytoin or other enzyme-inducing drugs may accelerate the metabolism of clozapine and reduce its plasma concentrations. ,
Ref :-   Book : Martindale    Page : 1061   Edition : 38,


►  Contraindication : Used with caution in patients with a history of seizures or with conditions that lower the seizure threshold, in benign prostatic hyperplasia and angle-closure glaucoma, in mild to moderate renal impairment and in hepatic impairment., It is contra-indicated in patients with bone-marrow suppression, myeloproliferative disorders, or any abnormalities of white blood cell count or differential blood count, in patients with a history of drug-induced neutropenia or agranulocytosis with the exception of that due to chemotherapy, in patients with severe renal impairment;, It should not be used with drugs that carry a high risk of bone-marrow suppression, in severe heart failure. Avoided in symptomatic or progressive liver disease or hepatic failure. It is contra-indicated in patients with paralytic ileus.,
Ref :-   Book : Martindale    Page : 1060   Edition : 38,
  ►  Mechanism of Action :   Clozapine is a dibenzodiazepine derivative and the prototype of the atypical antipsychotics. It has relatively weak dopamine receptor-blocking activity at D1, D2, D3, and D5 receptors but has a high affinity for the D4 receptor. Clozapine possesses alpha-adrenergic blocking, antimuscarinic, antihistaminic, antiserotonergic, and sedative properties.,
Ref :-   Book : Martindale    Page : 1057   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Yage with Another pathway,

  ►  Pathway with its reference as follows :-
  • Harmaline have antipsycotic effect --- (18. PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- GLYCINE with Dietary Substance is Drug Inhibitor, N-ACETYLCYSTEINE with Dietary Substance is Drug Inhibitor, VITAMIN C with Dietary Substance is Drug Enhancer, SELENIUM with Decrease in Nutrient Level, TRYPTOPHAN with Decrease in Nutrient Level, CAFFEINE with Dietary Substance is Drug Enhancer,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf, https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 1062   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   12 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1062   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   2.5 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1062   Edition : 38,