Coagulation factor VIII(Anti haemophilic Factor-A) is a Medicine belongs to Blood Products Plasma Expanders and Haemostatics group whose information about Brand can be referenced from   Book : Martindale    Page : 1149   Edition : 38,

  ►   Brandname : Advate,Alphanate,Helixate,Hemofil M,Humate-P,Kogenate,Monarc-M,Monoclate-P,Recombinate,ReFacto,Xyntha; Emoclot; Fanhdi

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1148   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV injection or infusion,
Reference :-   Book : Martindale    Page : 1148   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Mild to moderate haemorrhage IV 10 15 units/kg Injection Single dose.
2 Serious haemorrhage IV 15 25 units/kg Injection Followed by 10 to 15 units/kg every 8 to 12 hours if required.
3 Severe haemorrhage IV 40 50 units/kg Injection Followed by 20 to 25 units/kg every 8 to 12 hours.
4 Prophylaxis in severe haemophilia A IV 10 50 units/kg Injection Every 2 or 3 days.

Ref :-  Book : Martindale    Page : 1148   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 HEMOPHILIA A IV Injection
2 HEMOPHILIA A
3 HEMOPHILIA A
4 HEMOPHILIA A
5 HEMOPHILIA A
6 HEMOPHILIA A
7 HEMOPHILIA A

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1701   Edition : 19,
►  Side Effect : chills, Urticaria, headache, hyperfibrinogenaemia, hepatitis,
Ref :-   Book : Martindale    Page : 1176   Edition : 37,

►  Drug Interaction : Drug interaction of Coagulation factor VIII(Anti haemophilic Factor-A) is with NA

  ►    Mechanism of Drug Drug Interaction :  NA


►  Contraindication : NA
  ►  Mechanism of Action :   NA

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Spinach with Another pathway,

  ►  Pathway with its reference as follows :-
  • Spinach having vitamin K which help in coagulation of blood . --- (Gopalan, C. (2012). Nutritive value of Indian foods. National Institute of Nutrition ,ICMR.: Hyderabad 500007,INDIA. )

  •   ►  URL -- https://books.google.co.in/books?id=biFBAAAAYAAJ&q=Gopalan, +C., +Rama+Sastri, +B., +%26+Balasubramanian, +S.+(1971).+Nutritive+value+of+Indian+foods.+Hyderabad, +India:+National+Institute+of+Nutrition, +Indian+Council+of+Medical+R,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :
      Min value :-   12 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1149   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA