Coagulation factor XIII(Hegmen Factor) is a Medicine belongs to Blood Products Plasma Expanders and Haemostatics group whose information about Brand can be referenced from   Book : Martindale    Page : 1151   Edition : 38,

  ►   Brandname : Tisseel

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1150   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV injection or infusion,
Reference :-   Book : Martindale    Page : 1150   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Pre-operative use IV 35 units/kg Injection Given immediately before the operation.
2 Prophylaxis of haemorrhage IV 10 units/kg Injection Given once a month In patients with genetic deficiency.
3 Severe bleeding IV 10 20 units/kg Injection Given daily.
4 Intracranial bleeding IV Up to 50 units/kg Injection
5 Haemorrhage IV 15 20 units/kg Injection
6 Postoperative wound healing IV 10 units/kg Injection Given on the day of the operation and on each of the next 3 days.

Ref :-  Book : Martindale    Page : 1150   Edition : 38, Martindale    Page : 1151   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : chills, Urticaria, headache, allergic manifestations, hyperfibrinogenaemia, hepatitis, hypersensitivity reactions, thrombosis,
Ref :-   Book : Martindale    Page : 1151.1148   Edition : 38, Martindale    Page : 1151,1148   Edition : 38, Martindale    Page : 1151   Edition : 38,

►  Drug Interaction : Drug interaction of Coagulation factor XIII(Hegmen Factor) is with NA

  ►    Mechanism of Drug Drug Interaction :  NA


►  Contraindication : Patients who have developed neutralising antibodies to factor XIII,
Ref :-   Book : Martindale    Page : 1151   Edition : 38,
  ►  Mechanism of Action :   NA

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Spinach with Another pathway,

  ►  Pathway with its reference as follows :-
  • Spinach having vitamin K which help in coagulation of blood . --- (Gopalan, C. (2012). Nutritive value of Indian foods. National Institute of Nutrition ,ICMR.: Hyderabad 500007,INDIA. )

  •   ►  URL -- https://books.google.co.in/books?id=biFBAAAAYAAJ&q=Gopalan, +C., +Rama+Sastri, +B., +%26+Balasubramanian, +S.+(1971).+Nutritive+value+of+Indian+foods.+Hyderabad, +India:+National+Institute+of+Nutrition, +Indian+Council+of+Medical+R,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :
      Min value :-   11.8 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1151   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA