Cocaine is a Medicine belongs to Local anaesthetics group whose information about Brand can be referenced from   Book :

  ►   Brandname : NA

  ►  Strength : Solution with 40  mg/ml, Solution with 100  mg/ml, Powder with 5  gm, Powder with 25  gm, Eye Drop with   , Paste with 25  %, Tablets for Topical Solution with   , Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 463   Edition : 12, Martindale    Page : 1987   Edition : 38, Martindale    Page : 1984   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Topical, intranasal, IV,
Reference :-   Book : Martindale    Page : 1984   Edition : 38, Martindale    Page : 1987   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info

Ref :-  Book :




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : dilated pupils, tachycardia, hypertension, hallucinations, hypertonia, hyperreflexia, convulsion, coma, metabolic acidosis, corneal damage with clouding, pitting, sloughing, and occasionally ulceration, loss of smell, loss of taste, It is abusing and addiction drug,
Ref :-   Book : Martindale    Page : 1984   Edition : 38,

►  Drug Interaction : Drug interaction of Cocaine is with Monoamine Oxidase Inhibitor, Monoamine Oxidase Inhibitor,  Epinephrine (adrenaline) , Guanethidine,
Ref :-   Book : Martindale    Page : 1986   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Cocaine and adrenaline enhance each other’s sympathomimetic effects and should preferably not be used together. Caution is needed if cocaine is used with other drugs that may also potentiate the action of catecholamines such as guanethidine or MAOIs.,
Ref :-   Book : Martindale    Page : 1986   Edition : 38,


►  Contraindication : Breast feeding, damaged mucosa, pregnancy, eyes for prolonged periods as damage to the cornea, hypertension, cardiovascular disease, thyrotoxicosis,
Ref :-   Book : Martindale    Page : 1986   Edition : 38,
  ►  Mechanism of Action :   Cocaine, a benzoic acid ester, is a local anaesthetic It act by preventing the generation and transmission of impulses along nerve fibres and at nerve endings; depolarisation and ion-exchange are inhibited. Cocaine also blocks the uptake of catecholamines at adrenergic nerve endings and potentiates the action of catecholamines.,
Ref :-   Book : Martindale    Page : 1984   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Tea with Another pathway,

  ►  Pathway with its reference as follows :-
  • Tea having active constituent caffeine which act as stimulant . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1986   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   ~50 minutes,    Max value :-   NA
    Ref :-   Book : Goodman    Page : 662   Edition : 12,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA