Codeine is a Medicine belongs to opioid analgesics group whose information about Brand can be referenced from   Book : Martindale    Page : 42   Edition : 38,

  ►   Brandname : Codifos,Bepro,Galcodine; Lincotuss; Montokuf

  ►  Strength : Tablet with 15  mg, Tablet with 30  mg, Tablet with 60  mg, Injection with 15  mg/ml, Injection with 30  mg/ml, Solution with 15  mg/5mL, Capsule with   , Linctus with   , Elixir with   , Syrup with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 562   Edition : 12, Martindale    Page : 42   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, rectal, SC, IM,
Reference :-   Book : Martindale    Page : 40   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Pain Oral 30 60 mg Tablet Every 4 hours to a usual maximum of 240 mg daily.
2 Coughs Oral 15 30 mg t.i.d/q.i.d
3 Acute diarrhoea Oral 15 60 mg Tablet t.i.d/q.i.d

Ref :-  Book : Martindale    Page : 40   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Acute moderate pain over 12 Year Oral 30 60 mg q.i.d.
2 Acute diarrhoea over 12 Year Oral 15 60 mg t.i.d/q.i.d

Ref :- Book : Martindale    Page : 42   Edition : 38,
►  Side Effect : constipation, Excitation, convulsion, convulsion, dose-related histaminereleasing effect., ,
Ref :-   Book : Martindale    Page : 41   Edition : 38,

►  Drug Interaction : Drug interaction of Codeine is with Quinidine ,
Ref :-   Book : Martindale    Page : 42,111   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Quinidine can inhibit the analgesic effect of codeine.,
Ref :-   Book : Martindale    Page : 42,111   Edition : 38,


►  Contraindication : Acute respiratory depression, Obstructive airway disease, Acute alcoholism, convulsive disorder, Head injury, paralytic ileus, coma, Hypothyroidism, adrenocortical insufficiency, asthma, decreased respiratory reserve, renal impairment, hepatic impairment, prostatic hyperplasia, hypotension, shock, inflammatory or obstructive bowel disorders, myasthenia gravis, should be stopped gradually in patients who may have developed physical dependence,
Ref :-   Book : Martindale    Page : 42,110   Edition : 38,
  ►  Mechanism of Action :   ,
Ref :-   Book :    Page :    Edition : ,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- with same compound,

  ►  Pathway with its reference as follows :-
  • Morphine Sulphate --- (Samano, K., Clouette, R., Rowland, B., & Sample, R. (2015). Concentrations of Morphine and Codeine in Paired Oral Fluid and Urine Specimens Following Ingestion of a Poppy Seed Roll and Raw Poppy Seeds. Journal of Analytical Toxicology, 39(8), 655-661 )

  •   ►  URL -- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570939/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- TANNIN with Dietary Substance is Drug Inhibitor, CANNABIS with Dietary Substance is Drug Enhancer,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf, https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- KAVA with Cause excessive drawsinesss when taken with drug., DIETARY FIBER with A common side effect of narcotic analgesics , including codeine , is constipation . Increasing dietary fiber and water intake can ease constipation ., ALCOHOL with Drinking alcoholic beverage while taking alprazolam may increase side effects such as drowsiness , confusion , and dizziness .,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand.
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 42   Edition : 38,


    ►    Plasma Half-life :   Min value :-   3 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 42   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 42   Edition : 38,