Colloidal bismuth subcitrate (Bismuth compounds) is a Medicine belongs to Gastrointestinal drug group whose information about Brand can be referenced from   Book : Martindale    Page : 1823   Edition : 38  

  ►   Brandname : Trymo, De-Noltab, Pepto-Bismol, Bismatrol, Children’s Kaopectate, Devrom
  ►  Strength : Tablet with .  Paste with .  Magma with .  Suspension with .  Ointment with .  Suppository with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1823   Edition : 38   Martindale    Page : 1822   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical
Reference :-   Book : Martindale    Page : 1822   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Benign gastric ulceration Oral 240 mg b.d. or 120 mg four times daily before food.
2 Benign duodenal ulceration Oral 240 mg b.d. or 120 mg four times daily before food.

Ref :-  Book : Martindale    Page : 1822   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1

Ref :- Book :    Page :    Edition :   
►  Side Effect : Nausea, Vomiting, Gastrointestinal disturbance, Skin reactions, Stomatitis, Darkening or blackening of the faeces, Darkening or blackening of the tongue, Discoloration of mucous membranes, Reversible encephalopathy
Ref :-   Book : Martindale    Page : 1822   Edition : 38.  

►  Drug Interaction : Drug interaction of Colloidal bismuth subcitrate (Bismuth compounds) is with Tetracycline
Ref :-   Book : Martindale    Page : 1823   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  Bismuth salts given orally reduce the absorption of tetracyclines, possibly by chelation or by reducing tetracycline solubility as a result of increasing the gastric pH.
Ref :-   Book : Martindale    Page : 1823   Edition : 38.  


►  Contraindication : Moderate to severe renal impairment
Ref :-   Book : Martindale    Page : 1822   Edition : 38.  
  ►  Mechanism of Action :   Bismuth coats ulcers an erosions, creating a protective layer against acid and pepsin. It may also stimulate prostaglandin, mucus, and bicarbonate secretion. Bismuth has direct antimicrobial effects and binds enterotoxins and have direct antimicrobial activity against H pylori.
Ref :-   Book : Basic & Clinical pharmacology    Page : 1090   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Biliary, Fecal, Renal
Ref :-   Book : Martindale    Page : 1823   Edition : 38.  

►    Plasma Half-life :   Min value :-   5 days,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1823   Edition : 38.  

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA