Colloidal bismuth subcitrate (Bismuth compounds) is a Medicine belongs to Gastrointestinal drug group whose information about Brand can be referenced from   Book : Martindale    Page : 1823   Edition : 38,

  ►   Brandname : Trymo,De-Noltab,Pepto-Bismol,Bismatrol,Children’s Kaopectate,Devrom

  ►  Strength : Tablet with   , Paste with   , Magma with   , Suspension with   , Ointment with   , Suppository with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1823   Edition : 38, Martindale    Page : 1822   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical,
Reference :-   Book : Martindale    Page : 1822   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Benign gastric ulceration Oral 240 mg b.d. or 120 mg four times daily before food.
2 Benign duodenal ulceration Oral 240 mg b.d. or 120 mg four times daily before food.

Ref :-  Book : Martindale    Page : 1822   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : nausea, vomiting, gastrointestinal disturbance, Skin reactions, stomatitis, Darkening or blackening of the faeces, Darkening or blackening of the tongue, discoloration of mucous membranes, Reversible encephalopathy,
Ref :-   Book : Martindale    Page : 1822   Edition : 38,

►  Drug Interaction : Drug interaction of Colloidal bismuth subcitrate (Bismuth compounds) is with Tetracycline ,
Ref :-   Book : Martindale    Page : 1823   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Bismuth salts given orally reduce the absorption of tetracyclines, possibly by chelation or by reducing tetracycline solubility as a result of increasing the gastric pH.,
Ref :-   Book : Martindale    Page : 1823   Edition : 38,


►  Contraindication : moderate to severe renal impairment,
Ref :-   Book : Martindale    Page : 1822   Edition : 38,
  ►  Mechanism of Action :   Bismuth coats ulcers an erosions, creating a protective layer against acid and pepsin. It may also stimulate prostaglandin, mucus, and bicarbonate secretion. Bismuth has direct antimicrobial effects and binds enterotoxins and have direct antimicrobial activity against H pylori.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 1090   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- with Another pathway,

  ►  Pathway with its reference as follows :-
  • anti-ulcer effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary, Fecal, Renal,
    Ref :-   Book : Martindale    Page : 1823   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   5 days,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1823   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA