Conivaptan is a Medicine belongs to Cardiovascular-Renal Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 2486   Edition : 38  

  ►   Brandname : Vaprisol
  ►  Strength : Injection with 5 mg/ml.  Injection with 20/100 mg/ml. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 269   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV
Reference :-   Book : Basic & Clinical pharmacology    Page : 269   Edition : 12  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Hyponatremia IV infusion 20 mg Injection Over 30 minutes, followed by a continuous infusion of 20 mg over 24 hours.

Ref :-  Book : Martindale    Page : 2486   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1

Ref :- Book :    Page :    Edition :   
►  Side Effect : Erythema, Pain, Phlebitis, Swelling, Atrial fibrillation, GI disturbances, Pyrexia, Thirst, Electrolyte disturbances, Headache, Hypertension, Hypotension
Ref :-   Book : Martindale    Page : 2486   Edition : 38.  

►  Drug Interaction : Drug interaction of Conivaptan is with Amlodipine , Midazolam , Simvastatin , Ketoconazole , Itraconazole , Clarithromycin , Ritonavir, Indinavir, Digoxin
Ref :-   Book : Martindale    Page : 2486   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  Concentrations of conivaptan can be increased by CYP3A4 inhibitors. The use of conivaptan with potent CYP3A4 inhibitors such as ketoconazole, itraconazole, clarithromycin, ritonavir, and indinavir is contra-indicated. Conivaptan itself is also a potent inhibitor of CYP3A4 and may increase the concentrations of other substrates of this isoenzyme, including amlodipine, midazolam, and simvastatin. Conivaptan can reduce the clearance, and subsequently increase concentrations, of digoxin.
Ref :-   Book : Martindale    Page : 2486   Edition : 38.  


►  Contraindication : Hypovolemic hyponatremia, Renal impairment, Hepatic impairment
Ref :-   Book : Martindale    Page : 2486   Edition : 38.  
  ►  Mechanism of Action :   Vasopressin V1a and V2 receptor antagonist.
Ref :-   Book : Basic & Clinical pharmacology    Page : 677   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Garlic with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Cardioprotective effect . --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL --
  • http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal
    Ref :-   Book : Goodman    Page : 714   Edition : 12.  

    ►    Plasma Half-life :   Min value :-   5 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 2486   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   12 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 2486   Edition : 38.