Conjugated Oestrogens is a Medicine belongs to Sex hormones and their modulators group whose information about Brand can be referenced from   Book : Martindale    Page : 2261   Edition : 38  

  ►   Brandname : Espauz, Estrin; Climopox, Cenestin, Enjuvia, Premarin
  ►  Strength : Tablet with 0.3 mg.  Tablet with 0.45 mg.  Tablet with 0.625 mg.  Tablet with 0.9 mg.  Tablet with 1.25 mg.  Injection with 25/5 mg/ml.  Cream with 0.625 mg/gm. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 740   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Vaginal, IV, IM
Reference :-   Book : Basic & Clinical pharmacology    Page : 740   Edition : 12  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Menopausal HRT Oral 0.3 1.25 mg Tablet Daily.
2 Menopausal atrophic vaginitis Topical 0.5 2 gm Cream It is also used for the treatments of atrophic urethritis, and kraurosis vulvae. Daily for 3 weeks of a 4 week cycle.
3 Prostatic carcinoma Oral 1.25 2.5 mg Tablet t.i.d.
4 Abnormal uterine bleeding i.v/i.m 25 mg Injection Repeated if required after 6 to 12 hours.
5 Vasomotor symptoms associated with the menopause Oral 300 micrograms Tablet Daily.
6 Moderate to severe dyspareunia associated with menopausal vulvar atrophy Topical 0.5 gm Vaginal cream Twice weekly in a continuous regimen or daily for 3 weeks of a 4-week cycle.
7 Severe Vaginal dryness or dyspareunia associated with menopausal vulvar and vaginal atrophy Vaginal 1 gm Cream 0.0625 % vaginal cream may be used daily for 1 week followed by 1gm twice weekly.

Ref :-  Book : Martindale    Page : 2260   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
Precaution :- If a Patient is using 'Conjugated Oestrogens' drug in  Acute Intermittent Porphyria  disease, then Please Do not use .

►  Side Effect : Nausea, Fluid retention, Venous thrombosis, Arterial thrombosis, Cholestatic jaundice, Withdrawal bleeding, Hypercalcaemia, Bone pain, Premature closure of the epiphyses
Ref :-   Book : Martindale    Page : 2260,2273   Edition : 38.  

►  Drug Interaction : Drug interaction of Conjugated Oestrogens is with Antiepileptics ,  Rifamycin
Ref :-   Book : Martindale    Page : 2260,2251   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  Drugs that increase the hepatic metabolism of oestrogens and progestogens have been associated with failure of the combined oral contraceptive (see p.2067). Important examples include rifamycins, some antiepileptics
Ref :-   Book : Martindale    Page : 2260,2251   Edition : 38.  


►  Contraindication : Cerebrovascular disorder, Coronary artery disease, Venous thromboembolism., Premature closure of the epiphyses
Ref :-   Book : Martindale    Page : 2260,2273   Edition : 38.  
  ►  Mechanism of Action :  
Ref :-   Book :    Page :    Edition : .  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Clove with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Clove having estrogen effect . --- ( Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL --
  • Kokate .
  • C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary, Renal
    Ref :-   Book : Martindale    Page : 2261,2273   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

    ►    Peak Plasma Concentration :   Min value :-   1.5 hours,    Max value :-   2 hours.  
    Ref :-   Book : Martindale    Page : 2261,2273   Edition : 38.