Conjugated Oestrogens is a Medicine belongs to Sex hormones and their modulators group whose information about Brand can be referenced from   Book : Martindale    Page : 2261   Edition : 38,

  ►   Brandname : Espauz,Estrin; Climopox,Cenestin,Enjuvia,Premarin

  ►  Strength : Tablet with 0.3  mg, Tablet with 0.45  mg, Tablet with 0.625  mg, Tablet with 0.9  mg, Tablet with 1.25  mg, Injection with 25/5  mg/ml, Cream with 0.625  mg/gm,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 740   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Vaginal, IV, IM,
Reference :-   Book : Basic & Clinical pharmacology    Page : 740   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Menopausal HRT Oral 0.3 1.25 mg Tablet Daily.
2 Menopausal atrophic vaginitis Topical 0.5 2 gm Cream It is also used for the treatments of atrophic urethritis, and kraurosis vulvae. Daily for 3 weeks of a 4 week cycle.
3 Prostatic carcinoma Oral 1.25 2.5 mg Tablet t.i.d.
4 Abnormal uterine bleeding i.v/i.m 25 mg Injection Repeated if required after 6 to 12 hours.
5 Vasomotor symptoms associated with the menopause Oral 300 micrograms Tablet Daily.
6 Moderate to severe dyspareunia associated with menopausal vulvar atrophy Topical 0.5 gm Vaginal cream Twice weekly in a continuous regimen or daily for 3 weeks of a 4-week cycle.
7 Severe Vaginal dryness or dyspareunia associated with menopausal vulvar and vaginal atrophy Vaginal 1 gm Cream 0.0625 % vaginal cream may be used daily for 1 week followed by 1gm twice weekly.

Ref :-  Book : Martindale    Page : 2260   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
Precaution :- If a Patient is using 'Conjugated Oestrogens' drug in  Acute Intermittent Porphyria  disease, then Please Do not use .

►  Side Effect : nausea, fluid retention, venous thrombosis, arterial thrombosis, cholestatic jaundice, withdrawal bleeding, hypercalcaemia, bone pain, Premature closure of the epiphyses ,
Ref :-   Book : Martindale    Page : 2260,2273   Edition : 38,

►  Drug Interaction : Drug interaction of Conjugated Oestrogens is with Antiepileptics ,  Rifamycin,
Ref :-   Book : Martindale    Page : 2260,2251   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Drugs that increase the hepatic metabolism of oestrogens and progestogens have been associated with failure of the combined oral contraceptive (see p.2067). Important examples include rifamycins, some antiepileptics, ,
Ref :-   Book : Martindale    Page : 2260,2251   Edition : 38,


►  Contraindication : cerebrovascular disorder, coronary artery disease, venous thromboembolism., Premature closure of the epiphyses ,
Ref :-   Book : Martindale    Page : 2260,2273   Edition : 38,
  ►  Mechanism of Action :   ,
Ref :-   Book :    Page :    Edition : ,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Clove with Another pathway,

  ►  Pathway with its reference as follows :-
  • Clove having estrogen effect . --- ( Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan.,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary, Renal,
    Ref :-   Book : Martindale    Page : 2261,2273   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   1.5 hours,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 2261,2273   Edition : 38,