Conjugated Oestrogens is a Medicine belongs to Sex hormones and their modulators group whose information about Brand can be referenced from   Book : Martindale    Page : 2261   Edition : 38  

  ►   Brandname : Espauz, Estrin; Climopox, Cenestin, Enjuvia, Premarin
  ►  Strength : Tablet with 0.3 mg.  Tablet with 0.45 mg.  Tablet with 0.625 mg.  Tablet with 0.9 mg.  Tablet with 1.25 mg.  Injection with 25/5 mg/ml.  Cream with 0.625 mg/gm. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 740   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Vaginal, IV, IM
Reference :-   Book : Basic & Clinical pharmacology    Page : 740   Edition : 12  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Menopausal HRT Oral 0.3 1.25 mg Tablet Daily.
2 Menopausal atrophic vaginitis Topical 0.5 2 gm Cream It is also used for the treatments of atrophic urethritis, and kraurosis vulvae. Daily for 3 weeks of a 4 week cycle.
3 Prostatic carcinoma Oral 1.25 2.5 mg Tablet t.i.d.
4 Abnormal uterine bleeding i.v/i.m 25 mg Injection Repeated if required after 6 to 12 hours.
5 Vasomotor symptoms associated with the menopause Oral 300 micrograms Tablet Daily.
6 Moderate to severe dyspareunia associated with menopausal vulvar atrophy Topical 0.5 gm Vaginal cream Twice weekly in a continuous regimen or daily for 3 weeks of a 4-week cycle.
7 Severe Vaginal dryness or dyspareunia associated with menopausal vulvar and vaginal atrophy Vaginal 1 gm Cream 0.0625 % vaginal cream may be used daily for 1 week followed by 1gm twice weekly.

Ref :-  Book : Martindale    Page : 2260   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
Precaution :- If a Patient is using 'Conjugated Oestrogens' drug in  Acute Intermittent Porphyria  disease, then Please Do not use .

►  Side Effect : Nausea, Fluid retention, Venous thrombosis, Arterial thrombosis, Cholestatic jaundice, Withdrawal bleeding, Hypercalcaemia, Bone pain, Premature closure of the epiphyses
Ref :-   Book : Martindale    Page : 2260,2273   Edition : 38.  

►  Drug Interaction : Drug interaction of Conjugated Oestrogens is with Antiepileptics ,  Rifamycin
Ref :-   Book : Martindale    Page : 2260,2251   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  Drugs that increase the hepatic metabolism of oestrogens and progestogens have been associated with failure of the combined oral contraceptive (see p.2067). Important examples include rifamycins, some antiepileptics
Ref :-   Book : Martindale    Page : 2260,2251   Edition : 38.  


►  Contraindication : Cerebrovascular disorder, Coronary artery disease, Venous thromboembolism., Premature closure of the epiphyses
Ref :-   Book : Martindale    Page : 2260,2273   Edition : 38.  
  ►  Mechanism of Action :   The estrogen receptors are found predominantly in the nucleus bound to heat shock proteins that stabilize them. Binding of the hormone to its receptor alters its conformation and releases it from the stabilizing proteins. The receptor-hormone complex forms homodimers that bind to a specific sequence of nucleotides called estrogen response elements (EREs) in the promoters of various genes and regulate their transcription.
Ref :-   Book : Basic & Clinical pharmacology    Page : 719   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Clove with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Clove having estrogen effect . --- ( Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL --
  • Kokate .
  • C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary, Renal
    Ref :-   Book : Martindale    Page : 2261,2273   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

    ►    Peak Plasma Concentration :   Min value :-   1.5 hours,    Max value :-   2 hours.  
    Ref :-   Book : Martindale    Page : 2261,2273   Edition : 38.