Corticotropin is a Medicine belongs to Corticosteroid group whose information about Brand can be referenced from   Book : Martindale    Page : 1629   Edition : 38,

  ►   Brandname : Acthar; Acton Prolongatum

  ►  Strength : Injection with 80  units/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 678   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, SC, IM,
Reference :-   Book : Martindale    Page : 1629   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Diagnostic purposes IV infusion 10 25 units Injection 500 mL of glucose 5% infused intravenously over 8 hours.
2 Therapeutic purposes s.c/ i.m 40 80 units Injection Every 24 to 72 hours.

Ref :-  Book : Martindale    Page : 1629   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : sensitisation, severe hypersensitivity reaction,
Ref :-   Book : Martindale    Page : 1628   Edition : 38,

►  Drug Interaction : Drug interaction of Corticotropin is with Barbiturates , Oral Contraceptive, Thiazide Diuretics , xanthine/ bronchodilator , Beta 2 Agonist, NSAIDS, Anticoagulant , Antidiabetic , Antihypertensive Agents , Salicylates, Anticholinesterase,  Amphotericin B , Phenytoin , Primidone , Rifampicin , Ritonavir, Furosemide , Mifepristone ,
Ref :-   Book : Martindale    Page : 1628,1619   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Concurrent use of barbiturates, carbamazepine, phenytoin, primidone, or rifampicin may enhance the metabolism and reduce the effects of systemic Corticotropin . Conversely oral contraceptives or ritonavir may increase plasma concentrations of Corticotropin. Use of Corticotropin with potassium-depleting diuretics, such as thiazides or furosemide, may cause excessive potassium loss. There is also an increased risk of hypokalaemia with concurrent amphotericin B or bronchodilator therapy with xanthines or beta2 agonists. There may be an increased incidence of gastrointestinal bleeding and ulceration when Corticotropin are given with NSAIDs. Response to anticoagulants may be altered by Corticotropin and requirements of antidiabetic drugs and antihypertensives may be increased. Corticotropin may decrease serum concentrations of salicylates and may decrease the effect of anticholinesterases in myasthenia gravis. The antiglucocorticoid effect of mifepristone will antagonize the effect of Corticotropin.,
Ref :-   Book : Martindale    Page : 1628,1619   Edition : 38,


►  Contraindication : heart failure, recent myocardial infarction, hypertension, Diabetes mellitus, Epilepsy, acute infections uncontrolled by appropriate antimicrobial therapy, Quiescent tuberculosis, Live vaccines,
Ref :-   Book : Martindale    Page : 1628,1619   Edition : 38,
  ►  Mechanism of Action :   Corticotropin is a naturally occurring hormone of the anterior lobe of the pituitary gland. It stimulates the adrenal glands to secrete adrenocortical hormones, especially cortisol (hydrocortisone), some mineralocorticoids such as corticosterone and to a lesser extent, androgens. ,
Ref :-   Book : Martindale    Page : 1628   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   NA


►    Plasma Half-life :
  Min value :-   NA    Max value :-   NA


►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA