Cortisone is a Medicine belongs to Corticosteroid group whose information about Brand can be referenced from   Book : Martindale    Page : 1629   Edition : 38,

  ►   Brandname : Cortisyl,Cortone

  ►  Strength : Tablet with 25  mg, Injectable Suspension with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 712   Edition : 12, Martindale    Page : 1629   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM,
Reference :-   Book : Martindale    Page : 1629   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Oral replacement therapy Oral 12.5 37.5 mg Tablet Daily in divided doses.
2 Allergic and inflammatory disorders IM 25 300 mg Injection Daily.

Ref :-  Book : Martindale    Page : 1629   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : oedema, hypertension, Disturbances of electrolyte balance, menstrual irregularities, amenorrhoea, Hyperhidrosis, skin thinning, ocular changes, glaucoma, cataract, mental disturbances, neurological disturbances, benign intracranial hypertension, acute pancreatitis, avascular necrosis of bone, hypokalaemic alkalosis,
Ref :-   Book : Martindale    Page : 1629,1616   Edition : 38,

►  Drug Interaction : Drug interaction of Cortisone is with Barbiturates , Oral Contraceptive, Thiazide Diuretics , xanthine/ bronchodilator , Beta 2 Agonist, NSAIDS, Anticoagulant , Antidiabetic , Antihypertensive Agents , Beta 2 Agonist, Salicylates,  Carbamazapine , Phenytoin , Primidone , Rifampicin , Ritonavir, Furosemide , Amphotericin B , Mifepristone ,
Ref :-   Book : Martindale    Page : 1629,1619   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Concurrent use of barbiturates, carbamazepine, phenytoin, primidone, or rifampicin may enhance the metabolism and reduce the effects of systemic Cortisone . Conversely oral contraceptives or ritonavir may increase plasma concentrations of Cortisone . Use of Cortisone with potassium-depleting diuretics, such as thiazides or furosemide, may cause excessive potassium loss. There is also an increased risk of hypokalaemia with concurrent amphotericin B or bronchodilator therapy with xanthines or beta2 agonists. There may be an increased incidence of gastrointestinal bleeding and ulceration when Cortisone are given with NSAIDs. Response to anticoagulants may be altered by Cortisone and requirements of antidiabetic drugs and antihypertensives may be increased. Cortisone may decrease serum concentrations of salicylates and may decrease the effect of anticholinesterases in myasthenia gravis. The antiglucocorticoid effect of mifepristone will antagonize the effect of Cortisone.,
Ref :-   Book : Martindale    Page : 1629,1619   Edition : 38,


►  Contraindication : heart failure, recent myocardial infarction, hypertension, Diabetes mellitus, Epilepsy, acute infections uncontrolled by appropriate antimicrobial therapy, Quiescent tuberculosis, Live vaccines,
Ref :-   Book : Martindale    Page : 1629,1618   Edition : 38,
  ►  Mechanism of Action :   ,
Ref :-   Book :    Page :    Edition : ,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism),
Ref :-   Book : Martindale    Page : 1629   Edition : 38,


►    Plasma Half-life :
  Min value :-   30 minutes,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1629   Edition : 38,

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA