Cyclizine is a Medicine belongs to Antihistamine (H1 blocker) group whose information about Brand can be referenced from   Book : Martindale    Page : 624   Edition : 38,

  ►   Brandname : Bonine for Kids,Marezine,valoid; Medazine

  ►  Strength : Tablet with 50  mg, Injection with   , Suppository with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 292   Edition : 12, Martindale    Page : 623   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, IM, SC, rectal,
Reference :-   Book : Martindale    Page : 623   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Nausea and vomiting Oral 50 mg Tablet t.i.d.
2 Motion sickness Oral 50 mg Tablet Given about 30 minutes before travelling.
3 Postoperative nausea and vomiting Oral 50 mg Tablet Given about 20 minutes before the anticipated end of surgery.

Ref :-  Book : Martindale    Page : 623   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Nausea and vomiting 6 Year 12 Year Oral 25 mg Tablet t.i.d.
2 Nausea and vomiting 1 Month 2 Year s.c or i.v 3 mg/kg Injection
3 Nausea and vomiting 2 Year 5 Year s.c or i.v 50 mg Injection
4 Nausea and vomiting 6 Year 12 Year s.c or i.v 75 mg Injection
5 Nausea and vomiting 12 Year 18 Year s.c or i.v 150 mg Injection
6 Nausea and vomiting 1 Month 6 Year Oral 0.5 1 mg/kg Tablet t.i.d.

Ref :- Book : Martindale    Page : 623   Edition : 38,
►  Side Effect : CNS depression, slight drowsiness to deep sleep, lassitude, Dizziness, incoordination, headache, psychomotor impairment, dry mouth, thickened respiratory-tract secretions, Blurred Vision, urinary difficulty or retention, constipation, increased gastric reflux, convulsion, sweating, myalgia, paraesthesia, extrapyramidal effects, tremor, Sleep disturbances, Depression, Confusion, tinnitus, Hypotension may occur on injection, hair loss, nausea, vomiting, diarrhea, epigastric pain, palpitations, arrhythmia, agranulocytosis, leucopenia, haemolytic anaemia, thrombocytopenia, hypersensitivity reactions, bronchospasm, angioedema, anaphylaxis, severe heart failure,
Ref :-   Book : Martindale    Page : 611, 625   Edition : 37,

►  Drug Interaction : Drug interaction of Cyclizine is with Alcohol, Barbiturates , Hypnotic , opioid analgesics, Anxiolytic sedatives, Antipsychotic , Tricyclic antidepressant , Monoamine Oxidase Inhibitor,  Atropine ,
Ref :-   Book : Martindale    Page : 624,614   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Sedating antihistamines may enhance the sedative effects of CNS depressants including alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives, and antipsychotics. Sedating antihistamines have an additive antimuscarinic action with other antimuscarinic drugs, such as atropine and some antidepressants (both tricyclics and MAOIs).,
Ref :-   Book : Martindale    Page : 624,614   Edition : 38,


►  Contraindication : heart failure, susceptibility to QT-interval prolongation, Hypokalaemia, electrolyte imbalance, those affected should not drive or operate machinery, alcohol should be avoided,
Ref :-   Book : Martindale    Page : 623,613   Edition : 38,
  ►  Mechanism of Action :   Inverse agonist that bind preferentially to the inactive conformation of the H1 receptor and shift the equilibrium toward the inactive receptor state.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 774   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Onion with same pathway,

  ►  Pathway with its reference as follows :-
  • antihistamine effect . --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- KAVA KAVA with It may cause excessive drowsiness when taken with this drug .,

      ►  Reference :-
  • Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan.

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 624   Edition : 38,


    ►    Plasma Half-life :   Min value :-   20 Hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 624   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA