Cyclophosphamide is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 774   Edition : 38,

  ►   Brandname : Cycloxan; Cycrame,Cydoxan,Eldamide

  ►  Strength : Injection with   , Tablet with   , Oral solution with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 774   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 770   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Chemotherapy IV 2 6 mg/kg Injection QWK
2 Chemotherapy IV 10 15 mg/kg Injection QWK
3 Chemotherapy IV 20 40 mg/kg Injection Every 10 to 20 days.
4 Chemotherapy Oral 2 6 mg/kg Tablet In divided dose.

Ref :-  Book : Martindale    Page : 770   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Myelosuppression, thrombocytopenia, anaemia, haemorrhagic cystitis, Alopecia occurs in about 20% of patients given low doses and in practically all patients given high doses., Hyperpigmentation of skin, especially that of the palms and soles, and of the nails, nausea, vomiting, Inappropriate secretion of antidiuretic hormone, carcinogenic, mutagenic, and teratogenic potential and secondary malignancies have occurred in patients given previous antineoplastic therapy including cyclophosphamide., local pain, Irritation, inflammation at the administration site, extravasation may lead to ulceration and necrosis., hypersensitivity reactions,
Ref :-   Book : Martindale    Page : 772   Edition : 38, Martindale    Page : 773,726   Edition : 38,

►  Drug Interaction : Drug interaction of Cyclophosphamide is with Cardiotoxic drugs, ,  Doxorubicin,
Ref :-   Book : Martindale    Page : 773   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  cyclophosphamide must undergo hepatic metabolism before it is active, interactions are possible with drugs that inhibit or stimulate the mixed function oxidase enzymes responsible. There may be an increased risk of cardiotoxicity in patients who have also received doxorubicin or other cardiotoxic drugs.,
Ref :-   Book : Martindale    Page : 773   Edition : 38,


►  Contraindication : Severely depressed bone marrow function,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 696   Edition : 3,
  ►  Mechanism of Action :   Covalently bind DNA, often cross link to DNA or associated proteins.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 696   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Vinca with Another pathway,

  ►  Pathway with its reference as follows :-
  • It arrests multiplication of cancerous cells by breaking down the microtubules into smaller subunits, thus inhibiting the cell division. --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Fecal, Hepatic (Metabolism),
    Ref :-   Book : Goodman    Page : 1683   Edition : 12,


    ►    Plasma Half-life :
      Min value :-   7 hours,    Max value :-   NA
    Ref :-   Book : Goodman    Page : 1683   Edition : 12,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   NA
    Ref :-   Book : Goodman    Page : 1683   Edition : 12,