Cycloserine is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 280   Edition : 38,

  ►   Brandname : Cyclorine,Cycloserine,Seromycin

  ►  Strength : Capsule with 250  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 848   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 280   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Tuberculosis Oral 250 mg Capsule b.d. For 2 weeks, followed by 0.5 to 1 g daily in divided doses.

Ref :-  Book : Martindale    Page : 280   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Tuberculosis Oral 10 20 mg/kg/day Capsule

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1008   Edition : 19,
►  Side Effect : cycloserine involve the CNS and include anxiety, confusion, disorientation, depression, psychoses possibly with suicidal tendencies, aggression, irritability, and paranoia., Vertigo, headache, drowsiness, speech difficulties, tremor, paresis, hyperreflexia, dysarthria, paraesthesia, coma, and convulsions, , , Serum aminotransferase values may be raised, especially in patients with a history of liver disease, Folate and vitamin B12 deficiency, megaloblastic anaemia, and sideroblastic anaemia have been reported occasionally when cycloserine has been used with other antituberculous drugs., Heart failure has occurred in patients receiving daily doses of 1 g or more.,
Ref :-   Book : Martindale    Page : 280   Edition : 38,

►  Drug Interaction : Drug interaction of Cycloserine is with Alcohol,  Ethionamide , Isoniazid ,
Ref :-   Book : Martindale    Page : 281   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Patients receiving cycloserine and taking alcohol are at increased risk of convulsions. Neurotoxic effects may be potentiated by use of cycloserine with ethionamide and concurrent use of cycloserine and isoniazid may result in increased CNS toxicity, such as dizziness and drowsiness,
Ref :-   Book : Martindale    Page : 281   Edition : 38,


►  Contraindication : Epilepsy, depression, Psychoses, severe anxiety, severe renal impairment, in those who misuse alcohol, skin reactions, symptoms of CNS toxicity develop.,
Ref :-   Book : Martindale    Page : 280   Edition : 38,
  ►  Mechanism of Action :   Cycloserine and d-alanine are structural analogs; thus cycloserine inhibits alanine racemase which converts L-alanine to d-alanine and d-alanine: d-alanine ligase, stopping reactions in which d-alanine is incorporated into bacterial cell-wall synthesis. ,
Ref :-   Book : Goodman    Page : 1562   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Garlic with Another pathway,

  ►  Pathway with its reference as follows :-
  • antitubercular effect . --- (cytotoxicity and antitubercular activity of allium sativum and lantana camara against mycobacterial isolates from people living with HIV/AIDS. (2010). The Internet Journal Of Infectious Diseases, 8(1). doi:10.5580/26a8 )

  •   ►  URL -- http://ispub.com/IJID/8/1/12922,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- CALCIUM with Decrease in Nutrient Level, MAGNESIUM with Decrease in Nutrient Level, VITAMIN B6 with Decrease in Nutrient Level, VITAMIN B2 with Increase in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- VITAMIN K with Many antibiotics taken by mouth , including cycloerine , may kill friendly bacteria in the large intestine that produce vitamin K ., VITAMIN B12 with Impairs vitamin metabolism., VITAMIN B12 with Impairs vitamin B6 metabolism & increases urinary excretion .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf, http://197.14.51.10:81/pmb/AGROALIMENTAIRE/Handbook%20of%20Nutrition.pdf,

    ►   Route of Elimination :   Renal, Fecal,
    Ref :-   Book : Martindale    Page : 281   Edition : 38,    Page :    Edition : ,


    ►    Plasma Half-life :   Min value :-   10 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 281   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   3 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 281   Edition : 38,