Cyproheptadine is a Medicine belongs to antihistamines group whose information about Brand can be referenced from   Book : Martindale    Page : 624   Edition : 38,    Page :   Edition : ,

  ►   Brandname : Apenorm,Ciplactin,Peritol,Practin,Periactin,Aptimust,CYP- L,Novogold

  ►  Strength : Tablet with 4  mg, Syrup with 2/5  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 292   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 624   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Allergic conditions Oral 4 mg Tablet t.i.d.
2 Pruritus Oral 4 mg Tablet t.i.d.
3 Prophylaxis of migraine Oral 4 mg Tablet
4 Vascular headaches Oral 4 mg Tablet

Ref :-  Book : Martindale    Page : 624   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Allergic conditions 2 Year 6 Year Oral 2 mg Tablet b.d/t.i.d
2 Pruritus 2 Year 6 Year Oral 2 mg Tablet b.d/t.i.d
3 Pruritus 7 Year 14 Year Oral 4 mg Tablet b.d/t.i.d
4 Allergic conditions 7 Year 14 Year Oral 4 mg Tablet b.d/t.i.d

Ref :- Book : Martindale    Page : 624   Edition : 38,
►  Side Effect : Sedation, Dizziness, pupillary dilation, dry mouth, urinary retention, urinary hesitancy, dry eyes,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 774   Edition : 3,

►  Drug Interaction : Drug interaction of Cyproheptadine is with Alcohol, Barbiturates , Hypnotic , opioid analgesics, Anxiolytic sedatives, Antipsychotic , Tricyclic antidepressant , Monoamine Oxidase Inhibitor,  NA

  ►    Mechanism of Drug Drug Interaction :  Cyproheptadine may enhance the sedative effects of CNS depressants including alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives, and antipsychotics. Cyproheptadine have an additive antimuscarinic action with other antimuscarinic drugs, such as atropine and some antidepressants (both tricyclics and MAOIs). ,
Ref :-   Book : Martindale    Page : 624,614   Edition : 38,


►  Contraindication : angle -closure glucoma, Concurrent MAOI therapy, new born or premature infants, nursing mothers, stenosing peptic ulcer, symptomatic prostatic hypertrophy, bladder neck obstruction,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 774   Edition : 3,
  ►  Mechanism of Action :   Inverse agonists that bind preferentially to the inactive conformation of the H1 receptor and shift the equilibrium toward the inactive receptor state. Cyproheptadine, a piperidine derivative, is a sedating antihistamine with antimuscarinic, serotonin-antagonist, and calcium-channel blocking actions. ( Martindale, 624, 38),
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 774   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Quercetin with Another pathway,

  ►  Pathway with its reference as follows :-
  • antihistamic effect --- ( E, H. (2003). The effect of herbal water extract on histamine release from mast cell on allergy asthama. Journal Of Herbal Pharmacotherapy, 3(4), 41-55. )

  •   ►  URL -- http://www.ncbi.nlm.nih.gov/pubmed/15277119,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- FISH OIL with , AIR PLANT I E AMAR POI with ,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand.

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, ,

    ►   Route of Elimination :   Renal, Faecal,
    Ref :-   Book : Martindale    Page : 624   Edition : 38,


    ►    Plasma Half-life :   Min value :-   1 ,    Max value :-   4 hours,
    Ref :-   Book : Goodman    Page : 1816   Edition : 12,


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA