Cytosine arabinoside (Cytarabine) is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 775   Edition : 38,

  ►   Brandname : Cancyt,Cybin; Cytarine; Biobin; Depocyte

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 776   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV infusion, intrathecal ,
Reference :-   Book : Martindale    Page : 774   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Acute leukaemias IV 100 mg/m2 Injection b.d. or 100 mg/m2 daily by continuous intravenous infusion ,both for 7 days ,are used in combination regimen for acute myeloid leukaemia, Cytarabine 200 mg/m2 by continuous intraveinous infusion for 5 days at intervals of about 2 weeks has also been used as monotherapy.
2 Non Hodgkin’s lymphoma IV infusion 3 gm/m2 Injection b.d. For up to 12 doses, should be given by intravenous infusion over at least 1 hour.
3 Meningenal leukaemia intrathecal 5 75 mg/m2 Injection 30 to 100 mg, once every 2 to 7 days to once daily for 4 or 5 days.

Ref :-  Book : Martindale    Page : 774    Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Bone marrow suppression, GI disturbances, leukopenia, thrombocytopenia, anemia, Myelosuppression after continuous infusions, hepatic dysfunction, Renal dysfunction, nephrotoxicity, Bleeding complications, Rashes, oral and anal ulceration, gastrointestinal haemorrhage, oesophagitis, conjunctivitis, muscle pain, malaise, , SometImes with striking megaloblastic changes.,
Ref :-   Book : Martindale    Page : 775   Edition : 38,

►  Drug Interaction : Drug interaction of Cytosine arabinoside (Cytarabine) is with ,  vaccine ,  Flucytosine ,
Ref :-   Book : Martindale    Page : 775,733   Edition : 38, Martindale    Page : 775   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Cytosine arabinoside (Cytarabine) may inhibit the action of Flucytosine. Antineoplastics that have an immunosuppressant effect may reduce the response to vaccines, and there is a possibility of generalised infection with live vaccines. Use with live vaccines should generally be avoided,
Ref :-   Book : Martindale    Page : 775,733   Edition : 38,


►  Contraindication : Pregnancy, Mothers receiving antineoplastic therapy should not breast feed, severe pain and tissue damage,
Ref :-   Book : Martindale    Page : 775,732   Edition : 38,
  ►  Mechanism of Action :   Cytarabine, a pyrimidine nucleoside analogue, is an antimetabolite antineoplastic that inhibits the synthesis of deoxyribonucleic acid. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties,
Ref :-   Book : Martindale    Page : 775   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Pacific yew bark i.e.Taxol with Another pathway,

  ►  Pathway with its reference as follows :-
  • Pacitaxel have anticancer effect --- (Kokate, C.K. and A.p. Purohit. Pharmacognosy. Nirali prakashan: Chennai, 2013. Print. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- VITAMIN K with Decrease in Nutrient Level, MAGNESIUM with Decrease in Nutrient Level, POTASSIUM with Decrease in Nutrient Level,

      ►  Reference :-
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- http://197.14.51.10:81/pmb/AGROALIMENTAIRE/Handbook%20of%20Nutrition.pdf, http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- GLUTAMINE with Though cancer cells use glutamine as a fuel source , So supplement glutamin with diet it reduced side effect of drug mouth sores .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 774   Edition : 38,


    ►    Plasma Half-life :   Min value :-   1-3 hours (the terminal elimination half-life),    Max value :-   After intrathecal doses of the liposomal formulation, a terminal elimination half-life of 100 to 263 hours,,
    Ref :-   Book : Martindale    Page : 774    Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA