Dacarbazine is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 773   Edition : 37,

  ►   Brandname : DTIC-dome,Decarin,Decarb

  ►  Strength : Injection with 200  mg,

Reference of this Medicine for its Strength can be taken from   Book :    Page :    Edition : ,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 773   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Soft-tissue sarcoma IV 250 mg/m2 Injection Dose: Given daily for 5 days repeated every 3 weeks; it is usually given with doxorubicin.
2 Hodgkin’s disease IV 150 mg/m2 Injection Dose: Given daily for 5 days repeated every 4 weeks, or 375 mg/m2 every 15 days have been given with other agents.
3 Metastatic melanoma IV 2 4.5 mg/kg Injection Dose: given daily for 10 days, repeated at intervals of 4 weeks, or 200 to 250 mg/m2 daily for 5 days, repeated at intervals of 3 weeks.
4 Metastatic melanoma IV infusion 850 mg/m2 Injection Dose: Given at 3-week intervals.

Ref :-  Book : Martindale    Page : 774   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : nausea, vomiting, flu-like syndrome, alopecia, facial flushing, fatal hepatotoxicity, anorexia, anaphylaxis, paraesthesia, Blurred Vision, headache, diarrhoea, Skin reactions, seizures, Local pain at injection site,
Ref :-   Book : Martindale    Page : 774   Edition : 37,

►  Drug Interaction : Drug interaction of Dacarbazine is with Antineoplastic , ,  Levodopa ,
Ref :-   Book : Martindale    Page : 774   Edition : 37, Martindale    Page : 698   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Many antineoplastics are inhibitors of certain isoenzymes of cytochrome P450 and some antineoplastics are also metabolised by these enzymes, and in consequence the possibility of interactions between antineoplastics, or between antineoplastics and other medication, cannot be discounted. A patient with Parkinson’s disease noted that the efficacy of levodopa was reduced each time he received dacarbazine for the treatment of melanoma.,
Ref :-   Book : Martindale    Page : 773   Edition : 37,


►  Contraindication : hepatic impairment, renal impairment,
Ref :-   Book : Martindale    Page : 774   Edition : 37,
  ►  Mechanism of Action :   Dacarbazine is a cell-cycle non-specific antineoplastic that is thought to function as an alkylating agent after it has been activated in the liver. It covalently bind DNA, often cross-link to DNA or associated proteins. Ref 7 pg no 696. ed 3,
Ref :-   Book : Martindale    Page : 773   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Ashwagandha with Another pathway,

  ►  Pathway with its reference as follows :-
  • Anticancer --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- MAGNESIUM with Decrease in Nutrient Level, POTASSIUM with Decrease in Nutrient Level,

      ►  Reference :-
  • Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan.
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html, http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- GLUTAMINE with It reduce side effect of the day ., GLUTAMINE with It decrease the kidney and bladder toxicity of the chemotherapy drug .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 773   Edition : 37,


    ►    Plasma Half-life :   Min value :-   20 minutes,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 774   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA