Dactinomycin (Actinomycin D) is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 775   Edition : 37,

  ►   Brandname : Dacmozen,Cosmegen

  ►  Strength : Injection with 500  micrograms,

Reference of this Medicine for its Strength can be taken from   Book :    Page :    Edition : ,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 775   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Wilm’s tumor IV 15 mcg/kg Injection Dose: Given daily for 5 days has been used in combination regimens.
2 Ewing’s sarcoma IV 15 mcg/kg Injection Dose: Given daily for 5 days has been used in combination regimens.
3 Childhood rhabdomyosarcoma IV 15 mcg/kg Injection Dose: Given daily for 5 days has been used in combination regimens.
4 Gestational trophoblastic tumours IV 12 mcg/kg Injection Dose: Given daily for 5 days as a single agent, or 500 micrograms on days 1 and 2 of combination regimens.
5 Metastatic nonseminomatous testicular cancer IV 1 mg/m2 Injection Dose: Given on day 1 of combination regimens.

Ref :-  Book : Martindale    Page : 775   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : cheilitis, oesophagitis, gastrointestinal ulceration, proctitis, fever, malaise, hypocalcaemia, erythema, myalgia, alopecia, pneumonitis, kidney and liver abnormalities, fatal hepatic failure, Anaphylactoid reactions,
Ref :-   Book : Martindale    Page : 774   Edition : 37,

►  Drug Interaction : Drug interaction of Dactinomycin (Actinomycin D) is with vaccine , ,  NA

  ►    Mechanism of Drug Drug Interaction :  Because of their effects on the gastrointestinal mucosa antineoplastics have the potential to interfere with the absorption of drugs given orally. Antineoplastics that have an immunosuppressant effect may reduce the response to vaccines, and there is a possibility of generalised infection with live vaccines.Many antineoplastics are inhibitors of certain isoenzymes of cytochrome P450 and some antineoplastics are also metabolised by these enzymes, and in consequence the possibility of interactions between antineoplastics, or between antineoplastics and other medication, cannot be discounted.,
Ref :-   Book : Martindale    Page : 698   Edition : 37,


►  Contraindication : avoided in infants under 1 year , Avoided in patients with varicella or herpes zoster, as severe and even fatal systemic disease, Dactinomycin should not be given to patients with varicella or herpes zoster, as severe and even fatal systemic disease may occur, avoided in infants under 1 year ,
Ref :-   Book : Martindale    Page : 775   Edition : 37, Martindale    Page : 774   Edition : 37,
  ►  Mechanism of Action :   Dactinomycin is a highly toxic antibiotic with antineoplastic properties. It inhibits the proliferation of cells in a cell-cycle non-specific way by forming a stable complex with DNA and interfering with DNA-dependent RNA synthesis,
Ref :-   Book : Martindale    Page : 775   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Cabbage with Another pathway,

  ►  Pathway with its reference as follows :-
  • crude protein extract have antimicrobial activity --- ( Hu, S., Wang, J., Kung, H., Wang, J., Lee, W., & Yang, Y. (2004). Antimicrobial Effect of Extracts of Cruciferous Vegetables. The Kaohsiung Journal Of Medical Sciences, 20(12), 591-599. )

  •   ►  URL -- http://www.sciencedirect.com/science/article/pii/S1607551X09702645,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary, Renal,
    Ref :-   Book : Martindale    Page : 775   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   36 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 775   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,