Danazol is a Medicine belongs to Sex harmones and their modulators group whose information about Brand can be referenced from   Book : Martindale    Page : 2298   Edition : 37, Basic & Clinical pharmacology    Page : 740   Edition : 12,

  ►   Brandname : Zendol,Danol,Danocrine,Danogen,Gonablok

  ►  Strength : Capsule with 50  mg, Capsule with 100  mg, Capsule with 200  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 740   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 2296   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Endometriosis Oral 200 800 mg Capsule Dose: Given daily in 2 to 4 divided doses
2 Benign breast disorders Oral 100 400 mg Capsule Dose: Given daily in 2 divided doses
3 Hereditary angioedema Oral 200 mg Capsule b.d/t.i.d
4 Pre-operative thinning of the endometrium Oral 400 800 mg Capsule Dose: Given daily in up to 4 divided doses
5 Gynaecomastia Oral 400 mg Capsule Dose: given daily initially up to 4 divided doses.
6 Menorrhagia Oral 200 mg Capsule Dose: Given daily.

Ref :-  Book : Martindale    Page : 2296   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Hereditary angioedema Oral 200 mg Capsule o.d/b.d
2 Gynaecomastia Oral 200 mg Capsule

Ref :- Book : Martindale    Page : 2297   Edition : 37, Martindale    Page : 2296   Edition : 37,
►  Side Effect : menstrual disturbances, amenorrhoea, hot flushes, sweating, reduction in breast size, changes in libido, vaginal dryness and irritation, emotional lability, Nervousness, acne, oily skin or hair, mild hirsutism, oedema, weight gain, deepening of the voice, androgenic alo-pecia, clitoral hypertrophy, testicular atrophy, reduction in spermatogenesis, gastrointestinal disturbance, thrombotic events, headache, backache, tremor, Dizziness, Depression, fatigue, sleep disorders, muscle spasm or cramp, Skin rashes, hyperglucagonaemia, ab-normal glucose tolerance, decreased serum high-densi- ty-lipoprotein cholesterol, increased serum low-densi- ty-lipoprotein cholesterol, elevation of liver-function test values, cholestatic jaundice, palpitations, tachycardia, hypertension, benign intracranial hypertension, visual disturbances, increased or decreased blood cell counts,
Ref :-   Book : Martindale    Page : 2295   Edition : 37,

►  Drug Interaction : Drug interaction of Danazol is with Statins,  Carbamazapine , Cyclosporine , Warfarin , Alfacalcidol, Tacrolimus ,
Ref :-   Book : Martindale    Page : 2296   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Danazol may inhibit the hepatic metabolism of several drugs including carbamazepine , ciclosporin , and possibly tacrolimus. Danazol may also enhance the effects of warfarin. Introduction of danazol appeared to reduce the maintenance requirement for alfacalcidol. Rhabdomyolysis has been attributed to use of danazol with statins.,
Ref :-   Book : Martindale    Page : 2296   Edition : 37,


►  Contraindication : used with care in patients with diabetes mellitus, poly- cythaemia, abnormal blood lipids, migraine, or epilepsy, used with caution in conditions that may be adversely affected by fluid retention, such as in cardiovascular, hepatic, and renal disorders, Pregnancy, patients with undi agnosed genital bleeding or androgen-dependent tumours,
Ref :-   Book : Martindale    Page : 2296   Edition : 37,
  ►  Mechanism of Action :   Danazol binds to androgen, progesterone, and glucocorticoid receptors and can translocate the androgen receptor into the nucleus to initiate androgen-specific RNA synthesis. It does not bind to intracellular estrogen receptors, but it does bind to sex hormone binding and corticosteroid-binding globulins. It inhibits P450scc (the cholesterol side chain-cleaving enzyme), 3β-hydroxysteroid dehydrogenase, 17α-hydroxysteroid dehydrogenase, P450c17 (17α-hydroxylase), P450c11 (11β-hydroxylase), and P450c21 (21β-hydroxylase). However, it does not inhibit aromatase, the enzyme required for estrogen synthesis.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 732   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Soyabean with Another pathway, Sclerocarya birrea with same pathway,

  ►  Pathway with its reference as follows :-
  • Phytoestrogens (Soyabeans) bind estrogen receptors. --- ( Araújo, A. (2016). Pharmacognosy C.K.Kokate Free Download | Free Pharma Downloads. Freepharmadownloads.blogspot.com. Retrieved 3 August 2016, )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744903/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Faecal, Renal,
    Ref :-   Book : Martindale    Page : 2296   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   3 hours,    Max value :-   6 hours,
    Ref :-   Book : Martindale    Page : 2296   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA