Dantrolene Sodium is a Medicine belongs to muscle relaxant (Spasmolytic) group whose information about Brand can be referenced from   Book : Martindale    Page : 2061   Edition : 37,

  ►   Brandname : Dantrium

  ►  Strength : Capsule with 25  Mg, Capsule with 50  mg, Capsule with 100  mg, Injection with 20  mg, Oral Suspension with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 481   Edition : 12, Martindale    Page : 2061   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 2060   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Spasticity Oral 25 mg Dose: Given daily.
2 Malignant hyperthermia IV 1 mg/kg Injection

Ref :-  Book : Martindale    Page : 2060   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Symptomatic relief of chronic, severe spasticity 5 Year 12 Year Oral 500 micrograms/kg o.d.
2 Malignant hyperthermia 1 Month 18 Year IV 2 3 mg/kg Injection
3 Symptomatic relief of chronic, severe spasticity 12 Year 18 Year Oral 25 mg o.d.

Ref :- Book : Martindale    Page : 2060   Edition : 37,
►  Side Effect : drowsiness, Dizziness, fatigue, weakness, diarrhea, nausea, vomiting, anorexia, constipation, abdominal cramp, gastrointestinal bleeding, tachycardia, dyspnoea, Rashes, pruritus, chill, fever, myalgia, Nervousness, insomnia, Confusion, visual disturbances, mental depression, dysphagia, speech disturbances, seizure, haematuria, Crystalluria, urinary frequency, urinary retention, hepatotoxicity, headache, unstable blood pressure,
Ref :-   Book : Martindale    Page : 2059-2060   Edition : 37, Martindale    Page : 2059-2060    Edition : 37,

►  Drug Interaction : Drug interaction of Dantrolene Sodium is with CNS depressant, Alcohol,  Oestrogen,
Ref :-   Book : Martindale    Page : 2060   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The CNS effects of dantrolene sodium may be enhanced by alcohol or other CNS depressants. Use with other potentially hepatotoxic drugs such as oestrogens may possibly increase the risk of liver damage and should be avoided.,
Ref :-   Book : Martindale    Page : 2060   Edition : 37,


►  Contraindication : Active liver disease, acute muscle spasm, Dantrolene sodium should be used with caution in patients with cardiac or pulmonary disorders,
Ref :-   Book : Martindale    Page : 2060   Edition : 37,
  ►  Mechanism of Action :   Dantrolene sodium is a muscle relaxant with a direct action on skeletal muscle. It uncouples muscular contraction from excitation, probably by interfering with the release of calcium from the sarcoplasmic reticulum.,
Ref :-   Book : Martindale    Page : 2060   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Kava with Another pathway,

  ►  Pathway with its reference as follows :-
  • muscle relaxant effect . --- (airney, S., Clough, A., Maruff, P., Collie, A., Currie, B., & Currie, J. (2003). Saccade and Cognitive Function in Chronic Kava Users. Neuropsychopharmacology, 28(2), 389-396. )

  •   ►  URL -- ,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- MAGNESIUM with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 2060   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   9 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 2260   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,