Dapsone is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 284   Edition : 38,

  ►   Brandname : Acnesone,Aczone

  ►  Strength : Tablet with 25  mg, Tablet with 100  mg, Gel with 5  %, Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 848   Edition : 12, Martindale    Page : 281   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical, IM,
Reference :-   Book : Martindale    Page : 281   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Multibacillary leprosy Oral 100 mg Tablet Dose: Given with rifampicin 600 mg and clofazimine 300 mg are both given once a month
2 Multibacillary leprosy Oral 100 mg Tablet Dose: Given with clofazimine 50 mg both daily for 12 months
3 Multibacillary leprosy Oral 50 mg Tablet Dose: For adults weighing less than 35 kg: Given daily with reduced doses of rifampicin
4 Multibacillary leprosy Oral 1 2 mg/kg Tablet Dose: For adults weighing less than 35 kg: Given daily with reduced doses of rifampicin,
5 Paucibacillary leprosy Oral 100 mg Tablet Dose: rifampicin 600 mg once a month and dapsone given daily; both are given for 6 months
6 Pneumocystis pneumonia Oral 50 mg Tablet Dose: Dapsone given daily with pyrimethamine 50 mg once weekly
7 Pneumocystis pneumonia Oral 100 mg Tablet Dose: Plus pyrimethamine 50 mg both given twice weekly
8 Pneumocystis pneumonia Oral 200 mg Tablet Dose: Plus pyrimethamine 75 mg both given once weekly
9 Dermatitis herpetiformis Oral 50 mg Tablet Dose: Given daily gradually increased to 300 mg daily, or more if required
10 Acne Topical 5 % Gel b.d.

Ref :-  Book : Martindale    Page : 281-282   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Multibacillary leprosy 10 Year 14 Year Oral 50 mg Tablet
2 Multibacillary leprosy 10 Year 14 Year Oral 50 mg Tablet
3 Paucibacillary leprosy Oral 50 mg Tablet
4 Pneumocystis pneumonia 1 Month Oral 2 mg/kg Tablet
5 Pneumocystis pneumonia 1 Month Oral 4 mg/kg Tablet

Ref :- Book : Martindale    Page : 281   Edition : 38,
Precaution :- If a Patient is using 'Dapsone' drug in  autoimmune hemolytic anemia  disease, then Please Avoid .

Precaution :- If a Patient is using 'Dapsone' drug in  thallasemia  disease, then Please Use with caution .

►  Side Effect : haemolysis, methemoglobinemia, Rashes, pruritus, peripheral neuropathy, nausea, vomiting, anorexia, headache, hepatitis, insomnia, Psychosis, tachycardia, ,
Ref :-   Book : Martindale    Page : 282   Edition : 38,

►  Drug Interaction : Drug interaction of Dapsone is with Probenecid , Trimethoprim , Rifampicin , Clofazimine ,
Ref :-   Book : Martindale    Page : 283   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Serum concentrations of dapsone are increased, with a consequent increased risk of adverse effects, when given with probenecid, probably as a result of reduced renal excretion of dapsone. Increased dapsone and trimethoprim concentrations have also been reported in patients receiving both drugs, who may similarly be at greater risk of dapsone toxicity. Rifampicin reduces serum concentrations of dapsone to a level that may compromise efficacy in infections other than leprosy. Dapsone may reduce the anti-inflammatory effects of clofazimine.,
Ref :-   Book : Martindale    Page : 283   Edition : 38,


►  Contraindication : severe anaemia, sulfone allergy, Pregnancy,
Ref :-   Book : Martindale    Page : 283   Edition : 38, Martindale    Page : 283   Edition : 37,
  ►  Mechanism of Action :   Dapsone is a structural analog of para-aminobenzoic acid (PABA) and a competitive inhibitor of dihydropteroate synthase (folP1/P2) in the folate pathway. The effect on this evolutionarily conserved pathway also explains why dapsone is a broad-spectrum agent with antibacterial, anti-protozoal, and antifungal effects. The anti-inflammatory effects of dapsone occur via inhibition of tissue damage by neutrophils. First, dapsone inhibits neutrophil myeloperoxidase activity and respiratory burst. Second, it inhibits activity of neutrophil lysosomal enzymes. Third, it may also act as a free radical scavenger, counteracting the effect of free radicals generated by neutrophils. Fourth, dapsone may also inhibit migration of neutrophils to inflammatory lesions.,
Ref :-   Book : Goodman    Page : 1563   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- chaulmoogea oil with Another pathway,

  ►  Pathway with its reference as follows :-
  • Hydrocarpic and chaulmoogric Acid have antiliprotic effect --- (Kokate, c. & Purohit, A. (2016). pharmacognosy. nirali prakashan. )

  •   ►  URL -- https://www.sapnaonline.com/books/pharmacognosy-ck-kokate-8196396155-9788196396152,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- PROBIOTICS with It helps prevent antibiotic induced diarrhea ., VITAMIN E with Vitamin E therapy offered some protection against dapsone -induced hemolysis ,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 284   Edition : 38,


    ►    Plasma Half-life :   Min value :-   10 hours,    Max value :-   50 hours,
    Ref :-   Book : Martindale    Page : 284   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   8 hours,
    Ref :-   Book : Martindale    Page : 284   Edition : 38,