Daptomycin is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 282   Edition : 37,

  ►   Brandname : Cubicin

  ►  Strength : Injection with 0.25 or 0.5 g  gm,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 808   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV infusion, IV injection,
Reference :-   Book : Martindale    Page : 287   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Skin and soft-tissue infections IV infusion 4 mg/kg Injection o.d. Dose: Given over 30 minutes daily for 7 to 14 days
2 Skin and soft-tissue infections IV 4 mg/kg Injection o.d. Dose: Given over 2 minutes daily for 7 to 14 days
3 Bacteraemia IV 6 mg/kg Injection o.d. Dose: Given for 2 to 6 weeks.
4 Use actual body BW Example: 4-12 mg/kg of Actual BW IV q 24h. Ref: The Sanford Guide To Antimicrobial Therapy, pg 231, ed 47.

Ref :-  Book : Martindale    Page : 287   Edition : 37,    Page :    Edition : ,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : nausea, vomiting, constipation, diarrhoea, dyspepsia, headache, insomnia, Dizziness, fever, injection-site reactions, Rashes, pruritus, abnormal liver fuction tests, jaundice, hypertension, hypotension, renal failure, dyspnoea, anaemia, muscle pain, weakness, myositis, myopathy, ,
Ref :-   Book : Martindale    Page : 286   Edition : 37,

►  Drug Interaction : Drug interaction of Daptomycin is with Statins, Fibrates, , NSAIDS, ,  NA

  ►    Mechanism of Drug Drug Interaction :  There may be an increased risk of myopathy if daptomycin is given with other drugs also known to have this adverse effect, such as statins, fibrates, and ciclosporin. Daptomycin is mainly excreted by renal filtration and caution is advised if given with drugs that reduced renal filtration, such as NSAIDs and selective inhibitors of cyclo-oxygenase-2, since plasma concentrations of daptomycin may be increased. ,
Ref :-   Book : Martindale    Page : 287   Edition : 37,


►  Contraindication : Myopathy, renal impairment, peripheral neuropathy,
Ref :-   Book : Martindale    Page : 286   Edition : 37,
  ►  Mechanism of Action :   Daptomycin is a lipopeptide antibacterial. Daptomycin disrupt the bacterial cell membrane potential by binding to the cell membranes in a calcium-dependent process, but without entering the cytoplasm, thus inhibiting the synthesis of protein, DNA and RNA.,
Ref :-   Book : Martindale    Page : 287   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal, Faecal,
Ref :-   Book : Martindale    Page : 287   Edition : 37,


►    Plasma Half-life :
  Min value :-   8 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 287   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   0.5 hours,    Max value :-   0.8 hours,
Ref :-   Book : Martindale    Page : 287   Edition : 37,