Darunavir is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 959   Edition : 37,

  ►   Brandname : Prezista

  ►  Strength : Tablet with 300  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 888   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 888   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Antiretroviral Oral 600 mg Tablet b.d. Dose: Given with ritonavir 100 mg. Treatment-naïve: 800 mg qd with ritonavir 100 mg qd. Tablets can be dissolved in water

Ref :-  Book : Basic & Clinical pharmacology    Page : 870   Edition : 12,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 HIV infection and AIDS 20 to less than 30 kg Oral 375 mg Tablet b.d.
2 HIV infection and AIDS 30 to less than 40 kg Oral 450 mg Tablet b.d.
3 HIV infection and AIDS 40 kg and over Oral 600 mg Tablet b.d.

Ref :- Book : Martindale    Page : 959   Edition : 37,
►  Side Effect : abdominal pain, diarrhea, nausea, vomiting, nasopharyngitis, hypertriglyceridaemia, asthenia, Dizziness, fatigue, headache, Abnormal liver and pancreatic function tests, Skin rashes, insomnia, folliculitis, myocardial infarction, osteoporosis, polyuria, Somnolence, tachycardia, transient ischaemic attacks, vertigo, osteopenia,
Ref :-   Book : Martindale    Page : 959   Edition : 37,

►  Drug Interaction : Drug interaction of Darunavir is with alpha1 - adrenoceptor antagonist, Antiarrhythmics, antihistamines, ergot derivatives, Gastrointestinal drug/ Prokinetic , Antipsychotic , Sedatives- hypnotics , Statins, ,  Alfuzosin , Amiodarone , Bepridil, Quinidine , Astemizole, Terfenadine, dihydroergotamine, Ergometrine , Ergotamine, Methylergometrine, Cisapride , Pimozide , Midazolam , Triazolam , Simvastatin , Lovastatin ,
Ref :-   Book : Martindale    Page : 959   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Darunavir inhibits, and is extensively metabolised by the cytochrome P450 isoenzyme CYP3A4. It may affect the clearance of other drugs metabolised by this enzyme, potentially resulting in increased plasma concentrations and toxicity. Darunavir is contra-indicated with drugs that are highly dependent on CYP3A4 for clearance and for which elevated plasma concentrations are associated with serious or life-threatening events. These drugs include the alpha1 - adrenoceptor antagonist alfuzosin, antiarrhythmics (amiodarone, bepridil, quinidine, and systemic lidocaine), antihistamines (astemizole and terfenadine), ergot derivatives (dihydroergotamine, ergometrine, ergotamine, methylergometrine), gastrointestinal prokinetics (cisapride), antipsychotics (pimozide), sedatives and hypnotics (midazolam and triazolam), and statins (simvastatin and lovastatin). St john’s wort decrease the concentration of darunavir.,
Ref :-   Book : Martindale    Page : 959   Edition : 37,


►  Contraindication : Severe hepatic impairment, Darunavir contains a sulfonamide moiety and should be used with caution in patients with known sulfonamide sulfonamide hypersensitivity, although its cross-sensitivity potential with sulfonamide drugs is unknown, Caution is advised in treating patients with haemophilia A and B as reports of spontaneous bleeding have been associated with the use of HIV-protease inhibitors, An association with erythema multiforme and Stevens-Johnson syndrome has been reported and treatment should be stopped in patients who develop skin rashes,
Ref :-   Book : Martindale    Page : 959   Edition : 37,
  ►  Mechanism of Action :   Darunavir is a selective inhibitor of HIV-1 protease. It interferes with the formation of essential viral proteins making them incapable of infecting other cells. ,
Ref :-   Book : Martindale    Page : 959   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- African potato with Another pathway,

  ►  Pathway with its reference as follows :-
  • Ant-HIV effect . --- (Peltzer, K., Friend-du Preez, N., Ramlagan, S., Fomundam, H., Anderson, J., & Chanetsa, L. (2011). Antiretrovirals and the use of traditional, complementary and alternative medicine by HIV patients in KwaZulu-Natal, South Africa: a longitudinal study. African Journal Of Traditional, Complementary And Alternative Medicines, 8(4). http://dx.doi.org/10.4314/ajtcam.v8i4.1 )

  •   ►  URL -- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218455/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 959   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   15 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 959   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   2.5 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 959   Edition : 37,