Dasatinib is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 775   Edition : 37,

  ►   Brandname : Sprycel

  ►  Strength : Tablet with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 775   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 775   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Chronic myeloid leukemia Oral 100 mg Tablet o.d.

Ref :-  Book : Martindale    Page : 775   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : GI distress, diarrhea, nausea, vomiting, fluid retention, gastrointestinal disturbance, gastrointestinal bleeding, pleural effusion, pericardial effusion, pulmonary oedema, ascites, severe CNS haemorrhages, Myelosuppression, headache, pyrexia, musculoskeletal pain, fatigue, Skin rashes, dyspnoea, Cough, Dizziness, chest pain, neuropathy, chill, chills, pruritus, cardiac failure, arrhythmia, Arrhythmias, prolong QT interval ,
Ref :-   Book : Martindale    Page : 775   Edition : 37,

►  Drug Interaction : Drug interaction of Dasatinib is with , Azole Antifungal, Macrolide, Antibacterials , HIV- protease inhibitors, , Antacid , Proton pump inhibitor , Histamine H2-receptor antagonist,  Nefazodone, Carbamazapine , Dexamethasone , Phenobarbital , Phenytoin , Rifampicin , Famotidine , Omeprazole ,
Ref :-   Book : Martindale    Page : 775   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Dasatinib is metabolised by the cytochrome P450 isoenzyme CYP3A4, and drugs that inhibit this enzyme, such as azole antifungals, macrolide antibacterials, HIV-protease inhibitors, and nefazodone may increase blood concentrations of dasatinib. Equally, inducers of CYP3A4 (such as carbamazepine, dexamethasone, phenobarbital, phenytoin, and rifampicin) may reduce blood concentrations of dasatinib. Since St John’s wort may decrease decrease dasatinib concentrations unpredictably, these drugs should not be given together. Dasatinib is a substrate of the cytochrome P450 isoenzyme CYP3A4, and may alter blood concentrations of other drugs that are substrates of this enzyme. Since the solubility of dasatinib is dependent on pH, use with antacids should be avoided. If antacid therapy is needed, it should be given at least 2 hours before or 2 hours after the dose of dasatinib. Similarly, histamine H2-receptor antagonists or proton pump inhibitors such as famotidine or omeprazole should not be given with dasatinib as long-term suppression of gastric acid secretion is likely to reduce dasatinib exposure.,
Ref :-   Book : Martindale    Page : 775   Edition : 37,


►  Contraindication : Dasatinib has the potential to prolong the QT interval, and should be given with caution to patients at risk of this, such as those with hypokalaemia, hypomagnesaemia, or those on antiarrhythmic therapy, or receiving cumulative high doses of anthracycline,
Ref :-   Book : Martindale    Page : 775   Edition : 37,
  ►  Mechanism of Action :   Dasatinib is an inhibitor of several tyrosine kinases including BCR-ABL (Philadelphia chromososme) and SRC family tyrosine kinases.,
Ref :-   Book : Martindale    Page : 775   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Vinca with Another pathway,

  ►  Pathway with its reference as follows :-
  • Anticancer effect . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan.,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- BLACK CHOSH with GI upset,

      ►  Reference :-
  • Posadzki, P., Watson, L., & Ernst, E. (2012). Herb-drug interactions: an overview of systematic reviews. British Journal Of Clinical Pharmacology, no-no. http://dx.doi.org/10.1111/j.1365-2125.2012.04350.x

  •   ►  URL -- http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04350.x/full,

    ►   Route of Elimination :   Renal, Faecal,
    Ref :-   Book : Martindale    Page : 775   Edition : 37,


    ►    Plasma Half-life :   Min value :-   5 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 775   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   0.5 hours,    Max value :-   6 hours,
    Ref :-   Book : Martindale    Page : 775   Edition : 37,