Daunorubicin (Daunomycin) is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 777   Edition : 37,

  ►   Brandname : Cerubidine,Daunotec,Norubin,DaunoXome

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 777   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 777   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Acute lymphoblastic leukaemia IV 45 mg/m2 Injection Dose: Given daily.
2 Kaposi’s sarcoma IV 40 mg/m2 Injection
3 Myeloid leukaemia IV 45 mg/m2 Injection Dose: Given daily.
4 Acute leukaemias IV 40 60 mg/m2 Injection Dose: Given on alternate days for a course of upto 3 injections.

Ref :-  Book : Martindale    Page : 777   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Acute lymphoblastic leukaemia IV 25 mg/m2 Injection QWK

Ref :- Book : Martindale    Page : 777   Edition : 37,
►  Side Effect : gastrointestinal disturbance, mucositis, alopecia, hypersensitivity reactions, hyperuricaemia, conjunctivitis, Lacrimation, Urticaria, Onycholysis, renal damage, Hepatic damage, Urticarial rashes, Transient increases in liver enzymes, Hyperpigmentation of the oral mucosa and/ or nails,
Ref :-   Book : Martindale    Page : 776-780   Edition : 37,

►  Drug Interaction : Drug interaction of Daunorubicin (Daunomycin) is with , Live Vaccines,  Doxorubicin, Cyclophosphamide , Stavudine, Lincomycin,
Ref :-   Book : Martindale    Page : 698, 781   Edition : 37, Martindale    Page : 698-781   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The cumulative dose of Daunorubicin should be reduced in patients who have received other cardiotoxic drugs such as doxorubicin or cyclophosphamide. Daunorubicin is reported to inhibit the intracellular activation of stavudine and hence its antiviral effect. Antineoplastics have the potential to interfere with the absorption of drugs given orally. Antineoplastics that have an immunosuppressant effect may reduce the response to vaccines, possibility of generalised infection with live vaccines. Use with live vaccines should generally be avoided. Many antineoplastics are inhibitors of certain isoenzymes of cytochrome P450) and some antineoplastics are also metabolised by these enzymes, and in consequence the possibility of interactions between antineoplastics, or between antineoplastics and other medication, cannot be discounted ,
Ref :-   Book : Martindale    Page : 698, 781   Edition : 37,


►  Contraindication : hepatic impairment, renal impairment,
Ref :-   Book : Martindale    Page : 776   Edition : 37,
  ►  Mechanism of Action :   It is thought to have multiple modes of action including intercalation of DNA leading to an inhibition of DNA and RNA synthesis, inhibition of topoisomerase II, free radical formation, and alterations in cell membranes. ,
Ref :-   Book : Martindale    Page : 776-782   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Vinca with Another pathway,

  ►  Pathway with its reference as follows :-
  • Anticancer effect . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- BLACK CHOSH with GI upset,

      ►  Reference :-
  • Posadzki, P., Watson, L., & Ernst, E. (2012). Herb-drug interactions: an overview of systematic reviews. British Journal Of Clinical Pharmacology, no-no. http://dx.doi.org/10.1111/j.1365-2125.2012.04350.x

  •   ►  URL -- http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04350.x/full,

    ►   Route of Elimination :   Biliary, Renal,
    Ref :-   Book : Martindale    Page : 776   Edition : 37,


    ►    Plasma Half-life :   Min value :-   18.5 hours,    Max value :-   26.7 hours,
    Ref :-   Book : Martindale    Page : 776   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA