Deferoxamine is a Medicine belongs to Chelators Antidotes and Antagonists group whose information about Brand can be referenced from   Book : Martindale    Page : 1582   Edition : 37,

  ►   Brandname : Desferal

  ►  Strength : Injection with 500  mg, Injection with 2000  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 598   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : SC, IV, IM, Oral, Intraperitoneal,
Reference :-   Book : Martindale    Page : 1580-1581   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Chronic iron overload SC infusion 500 mg Injection
2 Chronic iron overload IM 0.5 1 gm Injection
3 Blood transfusion IV infusion up to 2 gm Injection Dose: Given by intravenous infusion for each unit of blood transfused, at a rate not more than 15 mg/kg per hour.
4 Acute iron poisoning i.v/i.m 500 mg Injection Dose: Given intravenously, at a rate not exceeding 125 mg/ hour, or intramuscularly, every 4 hours for 2 doses, then every 4 to 12 hours according to response to a maximum of 6 g in 24 hours.
5 Aluminium overload Slow IV infusion 5 mg/kg Injection QWK Dose: For Haemodialysis or haemofiltration
6 Chronic iron overload IV infusion 500 mg Injection

Ref :-  Book : Martindale    Page : 1581   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Chronic iron overload 30 mg/kg Injection
2 Chronic iron overload under 3 Year 40 mg/kg Injection
3 Acute iron poisoning IM 1 gm Injection

Ref :- Book : Martindale    Page : 1581   Edition : 37,
►  Side Effect : flushing, Urticaria, hypotension, shock, local pain, pruritus, erythema, swelling, gastrointestinal disorders, dysuria, fever, allergic skin rashes, tachycardia, cardiac arrhythmia, convulsion, leg cramps, visual disturbances, Hearing loss, cataract formation, Retard growth in very young children, retinal changes,
Ref :-   Book : Martindale    Page : 1579   Edition : 37,

►  Drug Interaction : Drug interaction of Deferoxamine is with Vitamin C/Ascorbic Acid, Phenothiazine,
Ref :-   Book : Martindale    Page : 1580   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Deferoxamine is usually given parenterally and thus drug interactions due to chelation with oral metal ions are not a problem...Ascorbic acid is often given in addition to desferrioxamine to patients with iron overload to achieve better iron excretion.,
Ref :-   Book : Martindale    Page : 1580   Edition : 37,


►  Contraindication : renal insufficiency, Anuria, Pregnancy,
Ref :-   Book : Goodman    Page : 1876   Edition : 12,
  ►  Mechanism of Action :   Deferoxamine is a chelator that has a high affinity for ferric iron it forms a stable water-soluble iron-complex that is readily excreted in the urine and in bile Desferrioxamine appears to remove both free iron and bound iron from haemosiderin and ferritin but not from haemoglobin, transferrin, or cytochromes.,
Ref :-   Book : Martindale    Page : 1580   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Curcumin with same pathway, steamed charcoal with Another pathway,

  ►  Pathway with its reference as follows :-
  • binding free iron in the bloodstream and enhancing its elimination in the urine --- (Hatcher, H., Singh, R., Torti, F., & Torti, S. (2009). Synthetic and natural iron chelators: therapeutic potential and clinical use. Future Medicinal Chemistry, 1(9), 1643-1670. )
  • Activated Charcoal --- (Matine, A. (1861). The Eclectic Repertory And Analytical Review Medical Philosophical (6th ed.). Thomas Dobson. )

  •   ►  URL -- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821171/, https://books.google.co.in/books?id=xi1jDAAAQBAJ&pg=PA66&dq=charcoal+having+antidotes&hl=en&sa=X&redir_esc=y#v=onepage&q=charcoal%20having%20antidotes&f=false,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- IRON with People treated with deferoxamine for dangerously high levels of iron should not take iron supplements .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Renal, Biliary,
    Ref :-   Book : Martindale    Page : 1580   Edition : 37,


    ►    Plasma Half-life :   Min value :-   initial half life 1 hours and a terminal half life 6 hours ,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1547   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA