Demeclocycline is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 288   Edition : 37,

  ►   Brandname : Declomycin,Ledermycin

  ►  Strength : Tablet with 150  mg, Tablet with 300  mg, Capsule with   , Oral Suspension with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 819   Edition : 12, Martindale    Page : 288   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 288   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Infections Oral 600 mg Dose: Given daily in 2 or 4 divided doses.
2 Atypical Pneumonia Oral 900 mg Dose: Given daily in 3 divided doses
3 Hyponatremia Oral 900 1200 mg Dose: Given daily in divided doses.

Ref :-  Book : Martindale    Page : 288   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Antibacterial 12 Year and over Oral 600 mg
2 Antibacterial over 8 Year Oral 7 13 mg/kg

Ref :- Book : Martindale    Page : 288   Edition : 37,
►  Side Effect : Bulging fontanelle, temporary stunning of growth, hepatotoxicity, pseudotumor cerebri, photosensitivity, gastrointestinal disturbance, candial infection, discoloration of teeth, hypoplasia of teeth, rash,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 596   Edition : 3,

►  Drug Interaction : Drug interaction of Demeclocycline is with Antacid , , Diuretic Agents , Nephrotoxic drugs,  Iron , Methoxyflurane,
Ref :-   Book : Martindale    Page : 287,378   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Use of Demeclocycline with antacids, iron preparations, some foods such as milk and dairy products, may result in subtherapeutic serum concentrations. The nephrotoxic effects may be exacerbated by diuretics, methoxyflurane, or other potentially nephrotoxic drugs.,
Ref :-   Book : Martindale    Page : 287-378   Edition : 37,


►  Contraindication : renal impairment, Last half of pregnancy, Infancy, childhood up to 8 years of age,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 597   Edition : 3, Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 596   Edition : 3,
  ►  Mechanism of Action :   Demeclocycline is a tetracycline derivative. It interfere with protein synthesis by binding to bacterial ribosome and their selective action is due to higher uptake by bacterial than by human cells. They are bacteriostatic. Ref: Martindale pg no 288 ed 37.,
Ref :-   Book : Clinical Pharmacology    Page : 226   Edition : 9,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Garlic with Another pathway,

  ►  Pathway with its reference as follows :-
  • Alliin and Allicin have Antibiotic effect --- ( Duke, J. & Duke, J. (2002). Handbook of medicinal herbs. Boca Raton, FL: CRC Press )

  •   ►  URL -- https://books.google.co.in/books?id=8AJkBmPDRUUC&redir_esc=y,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Hepatic (Metabolism), Biliary,
    Ref :-   Book : Goodman    Page : 1524   Edition : 12,


    ►    Plasma Half-life :
      Min value :-   12 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 287   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   3 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 287   Edition : 37,