Desflurane is a Medicine belongs to General anaesthetics group whose information about Brand can be referenced from   Book : Martindale    Page : 1938   Edition : 37  

  ►   Brandname : Suprane
  ►  Strength : Volatile Liquid with 240 mL. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 446   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : inhalation
Reference :-   Book : Martindale    Page : 1938   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Anaesthesia inhalation Concentrations of 4 to 11% v/v have been used for induction and usually produce surgical anaesthesia in 2 to 4 minutes.
2 Anaesthesia inhalation Concentrations of 2 to 6% v/v with nitrous oxide or 2.5 to 8.5% v/v in oxygen or oxygen enriched air may be used to maintain anaesthesia.

Ref :-  Book : Martindale    Page : 1938   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Respiratory depression, Hypotension, Arrhythmia, Malignant hyperthermia, Nausea, Vomiting, Apnoea, Coughing, Increased salivation, Laryngospasm
Ref :-   Book : Martindale    Page : 1937   Edition : 37.  

►  Drug Interaction : Drug interaction of Desflurane is with Benzodiazepine , sympathomimetic , Sedatives, Opoids,  Atracurium , Adrenaline
Ref :-   Book : Martindale    Page : 1938   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  The effects of competitive neuromuscular blockers such as atracurium are enhanced by desflurane. Lower doses of desflurane are required in those receiving opoids, benzodiazepines or other sedatives. Care advised if adrenaline or other sympathomimetics are given to patients during desflurane anaesthesia.
Ref :-   Book : Martindale    Page : 1938   Edition : 37.  

►  Contraindication : Raised intracranial pressur, Susceptibility to malignant hyperthermia
Ref :-   Book : Martindale    Page : 1937   Edition : 37.   Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 260   Edition : 3.  
  ►  Mechanism of Action :   General anesthetics, mechanism of action remains unknown. In recent years this “unitary theory” of anesthetic action has been supplanted by a more complex picture of molecular targets located at multiple levels of the central nervous system (CNS). Anesthetics affect neurons at various cellular locations, but the primary focus has been on the synapse. A presynaptic action may alter the release of neurotransmitters, whereas a postsynaptic effect may change the frequency or amplitude of impulses exiting the synapse. At the organ level, the effect of anesthetics may result from strengthening inhibition or from diminishing excitation within the CNS. Studies on isolated spinal cord tissue have demonstrated that excitatory transmission is impaired more strongly by anesthetics than inhibitory effects are potentiated. Chloride channels (γ-aminobutyric acid-A [GABA A ] and glycine receptors) and potassium channels (K 2P , possibly K v , and K ATP channels) remain the primary inhibitory ion channels considered legitimate candidates of anesthetic action. Excitatory ion channel targets include those activated by acetylcholine (nicotinic and muscarinic receptors), by excitatory amino acids (amino-3-hydroxy-5-methyl- 4-isoxazol-propionic acid [AMPA], kainate, and N -methyl- D - aspartate [NMDA] receptors), or by serotonin (5-HT 2 and 5-HT 3 receptors).
Ref :-   Book : Basic & Clinical pharmacology    Page : 429, 430   Edition : 12.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Lungs
Ref :-   Book : Martindale    Page : 1938   Edition : 37.  

►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA