Desmopressin is a Medicine belongs to Endocrine drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 2390   Edition : 37,

  ►   Brandname : D-Void,DDAVP,DesmoMelt,Desmospray,Minirin,Stimate

  ►  Strength : Nasal solution with 0.1  mg/ml, Nasal solution with 1.5  mg/ml, Injection with 4  microgram/ml, Tablet with 0.1  mg, Tablet with 0.2  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 678   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, SC, IM, intranasal,
Reference :-   Book : Martindale    Page : 2387   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Cranial diabetes insipidus Oral 100 micrograms Tablet t.i.d.
2 Cranial diabetes insipidus sublingual 60 micrograms Tablet t.i.d. Dose: Given as sublingual lyophilisate preparation
3 Cranial diabetes insipidus intranasal 10 40 micrograms Solution Dose: Given daily as a single dose or in divided doses
4 Cranial diabetes insipidus s.c, i.v, i.m 1 4 micrograms Injection Dose: Given daily.
5 Diagnosis of diabetes insipidus intranasal 20 micrograms Solution
6 Diagnosis of diabetes insipidus s.c/ i.m 2 micrograms Injection
7 Testing of renal function intranasal 40 micrograms Solution Dose: Given as single dose.
8 Testing of renal function s.c/ i.m 2 micrograms Injection
9 Primary nocturnal enuresis Oral 200 400 micrograms Tablet h.s.
10 Nocturia intranasal 10 20 micrograms Solution h.s.
11 Haemophilia or type I von Willebrand’s disease Slow IV infusion 300 400 nanogram/kg Injection Dose: Given over 15 to 30 minutes, or by subcutaneous injection, just before surgery.
12 Haemophilia or type I von Willebrand’s disease intranasal 150 300 micrograms Solution Dose: Given 0.5 to 2 hours before surgery, (in patients weighing less than 50 kg
13 Testing of fibrinolytic response IV infusion 300 400 nanogram/kg Injection Dose: Given over 20 minutes.
14 Testing of fibrinolytic response intranasal 300 micrograms Solution Dose: Given 60 minutes before collecting the blood sample.
15 Testing of fibrinolytic response SC 300 nanogram/kg Injection
16 Post-dural puncture headache SC 4 mcg Injection
17 Post-dural puncture headache IM 4 mcg Injection

Ref :-  Book : Martindale    Page : 2388   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Diabetes insipidus intranasal 100 500 nanograms Solution
2 Diabetes insipidus 1 Month 2 Year intranasal 2.5 5 micrograms Solution o.d/b.d
3 Diabetes insipidus 2 Year 12 Year intranasal 5 20 micrograms Solution o.d/b.d
4 Diabetes insipidus 12 Year 18 Year intranasal 10 20 micrograms Solution o.d/b.d
5 Diabetes insipidus s.c/ i.m 100 nanograms Injection o.d.
6 Diabetes insipidus 1Month 12 Year s.c/ i.m 400 nanograms Injection o.d.
7 Diabetes insipidus 12 Year 18 Year s.c/ i.m 1 4 micrograms Injection o.d.
8 Test for suspected diabetes insipidus 1 Month 2 Year intranasal 5 10 micrograms Solution
9 Test for suspected diabetes insipidus 2 Year 12 Year intranasal 10 20 micrograms Solution
10 Test for suspected diabetes insipidus 12 Year 18 Year intranasal 20 micrograms Solution
11 Test for suspected diabetes insipidus 1 Month 2 Year s.c/ i.m 400 nanograms Injection
12 Test for suspected diabetes insipidus 2 Year 12 Year s.c/ i.m 0.5 1 micrograms Injection
13 Test for suspected diabetes insipidus 12 Year 18 Year s.c/ i.m 1 2 micrograms Injection
14 Primary nocturnal enuresis 5 Year 18 Year Oral 200 micrograms Tablet h.s.
15 Primary nocturnal enuresis 5 Year 18 Year sublingual 120 micrograms Tablet h.s.
16 Mild to moderate haemophilia or von Willebrand’s disease 1 Month 18 Year s.c or i.v 300 nanogram/kg Injection
17 Mild to moderate haemophilia or von Willebrand’s disease 1 Year 18 Year intranasal 4 micrograms/kg Solution
18 Testing of fibrinolytic response 2 Year 18 Year s.c or i.v 300 nanogram/kg Injection
19 Test of antidiuretic hormone secretion (congenital deficiency suspected) 1 Month 2 Year intranasal 100 500 nanograms
20 Test of antidiuretic hormone secretion (congenital deficiency not suspected) 1 Month 2 Year intranasal 1 5 micrograms Solution
21 Diabetes insipidus Oral 1 4 micrograms b.d/t.i.d
22 Diabetes insipidus 1 Month 2 Year Oral 10 micrograms b.d/t.i.d
23 Diabetes insipidus 2 Year 12 Year Oral 50 micrograms b.d/t.i.d
24 Diabetes insipidus 12 Year 18 Year Oral 100 micrograms Tablet b.d/t.i.d
25 Diabetes insipidus 2 Year 18 Year sublingual 60 micrograms Tablet t.i.d.
26 Testing of renal function 1 Month 1 Year intranasal 10 micrograms Solution
27 Testing of renal function 1 Year 15 Year intranasal 20 micrograms Solution
28 Testing of renal function 15 Year 18 Year intranasal 40 micrograms Solution
29 Testing of renal function 1 Month 1 Year s.c/ i.m 400 nanograms Injection
30 Testing of renal function 1 Year 18 Year s.c/ i.m 2 mcg Injection

Ref :- Book : Martindale    Page : 2388-2389   Edition : 37,
►  Side Effect : headache, nausea, mild abdominal cramps, pain and swelling at the site of injection, hypotension, tachycardia, facial flushing, cerebral or coronary thrombosis,
Ref :-   Book : Martindale    Page : 2387   Edition : 37,

►  Drug Interaction : Drug interaction of Desmopressin is with Tricyclic antidepressant , Alcohol, Ganglion Blockers, ,  Chlorpropamide , Clofibrate, Carbamazapine , Fludrocortisone , Urea , Heparin , Demeclocycline , Noradrenaline/Norepinephrine , Indomethacin ,
Ref :-   Book : Martindale    Page : 2651, 2388   Edition : 37, Martindale    Page : 2651-2388   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The antidiuretic effects of vasopressins might be expected to be enhanced in some patients receiving chlorpropamide, clofibrate, carbamazepine, fludrocortisone, urea, or tricyclic antidepressants. Lithium, heparin, demeclocycline, noradrenaline, and alcohol may decrease the antidiuretic effect. Ganglion-blocking drugs may increase sensitivity to the pressor effects of vasopressins. Indometacin, may enhance the antidiuretic effect of desmopressin.,
Ref :-   Book : Martindale    Page : 2388,2651   Edition : 37,


►  Contraindication : It should not be given to patients with type IIB von Willebrand’s disease, in whom the release of clotting factors may lead to platelet aggregation and thrombocytopenia., renal impairment,
Ref :-   Book : Martindale    Page : 2387   Edition : 37,
  ►  Mechanism of Action :   Desmopressin is a synthetic analogue of vasopressin. It has greater antidiuretic activity and a more prolonged action than vasopressin or lypressin. It also stimulates factor VIII and plasminogen activator activity in the blood, but has little pressor activity.,
Ref :-   Book : Martindale    Page : 2388   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Licorice with Another pathway,

  ►  Pathway with its reference as follows :-
  • Triterpene saponins, flavonoids, Isoflavonoids have Antidiuretic property. --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :
      Min value :-   8 minutes,    Max value :-   75 minutes for two phase respectively,
    Ref :-   Book : Martindale    Page : 2388   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA