Dexamethasone is a Medicine belongs to Corticosteroid group whose information about Brand can be referenced from   Book : Martindale    Page : 1667   Edition : 37,

  ►   Brandname : Decdan,Dexacip,Dexsol,Dalalone,Maxidex,Decadron

  ►  Strength : Tablet with 0.25  mg, Tablet with 0.5  mg, Tablet with 0.75  mg, Tablet with 1  mg, Tablet with 1.5  mg, Tablet with 2  mg, Tablet with 4  mg, Tablet with 6  mg, Elixir with 0.5/5  mg/ml, Solution with 0.5/5  mg/ml, Solution with 1  mg/ml, Injection with 4  mg/ml, Injection with 10  mg/ml, Injection with 20  mg/ml, Injection with 24  mg/ml, Injection with 8  mg/ml, Injection with 16  mg/ml, Eye Drop with   , Suspension with   , Ear spray with   , Cream with 0.02 -0.1  %, Ointment with 0.02-0.1  %, Solution with 0.02-0.1  %, Solution with 0.05-0.1  %, Ointment with 0.05-0.1  %, Lotion with 0.02-0.1  %, Nasal Spray with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 712   Edition : 12, Martindale    Page : 1667   Edition : 37, Martindale    Page : 1665   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical, IV, IM, intralesional, intra-articular injection, inhalation,
Reference :-   Book : Martindale    Page : 1665   Edition : 37, Basic & Clinical pharmacology    Page : 712   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Severe shock IV 2 6 mg/kg Injection Dose: Given slowly over a minimum period of several minutes.
2 Cerebral oedema due to malignancy IV 10 mg Injection Dose: followed by 4 mg i.m every 6 hours until the symptoms of odema subside.
3 2 6 mg Injection For soft-tissue injection. For intraarticular injection doses equivalent to 0.8 to 4 mg of dexamethasone phosphate are used depending upon the size of the joint.
4 Eye and ear disorder Topical 0.05 0.1 % eye or ear drops
5 Skin disorders Topical 0.02 0.1 % Ointment
6 Skin disorders Topical 0.02 0.1 % Cream
7 Skin disorders Topical 0.02 0.1 % Lotion
8 Diagnosis of Cushings' syndrome Oral 0.5 10 mg Dose: Given daily.

Ref :-  Book : Martindale    Page : 1665   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Bronchopulmonary dysplasia 0.25 mg/kg/day
2 Chemotheraphy induced vomiting Oral 0.1 mg/kg t.i.d.
3 0.5 mg/kg
4 Nausea Oral 0.1 mg/kg/dose t.i.d.
5 Croup Oral 0.6 mg/kg
6 Meningitis 0.6 mg/kg/day
7 Acute bacterial meningitis caused by H. influenzae type b IV 0.15 mg/kg Injection
8 Nausea IV 0.1 mg/kg/dose Injection t.i.d.

Ref :- Book : Nelson's textbook of Pediatrics    Page : 589   Edition : 19, Nelson's textbook of Pediatrics    Page : 1244   Edition : 19, Nelson's textbook of Pediatrics    Page : 1448   Edition : 19, Nelson's textbook of Pediatrics    Page : 155   Edition : 19, Nelson's textbook of Pediatrics    Page : 942   Edition : 19, Nelson's textbook of Pediatrics    Page : 2094   Edition : 19,
►  Side Effect : hypertension, Hyperglycaemia, hypercalcaemia, osteoporosis, growth retardation in children, muscle atrophy, impaired wound healing, fluid retention, oropharyngeal candidiasis, dysphonia, skin atrophy, ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 503   Edition : 3,    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Dexamethasone is with Barbiturates , Oral Contraceptive, Thiazide Diuretics , Beta 2 Agonist, NSAIDS, Antidiabetic , Antihypertensive Agents , Salicylates, Potassium-depleting diuretics, ,  Phenytoin , Carbamazapine , Primidone , Rifampicin , Ritonavir, Furosemide , Amphotericin B , Xanthinol nicotinate ,
Ref :-   Book : Martindale    Page : 1632-1665   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  dexamethasone may decrease or increase plasma concentrations of phenytoin. Concurrent use of barbiturates, carbamazepine, phenytoin, primidone, or rifampicin may enhance the metabolism and reduce the effects of systemic corticosteroids. Conversely oral contraceptives or ritonavir may increase plasma concentrations of corticosteroids. Use of corticosteroids with potassium-depleting diuretics, such as thiazides or furosemide, may cause excessive potassium loss. There is also an increased risk of hypokalaemia with concurrent amphotericin B or bronchodilator therapy with xanthines or beta2 agonists. There may be an increased incidence of gastrointestinal bleeding and ulceration when corticosteroids are given with NSAIDs. Response to anticoagulants may be altered by corticosteroids and requirements of antidiabetic drugs and antihypertensives may be increased. Corticosteroids may decrease serum concentrations of salicylates and may decrease the effect of anticholinesterases in myasthenia gravis.,
Ref :-   Book : Martindale    Page : 1632-1665   Edition : 37,


►  Contraindication : Systemic fungal infection,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 503   Edition : 3,
  ►  Mechanism of Action :   Dexamethasone bind to specific receptor proteins in target tissues to regulate the expression of corticosteroid-responsive genes, thereby changing the levels and array of proteins synthesized by the various target tissues. As a consequence of the time required to modulate gene expression and protein synthesis, most effects of corticosteroids are not immediate but become apparent after several hours. This fact is of clinical significance because a delay generally is seen before beneficial effects of corticosteroid therapy become manifest. ,
Ref :-   Book : Goodman    Page : 1216,1217   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Aloe vera with Another pathway,

  ►  Pathway with its reference as follows :-
  • anti-inflammatory effect . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NONI with Decreased gastric transit time‡, increased risk of hyperkalemia,,

      ►  Reference :-
  • Posadzki, P., Watson, L., & Ernst, E. (2012). Herb-drug interactions: an overview of systematic reviews. British Journal Of Clinical Pharmacology, no-no. http://dx.doi.org/10.1111/j.1365-2125.2012.04350.x

  •   ►  URL -- http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04350.x/full,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1665   Edition : 37,


    ►    Plasma Half-life :   Min value :-   190 minutes,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1165   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA