Dexrazoxane is a Medicine belongs to Chelators Antidotes and Antagonists group whose information about Brand can be referenced from   Book : Martindale    Page : 1548   Edition : 38,

  ►   Brandname : Cardioxane,Savene,Totect,Zinecard

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1548   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 1548   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Antineoplastic IV Injection For instance 500 mg/m2 of dexrazoxane is given for every 50 mg/m2 of doxorubicin

Ref :-  Book : Martindale    Page : 1548   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : bone marrow depression, Pain, leucopenia, thrombocytopenia, anaemia, gastrointestinal disorders, neurotoxicity, alopecia, fever, pain at the injection site, thromboembolism, Transient increase in serum concentration of triglycerides, transient decrease in serum calcium concentration , Liver dysfunction, bone marrow aplasia, increase urinary clearance of iron and zinc,
Ref :-   Book : Martindale    Page : 1548   Edition : 38,

►  Drug Interaction : Drug interaction of Dexrazoxane is with Antineoplastic ,  NA

  ►    Mechanism of Drug Drug Interaction :  Dexrazoxane may reduce the efficacy of some antineoplastic regimens,
Ref :-   Book : Martindale    Page : 1583   Edition : 37,


►  Contraindication : , Liver dysfunction, Clearance of dexrazoxane and its active metabolites may be reduced in patients with renal impairment,
Ref :-   Book :    Page :    Edition : , Martindale    Page : 1583   Edition : 37,
  ►  Mechanism of Action :   It chelates iron within the cells and appears to prevent the formation of the anthracycline- iron complex that is thought to be responsible for cardiotoxicity,
Ref :-   Book : Martindale    Page : 1583   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 1548   Edition : 38,


►    Plasma Half-life :
  Min value :-   2 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1548   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : ,