Dextran is a Medicine belongs to Plasma Expanders group whose information about Brand can be referenced from   Book : Martindale    Page : 1168   Edition : 37  

  ►   Brandname : Gentran 70, RescueFlow, Hyskon, Macrodex

  ►  Strength : Injection with 6 %. 

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1168   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV
Reference :-   Book : Martindale    Page : 1168   Edition : 37  


Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Prophylaxis of pulmonary embolism or venous thrombosis IV 500 1000 mL Injection given over 4 to 6 hours either during or immediately after surgery
2 hysteroscopy IV 50 100 mL Injection 32% solution of dextran 70 has been instilled into the uterus
3 Shock IV infusion 500 1000 mL Injection usual initial dose for rapid expansion of plasma volume is 500 to 1000 mL infused at a rate of 20 to 40 mL/minute. A hypertonic solution of 6% dextran 70 in sodium chloride 7.5% is also available for use as a plasma expander, given in a single intravenous dose of 250 mL over 2 to 5 minutes, followed by isotonic fluids as required.

Ref :-  Book : Martindale    Page : 1168   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1

Ref :- Book :    Page :    Edition :   
►  Side Effect : Hypersensitivity reactions, Fever, Nasal congestion, Joint pains, Urticaria, Hypotension, Bronchospasm, Nausea, Vomiting
Ref :-   Book : Martindale    Page : 1168   Edition : 37.  

►  Drug Interaction : Drug interaction of Dextran is with Heparin
Ref :-   Book : Martindale    Page : 1167   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  Anticoagulant effect of heparin may be enhanced by dextran
Ref :-   Book : Martindale    Page : 1167   Edition : 37.  


►  Contraindication : Heart failure, Renal failure, Renal impairment, Thrombocytopenia, Chronic liver disease, haemorrhage, Pulmonary oedema
Ref :-   Book : Martindale    Page : 1167   Edition : 37.  
  ►  Mechanism of Action :   Dextran 70 is a plasma volume expander. 6 % sulution of dextran 70 exerts a colloidal osmotic pressure simlar to that of plasma proteins and thus produces less expansion of plasma volume then dextrans of a lower molecular weight. Dextran 70 also reduces blood viscosity, interferes with fibrin polymerization, has an antiplatelet effect, and inhibits sludging or aggregation of red blood cells
Ref :-   Book : Martindale    Page : 1168   Edition : 37.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions

​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Fecal, Gastrointestinal tract, Renal
Ref :-   Book : Martindale    Page : 1168   Edition : 37.  

►    Plasma Half-life :   Min value :-   24 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1168   Edition : 37.  

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA