Dextran is a Medicine belongs to Plasma Expanders group whose information about Brand can be referenced from   Book : Martindale    Page : 1168   Edition : 37,

  ►   Brandname :
Gentran 70,RescueFlow,Hyskon,Macrodex


  ►  Strength :
Injection with 6  %,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1168   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration :
IV,
Reference :-   Book : Martindale    Page : 1168   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Prophylaxis of pulmonary embolism or venous thrombosis IV 500 1000 mL Injection given over 4 to 6 hours either during or immediately after surgery
2 hysteroscopy IV 50 100 mL Injection 32% solution of dextran 70 has been instilled into the uterus
3 Shock IV infusion 500 1000 mL Injection usual initial dose for rapid expansion of plasma volume is 500 to 1000 mL infused at a rate of 20 to 40 mL/minute. A hypertonic solution of 6% dextran 70 in sodium chloride 7.5% is also available for use as a plasma expander, given in a single intravenous dose of 250 mL over 2 to 5 minutes, followed by isotonic fluids as required.

Ref :-  Book : Martindale    Page : 1168   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect :
hypersensitivity reactions, fever, nasal congestion, joint pains, Urticaria, hypotension, bronchospasm, nausea, vomiting,
Ref :-   Book : Martindale    Page : 1168   Edition : 37,
►  Drug Interaction : Drug interaction of Dextran is with
Heparin ,
Ref :-   Book : Martindale    Page : 1167   Edition : 37,

  ►    Mechanism of Drug Drug Interaction : 
anticoagulant effect of heparin may be enhanced by dextran ,
Ref :-   Book : Martindale    Page : 1167   Edition : 37,

►  Contraindication :
heart failure, renal failure, renal impairment, thrombocytopenia, chronic liver disease, haemorrhage, Pulmonary oedema,
Ref :-   Book : Martindale    Page : 1167   Edition : 37,
  ►  Mechanism of Action :  
Dextran 70 is a plasma volume expander. 6 % sulution of dextran 70 exerts a colloidal osmotic pressure simlar to that of plasma proteins and thus produces less expansion of plasma volume then dextrans of a lower molecular weight. Dextran 70 also reduces blood viscosity, interferes with fibrin polymerization, has an antiplatelet effect, and inhibits sludging or aggregation of red blood cells ,
Ref :-   Book : Martindale    Page : 1168   Edition : 37,

Pathway of Dietry Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions

​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :  
Fecal, Gastrointestinal tract, Renal,
Ref :-   Book : Martindale    Page : 1168   Edition : 37,

►    Plasma Half-life :  
Min value :-   24 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1168   Edition : 37,

►    Peak Plasma Concentration :  
Min value :-   NA    Max value :-   NA