Dextromethorphan is a Medicine belongs to Antitussive group whose information about Brand can be referenced from   Book : Martindale    Page : 1696   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Alex,Lastuss,Lexcof,Adult Dry Cough,Benylin Dry Coughs Non-Drowsy,Aero Tuss 12,Buckleys Cough,Creo-Terpin,Expect-D

  ►  Strength : Lozenge with 5  mg, Lozenge with 7.5  mg, Tablet with 10  mg/5mL, Syrup with 30  mg/5mL, Syrup with 7.5  mg/5mL, Syrup with 15  mg/5mL, Syrup with 30   mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 563   Edition : 12, Basic & Clinical pharmacology    Page : 563   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1695   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Non-productive cough Oral 10 20 mg Dose: given every 4 hour, maximum of 120 mg in 24 hours.
2 Non-productive cough Oral 30 mg Dose: given every 6 to 8 hour, maximum of 120 mg in 24 hours.

Ref :-  Book : Martindale    Page : 1695   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Non-productive cough 4 Year 6 Year Oral 2.5 5 mg
2 Non-productive cough 4 Year 6 Year Oral 7.5 mg
3 Non-productive cough 6 Year 12 Year Oral 5 10 mg
4 Non-productive cough 6 Year 12 Year Oral 15 mg

Ref :- Book : Martindale    Page : 1695   Edition : 37,
►  Side Effect : Dizziness, gastrointestinal disturbance,
Ref :-   Book : Martindale    Page : 1695   Edition : 37,

►  Drug Interaction : Drug interaction of Dextromethorphan is with Monoamine Oxidase Inhibitor, Selective nonadrenaline reuptake inhibitors,  Amiodarone , Haloperidol , Propafenone, Thioridazine , Quinidine , Linezolid ,
Ref :-   Book : Martindale    Page : 1695   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Severe and sometimes fatal reactions have been reported after use of dextromethorphan in patients receiving MAOIs. Dextromethorphan is primarily metabolised by the cytochrome P450 isoenzyme CYP2D6; the possibility of interactions with inhibitors of this enzyme, including amiodarone, haloperidol, propafenone, quinidine, SSRIs, and thioridazine, should be borne in mind. Serotonin syndrome-like symptoms have occurred when dextromethorphan has been taken with linezolid.,
Ref :-   Book : Martindale    Page : 1694   Edition : 37,


►  Contraindication : respiratory failure, asthma, Care is advisable in patients with bronchitis, emphysema, or in other conditions where chronic or persistent cough occurs,
Ref :-   Book : Martindale    Page : 1695   Edition : 37,
  ►  Mechanism of Action :   it has a central action on the cough centre in the medulla. It is also an antagonist of N-methyl-D-aspartate (NMDA) receptors. ,
Ref :-   Book : Martindale    Page : 1695   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Bacopa monnieri i. e brahmi with same pathway,

  ►  Pathway with its reference as follows :-
  • NMDA receptor angagonist . --- (Aguiar, Sebastian. "Neuropharmacological Review Of The Nootropic Herb Bacopa Monnieri". 16 4 (2013): 313-326. Web. 21 Jan. 2017. )

  •   ►  URL -- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746283/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- GREEN TEA with green tea effect the metabolism of dextromethpphan .,

      ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1695   Edition : 37,


    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA