Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No	Ailment	Route	Dose Min	Dose Max	Unit	Dosage Form	Frequency	Additional Info
1		Oral				Oral solution		Sodium bicarbonate, sodium citrate, and potassium citrate cause alkalinisation of the urine. They may therefore be given to relieve discomfort in mild urinary- tract infections and to prevent the development of uric-acid renal calculi in the initial stages of uricosuric therapy for hyperuricaemia in chronic gout. In both cases, they are given with a liberal fluid intake, usually by mouth, in divided doses of up to about 10 g daily.
2		rectal				Enema		Sodium citrate 3% irrigation may be useful for the dissolution of blood clots in the bladder as an alternative to sodium chloride 0.9%. Enemas containing sodium citrate are given rectally as osmotic laxatives. Sodium citrate is also a common ingredient in cough mixtures
3	Eye burn	ophthalmic	10		%	Eye Drop

Adult Dose

S.No	Ailment	Route	Dose Min	Dose Max	Unit	Dosage Form	Frequency	Additional Info
1		Oral				Oral solution		Sodium bicarbonate, sodium citrate, and potassium citrate cause alkalinisation of the urine. They may therefore be given to relieve discomfort in mild urinary- tract infections and to prevent the development of uric-acid renal calculi in the initial stages of uricosuric therapy for hyperuricaemia in chronic gout. In both cases, they are given with a liberal fluid intake, usually by mouth, in divided doses of up to about 10 g daily.
2		rectal				Enema		Sodium citrate 3% irrigation may be useful for the dissolution of blood clots in the bladder as an alternative to sodium chloride 0.9%. Enemas containing sodium citrate are given rectally as osmotic laxatives. Sodium citrate is also a common ingredient in cough mixtures
3	Eye burn	ophthalmic	10		%	Eye Drop

Ref :-  Book : Martindale    Page : 1819   Edition : 37   Martindale    Page : 1820   Edition : 37  

Pediatric Dose

Ref :- Book :

►  Side Effect : Stomach cramps, Belching, Flatulence
Ref :-   Book : Martindale    Page : 1819   Edition : 37.  
►  Drug Interaction : Drug interaction of Di-sodium Hydrogen citrate is with NA

  ►    Mechanism of Drug Drug Interaction :  Citrate salts taken orally can enhance the absorption of aluminium from the gastrointestinal tract. Patients with impaired renal function are particularly susceptible to aluminium accumulation and citrate-containing oral preparations, including many effervescent or dispersible tablets, are best avoided by patients with renal failure taking aluminium-containing compounds.
Ref :-   Book : Martindale    Page : 1819   Edition : 37.  

►  Contraindication : Sodium-containing salts should be given extremely cautiously to patients with heart failure, oedema, renal impairment, hypertension, eclampsia, or aldosteronism
Ref :-   Book : Martindale    Page : 1819   Edition : 37.  

  ►  Mechanism of Action :   Bicarbonate-providing salts are alkalinising agents used for a variety of purposes including the correction of metabolic acidosis, alkalinisation of the urine, and as antacids
Ref :-   Book : Martindale    Page : 1819   Edition : 37.  

►   Route of Elimination :   Renal
Ref :-   Book : Martindale    Page : 1819   Edition : 37.  
►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA