Diamorphine Hydrochloride/Heroin Hydrochloride is a Medicine belongs to Opoid analgesic group whose information about Brand can be referenced from   Book : Martindale    Page : 46   Edition : 37,

  ►   Brandname : Diaphin

  ►  Strength : Injection with   , Linctus with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 46   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : SC, IV, IM, intranasal, IV infusion, Continuous subcutaneous infusion, Intraspinally,
Reference :-   Book : Martindale    Page : 45   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 acute pain s.c/ i.m 5 10 mg Injection Dose: Given every 4 hour
2 Pain in myocardial infarction slow i.v 5 mg Injection Dose: Given at a rate of 1 mg/minute with a further dose of 2.5 to 5 mg if required; doses may be reduced by one-half for elderly or frail patients.
3 Acute pulmonary oedema IV 2.5 5 mg Injection Dose: Given at a rate of 1 mg/minute with a further dose of 2.5 to 5 mg
4 Chronic pain s.c/ i.m 5 10 mg Injection Dose: Given every 4 hours; the dose may be increased according to needs.

Ref :-  Book : Martindale    Page : 45   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Acute or chronic pain continuous i.v infusion 2.5 7 micrograms/kg/hour Injection
2 Acute or chronic pain IV 50 micrograms/kg Injection
3 Acute or chronic pain 1 Month 12 Year continuous i.v infusion 12.5 25 micrograms/kg/hour Injection
4 Acute or chronic pain 1 Month 3 Month IV 20 mcg/kg Injection
5 Acute or chronic pain 3 Month 6 Month IV 25 50 micrograms/kg Injection
6 Acute or chronic pain 6 Month 12 Month IV 75 micrograms/kg Injection
7 Acute or chronic pain 1 Month 12 Year Oral 100 200 micrograms/kg
8 Acute pain in emergency setting or short painful procedures only Weighing over 10 kg intranasal 100 micrograms/kg Solution
9 Acute or chronic pain 1 Year 12 Year IV 75 100 micrograms/kg Injection

Ref :- Book : Martindale    Page : 45   Edition : 37,
►  Side Effect : nausea, vomiting, constipation, drowsiness, Confusion, dry mouth, Dizziness, sweating, facial flushing, headache, vertigo, bradycardia, tachycardia, palpitations, Orthostatic hypotension, hypothermia, Restlessness, changes in mood, decreased libido, decreased potency, hallucinations, Miosis, hypotension,
Ref :-   Book : Martindale    Page : 44,106   Edition : 37,

►  Drug Interaction : Drug interaction of Diamorphine Hydrochloride/Heroin Hydrochloride is with Alcohol, Anaesthetics, Hypnotics, Tricyclic antidepressants, Anxiolytics,  Cyclizine , Cimetidine , Cisapride , Metoclopramide , Domperidone ,
Ref :-   Book : Martindale    Page : 44,107   Edition : 37, Martindale    Page : 44.107   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The depressant effects of opioid analgesics are enhanced by other CNS depressants such as alcohol, anaesthetics, anxiolytics, hypnotics, tricyclic antidepressants, and antipsychotics. Cyclizine may counteract the haemodynamic benefits of opioids. Gastrointestinal effects may delay absorption of mexiletine or may be counteractive as with cisapride, metoclopramide, or domperidone. ,
Ref :-   Book : Martindale    Page : 44-107   Edition : 37,


►  Contraindication : Obstructive airway disease, Acute alcoholism, Conbulsive disorder, convulsive disorder, Head injury, adrenocortical insufficiency, hepatic impairment, renal impairment, prostatic hyperplasia, inflammatory or obstructive bowel disorders, Myasthenia gravis, conditions in which intracranial pressure is raised, Comatose patients, Avoided in patients at risk of paralytic ileus, Hypotension shock, Opioid analgesics should be given with great care to infants, especially neonates,
Ref :-   Book : Martindale    Page : 44,107   Edition : 37,
  ►  Mechanism of Action :   It is an opioid analgesic with agonist activity mainly at μ opioid receptors and perhaps at κ and δ receptors. It acts mainly on the CNS and smooth muscle.,
Ref :-   Book : Martindale    Page : 45-93   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Poppy seed with Another pathway, Poppy seed with Another pathway,

  ►  Pathway with its reference as follows :-
  • Poppy Seed having active constituent morphine which having pain-killing properties . --- (Madani, S., & T, S. (2014). A REVIEW ON PAPAVER SOMNIFERUM (OPIUM POPPY). International Standard Serial Number, 3(6), 2319-8141. )
  • Poppy Seed having active constituent morphine which having pain-killing properties . --- (Madani, S., & T, S. (2014). A REVIEW ON PAPAVER SOMNIFERUM (OPIUM POPPY). International Standard Serial Number, 3(6), 2319-8141. )
  • Poppy Seed having active constituent morphine which having pain-killing properties . --- (Madani, S., & T, S. (2014). A REVIEW ON PAPAVER SOMNIFERUM (OPIUM POPPY). International Standard Serial Number, 3(6), 2319-8141. )
  • Poppy Seed having active constituent morphine which having pain-killing properties . --- (Madani, S., & T, S. (2014). A REVIEW ON PAPAVER SOMNIFERUM (OPIUM POPPY). International Standard Serial Number, 3(6), 2319-8141. )

  •   ►  URL -- http://www.ijupbs.com/Uploads/30.%20RPA1415147015.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 45   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA