Diazoxide is a Medicine belongs to Antihypertensive Agents group whose information about Brand can be referenced from   Book : Martindale    Page : 1386   Edition : 37,

  ►   Brandname : Eudemine,Hyperstat,Proglycem

  ►  Strength : Injection with 15  mg/ml, Capsule with 50  mg, Suspension with 50  mg/ml, Tablet with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 189   Edition : 12, Martindale    Page : 1386   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 1385   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Hypoglycaemia Oral 3 5 mg/kg Dose: Given daily in 2 or 3 divided doses
2 Hypertensive crises IV bolus 1 3 mg/kg Injection Dose: Given with in 30 seconds, up to a maximum dose of 150 mg, and repeated after 5 to 15 minutes if required.

Ref :-  Book : Martindale    Page : 1385   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Hypoglycaemia Oral 5 mg/kg b.d.
2 Hypoglycaemia 1 month and above Oral 1.7 mg/kg t.i.d.
3 hypertension Oral 1.7 mg/kg t.i.d.
4 Hypertensive emergencies 1 month and over IV 1 3 mg/kg Injection
5 Hypoglycaemia IV 5 mg/kg Injection b.d.
6 Hypoglycaemia 1 month and above IV 1.7 mg/kg Injection t.i.d.
7 hypertension Oral 1.7 mg/kg t.i.d.

Ref :- Book : Martindale    Page : 1385-1386   Edition : 37,
Precaution :- If a Patient is using 'Diazoxide' drug in    disease, then Please causes conduction over accessory pathway in av blockade .

►  Side Effect : hypotension, Hyperglycaemia, Dysgeusia, nausea, anorexia, gastrointestinal disturbance, extrapyramidal symptoms, eosinophilia, thrombocytopenia, cardiac arrhythmia, tachycardia, palpitations, bradycardia, Confusion, convulsion, loss of consciousness, renal impairment, burning sensation in the injected vein, mild hyperuricaemia, marked ECG changes, neurological deficit, hypertrichosis, headache, Dizziness, tinnitus, Blurred Vision, angina,
Ref :-   Book : Martindale    Page : 1385   Edition : 37,

►  Drug Interaction : Drug interaction of Diazoxide is with Diuretic Agents ,  NA

  ►    Mechanism of Drug Drug Interaction :  The hyperglycaemic, hyperuricaemic, and hypotensive actions of diazoxide may be enhanced by diuretics. Use of diazoxide with other antihypertensives or vasodilators may lead to increased risk of hypotension,
Ref :-   Book : Martindale    Page : 1385   Edition : 37,


►  Contraindication : Pregnancy, renal impairment, used with care in patients with impaired cardiac or cerebral circulation and in patients with aortic coarctation, arteriovenous shunt, heart failure, or other cardiac disorders in which an increase in cardiac output could be detrimental,
Ref :-   Book : Martindale    Page : 1385   Edition : 37,
  ►  Mechanism of Action :   Diazoxide increases the concentration of glucose in the plasma; it inhibits the secretion of insulin by the beta cells of the pancreas, and may increase the hepatic output of glucose. ,
Ref :-   Book : Martindale    Page : 1385   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Garlic with Another pathway,

  ►  Pathway with its reference as follows :-
  • Allin & Allicin act as a vasodilator --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1385   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   24 hours,    Max value :-   NA
    Ref :-   Book : Basic & Clinical pharmacology    Page : 182   Edition : 12,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA