Dicyclomine Hcl/Dicyloverine Hcl is a Medicine belongs to Antimuscarinic Anticholinergic group whose information about Brand can be referenced from   Book : Martindale    Page : 1874   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Cyclominol,Cyclopam,Merbentyl,Antispas,Bentyl,Byclomine,Dibent,Or- Tyl,Cyclominol,Cyclopam,Dysmen,Meftal SPas,Normaxin,Normaxin RT

  ►  Strength : Capsule with 10  mg, Capsule with 20  mg, Tablet with 20  mg, Syrup with 10/5  mg/ml, Injection with 10  mg/ml, Oral solution with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 127   Edition : 12, Martindale    Page : 1874   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM,
Reference :-   Book : Martindale    Page : 1874   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Gastrointestinal spasm Oral 10 20 mg t.i.d.
2 Gastrointestinal spasm IM 20 mg Injection q.i.d. Dose: Given in patients in whom oral therapy is temporarily impractical, but should not be used for longer than 1 to 2 days.

Ref :-  Book : Martindale    Page : 1874   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Gastrointestinal smooth muscle spasm 6 Month 2Year Oral 5 10 mg t.i.d/q.i.d
2 Gastrointestinal smooth muscle spasm 2 Year 12 Year Oral 10 mg t.i.d.
3 Gastrointestinal spasm Over 12 Year Oral 10 20 mg t.i.d.
4 Gastrointestinal spasm Over 12 Year IM 20 mg Injection q.i.d.

Ref :- Book : Martindale    Page : 1874   Edition : 37,
►  Side Effect : Dryness of the mouth, thirst, reduced bronchial secretions, mydriasis, cycloplegia, photophobia, Flushing of the skin, dryness of the skin, tachycardia, palpitations, arrhythmia, difficulty in micturition, transient bradycardia, constipation,
Ref :-   Book : Martindale    Page : 1343, 1874   Edition : 37,

►  Drug Interaction : Drug interaction of Dicyclomine Hcl/Dicyloverine Hcl is with , Phenothiazine antipsychotics, Tricyclic antidepressant , Monoamine Oxidase Inhibitor,  Amantadine , Phenothiazine, , Cisapride , Domperidone , Metoclopramide ,
Ref :-   Book : Martindale    Page : 1343,1344   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The effects of Dicyclomine and other antimuscarinics may be enhanced by use with other drugs having antimuscarinic properties, such as amantadine, some antihistamines, phenothiazine antipsychotics, and tricyclic antidepressants. Inhibition of drug-metabolising enzymes by MAOIs may possibly enhance the effects of antimuscarinics. The reduction in gastric motility caused by antimuscarinics may affect the absorption of other drugs. Antimuscarinics may also antagonise the gastrointestinal effects of cisapride, domperidone, and metoclopramide. Antimuscarinics and parasympathomimetics may counteract each others effects. ,
Ref :-   Book : Martindale    Page : 1343-1344   Edition : 37,


►  Contraindication : Age less than 6 months, Breast feeding, Gastrointestinal obstruction, Glaucoma, Myasthenia gravis, obstructive uropathy, Reflux esophagitis, Severe ulcerative colitis , Toxic megacolon,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 819   Edition : 3,
  ►  Mechanism of Action :   It decreases acid secretion by inhibiting acetylcholine binding to muscarinic Ach receptors on parietal cells. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 819   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Peppermint oil with Another pathway, Peppermint oil with Another pathway,

  ►  Pathway with its reference as follows :-
  • antispasmodic and Anticholinergic --- ( Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • menthol have antispasmodic effect --- ( Meamarbashi, A. & Rajabi, A. (2013). The effects of peppermint on exercise performance. J Int Soc Sports Nutr, 10(1), 15. http://dx.doi.org/10.1186/1550-2783-10-15 )
  • antispasmodic and Anticholinergic --- ( Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • menthol have antispasmodic effect --- ( Meamarbashi, A. & Rajabi, A. (2013). The effects of peppermint on exercise performance. J Int Soc Sports Nutr, 10(1), 15. http://dx.doi.org/10.1186/1550-2783-10-15 )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607906/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Faecal,
    Ref :-   Book : Martindale    Page : 1834   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   1.8 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1834   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   1.5 hours,
    Ref :-   Book : Martindale    Page : 1834   Edition : 38,