Didanosine is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 962   Edition : 37, Martindale    Page : 960   Edition : 37,

  ►   Brandname : Dinex,Videx

  ►  Strength : Oral solution with   , Capsule (Enteric coated) with   , Tablet (Enteric Coated) with   , Buffered chewable/dispersible tablets with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 962   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 962   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 HIV infection and AIDS Oral 400 mg Buffered chewable/dispersible tablets Dose: For: weighing more than 60 kg, Dose: given daily, dose should be taken atleast 30 minutes before, or 2 hours after, a meal.
2 HIV infection and AIDS Oral 250 mg Buffered chewable/dispersible tablets Dose: For: weighing under 60 kg, Dose: given daily, dose should be taken atleast 30 minutes before, or 2 hours after, a meal.
3 HIV infection and AIDS Oral 200 mg Capsule (Enteric coated) Dose: Given a single daily dose, those weighing less than 25 kg, dose should be taken atleast 30 minutes before, or 2 hours after, a meal.
4 HIV infection and AIDS Oral 400 mg Capsule (Enteric coated) Dose: For: weighing more than 60 kg, Dose: given daily, dose should be taken atleast 30 minutes before, or 2 hours after, a meal.
5 HIV infection and AIDS Oral 250 mg Capsule (Enteric coated) Dose: For: weighing under 60 kg, Dose: given daily, dose should be taken atleast 30 minutes before, or 2 hours after, a meal.

Ref :-  Book : Martindale    Page : 962   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 HIV infection 2 Week 8 Month Oral 100 mg/m2 Oral solution or enteric-coated tablet b.d.
2 HIV infection Over 8 months Oral 120 mg/m2 Oral solution or enteric-coated tablet b.d.
3 HIV infection 20 to less than 25 kg Oral 200 mg enteric coated capsules o.d.
4 HIV infection 25 to less than 60 kg Oral 250 mg enteric coated capsules o.d.
5 HIV infection 60 kg or more Oral 400 mg enteric coated capsules o.d.
6 HIV infection children older than 3 months of age Oral 240 mg/m2 Buffered chewable/dispersible tablets
7 HIV infection children older than 6 years Oral 240 mg/m2 Capsule (Enteric coated)
8 HIV infection children older than 6 years Oral 180 mg/m2 Capsule (Enteric coated)
9 HIV infection children older than 3 months of age Oral 180 mg/m2 Buffered chewable/dispersible tablets

Ref :- Book : Martindale    Page : 962    Edition : 37,
►  Side Effect : diarrhea, abdominal pain, peripheral neuropathy, fatigue, headache, nausea, Rashes, vomiting, abnormal liver fuction tests, alopecia, amnesia, asthenia, dry mouth, fever, Flatulence, parotid gland enlargement, leucopenia, hypersensitivity reactions, anaphylaxis, hyperuricaemia, thrombocytopenia, Lactic acidosis, Immune reconstitution syndrome, lipodystrophy, central obesity, dorsocervical fat enlargement , peripheral wasting, facial wasting, breast enlargement, cushingoid appearance, hypertriglyceridaemia, hypercholesterolaemia, insulin resistance, Hyperglycaemia, Non cirrhotic portal hypertension, abnormal behaviour, Retinal and optic-nerve changes, anaemia, convulsion, hyperlipasaemia, hypertonia, rhabdomyolysis, Hyperlactataemia, Elevated creatine phosphokinase, myalgia, myositis,
Ref :-   Book : Martindale    Page : 960   Edition : 37,

►  Drug Interaction : Drug interaction of Didanosine is with xanthine/ bronchodilator , Antacid , HIV- protease inhibitors, FLUOROQUINOLONES , Antibacterials , ,  Pentamidine , Metronidazole , Vincristine, Allopurinol , Pentamidine , Metronidazole , Isoniazid , Vincristine, Methadone , Ganciclovir , Valganciclovir , Ketoconazole , Dapsone , Tenofovir , Lamivudine, Itraconazole ,
Ref :-   Book : Martindale    Page : 961   Edition : 37, Martindale    Page : 960.3   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Use of didanosine with other drugs known to cause pancreatitis (for example intravenous pentamidine) or with drugs that may cause peripheral neuropathy (for example metronidazole, isoniazid, and vincristine) should be avoided. An increase in the area under the plasma concentration- time curve for didanosine has been reported when allopurinol or other xanthine oxidase inhibitors are given concurrently; because of the risk of toxicity, use of didanosine with allopurinol is not recommended. Plasma concentrations of didanosine may be reduced by methadone and increased by ganciclovir or valganciclovir, although the degree may vary with specific didanosine preprations. Didanosine formulations (chewable or dispersible preparation) contain an antacid and other drugs that could be affected by an increased gastric pH (for example HIV-protease inhibitors, ketoconazole, Itraconazole and fluoroquinolone antibacterials, and dapsone) should be given at least 2 hours before didanosine. Didanosine preparations containing magnesium or aluminium antacids should not be given with tetracyclines. Use of didanosine with tenofovir results in increased plasma concentrations of didanosine and consequently an increased risk of didanosine-related adverse effects such as peripheral neuropathy, pancreatitis, and lactic acidosis. Fatalities have been reported. There have also been reports of virological failure and emergence of resistance at an early stage of treatment when didanosine and tenofovir were given with lamivudine as part of a once daily triple nucleoside regimen.,
Ref :-   Book : Martindale    Page : 961   Edition : 37,


►  Contraindication : used with extreme caution in patients with a history of pancreatitis and those with increased triglyceride concentrations and peripheral neuropathy, Patients co-infected with chronic hepatitis B or C and treated with combination antiretroviral therapy are at increased risk for severe and potentially fatal hepatic adverse events, didanosine may be associated with lactic acidosis, Dosage reduction may be necessary in renal impairment , Portal hypertension,
Ref :-   Book : Martindale    Page : 961   Edition : 37,
  ►  Mechanism of Action :   Didanosine is converted intracellularly to its active form dideoxyadenosine triphosphate. This triphosphate halts the DNA synthesis of retroviruses, including HIV, through competitive inhibition of reverse transcriptase and incorporation into viral DNA.,
Ref :-   Book : Martindale    Page : 960   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Castarospermum austrate i.e. Mareton bay Chestnut with Another pathway,

  ►  Pathway with its reference as follows :-
  • Castarospermine have Anti HIV activity. --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- VITAMIN B2 with Didanosine can inhibit crucial DNA-related riboflavin activity , which may be normalized by riboflavin supplementation ., L-CARNITINE with Severe peripheral neuropathy ofen develops in people taking didanosine or othe drug in its class . The people having neuropathy due to this drug were found to be deficient in acetyl-L- Carnitine .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf, http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 962   Edition : 37,


    ►    Plasma Half-life :   Min value :-   1.5 hour,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 962   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   1 hour,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 962   Edition : 37,