Diethylcarbamazine is a Medicine belongs to Antihelminthic Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 151   Edition : 37, Martindale    Page : 151   Edition : 37,

  ►   Brandname : Banocide,Hetrazan,Notezine

  ►  Strength : Tablet with 50  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 946   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 946   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Lymphatic filariasis Oral 1 mg/kg Tablet Dose: Gradually increased over 2 to 3 days to 6 mg/kg daily for 12 days.
2 Loiasis Oral 6 9 mg/kg Tablet Dose: Given daily in 3 divided doses for 12 to 21 days. In heavy infections rapid killing of microfilariae can cause severe adverse effects including encephalitis and treatment should start with very small doses, increasing gradually over 4 days.
3 Toxocariasis Oral 6 mg/kg Tablet Dose: Given daily in 2 divided doses for 21 days may be given.
4 Prophylaxis of loiasis Oral 300 mg Tablet Dose: Given weekly is recommended by WHO
5 Toxocariasis Oral 1 mg/kg Tablet b.d. Dose: Gradually increase to 3 mg/kg twice daily, WHO recommended dose to reduce the intensity of reactions

Ref :-  Book : Martindale    Page : 151   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Lymphatic filariasis children under 10 year Oral 36 mg/kg Tablet
2 Loiasis Oral 9 mg/kg Tablet
3 Toxocariasis Oral 6 mg/kg Tablet
4 Toxocariasis Oral 1 mg/kg Tablet b.d.

Ref :- Book : Martindale    Page : 151   Edition : 37,
►  Side Effect : anorexia, nausea, headache, Dizziness, drowsiness, vomiting, hypersensitivity reactions, death, ocular toxicity,
Ref :-   Book : Martindale    Page : 150   Edition : 37,

►  Drug Interaction : Drug interaction of Diethylcarbamazine is with NA

  ►    Mechanism of Drug Drug Interaction :  ,
Ref :-   Book :    Page :    Edition : ,


►  Contraindication : heart failure, Hypersensitivity, renal failure, encephalopathy, Infants, pregnant women, the elderly, and the debilitated, especially those with cardiac or renal disease,
Ref :-   Book : Martindale    Page : 150   Edition : 37,
  ►  Mechanism of Action :   The mechanism of action of Diethylcarbamazine against susceptible filarial species is not well understood, but the drug appears to exert a direct effect on W. bancrofti microfilariae by causing organelle damage and apoptosis. The mechanism of filaricidal action of Diethylcarbamazine against adult worms is unknown. Some studies suggest that it compromises intracellular processing and transport of certain macromolecules to the plasma membrane.,
Ref :-   Book : Goodman    Page : 1453   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Sangu pushpam with Another pathway, Anogeissus leiocarpus with Another pathwayAnother pathway, Anogeissus leiocarpus with Another pathwayAnother pathway, k senegalensis with Another pathway, Khaya senegalensis with Another pathway, Euphorbia hirta with Another pathway, Parquetina nigrescens with Another pathway, Discoglypremna caloneura with Another pathway, Polyalthia suaveolens with Another pathway,

  ►  Pathway with its reference as follows :-
  • Anti filarial effect . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Beneficial in Filariasis Treatment --- (Ndjonka, Dieudonne. "Natural Products As A Source For Treating Neglected Parasitic Diseases". Int J Of Molecular Science 14.2 (2013): 3395–3439. Web. 2 Feb. 2017. )
  • Beneficial in Filariasis Treatment --- ( Ndjonka, Dieudonne. "Natural Products As A Source For Treating Neglected Parasitic Diseases". Int J Of Molecular Science 14.2 (2013): 3395–3439. Web. 2 Feb. 2017. )
  • Beneficial in Filariasis Treatment --- (Ndjonka, Dieudonne. "Natural Products As A Source For Treating Neglected Parasitic Diseases". Int J Of Molecular Science 14.2 (2013): 3395–3439. Web. 2 Feb. 2017. )
  • Beneficial in Filariasis Treatment --- ( Ndjonka, Dieudonne. "Natural Products As A Source For Treating Neglected Parasitic Diseases". Int J Of Molecular Science 14.2 (2013): 3395–3439. Web. 2 Feb. 2017. )
  • Beneficial in Filariasis Treatment --- (Ndjonka, Dieudonne. "Natural Products As A Source For Treating Neglected Parasitic Diseases". Int J Of Molecular Science 14.2 (2013): 3395–3439. Web. 2 Feb. 2017. )
  • Beneficial in Filariasis Treatment --- (Ndjonka, Dieudonne. "Natural Products As A Source For Treating Neglected Parasitic Diseases". Int J Of Molecular Science 14.2 (2013): 3395–3439. Web. 2 Feb. 2017. )
  • Beneficial in Filariasis Treatment --- (Ndjonka, Dieudonne. "Natural Products As A Source For Treating Neglected Parasitic Diseases". Int J Of Molecular Science 14.2 (2013): 3395–3439. Web. 2 Feb. 2017. )
  • Beneficial in Filariasis Treatment --- (Ndjonka, Dieudonne. "Natural Products As A Source For Treating Neglected Parasitic Diseases". Int J Of Molecular Science 14.2 (2013): 3395–3439. Web. 2 Feb. 2017. )
  • Beneficial in Filariasis Treatment --- (Ndjonka, Dieudonne. "Natural Products As A Source For Treating Neglected Parasitic Diseases". Int J Of Molecular Science 14.2 (2013): 3395–3439. Web. 2 Feb. 2017. )
  • Beneficial in Filariasis Treatment --- (Ndjonka, Dieudonne. "Natural Products As A Source For Treating Neglected Parasitic Diseases". Int J Of Molecular Science 14.2 (2013): 3395–3439. Web. 2 Feb. 2017. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588050/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Goodman    Page : 1453   Edition : 12,


    ►    Plasma Half-life :
      Min value :-   2 hours,    Max value :-   10 hours,
    Ref :-   Book : Goodman    Page : 1453   Edition : 12,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours,
    Ref :-   Book : Goodman    Page : 1453   Edition : 12,